PMID- 36857915
OWN - NLM
STAT- MEDLINE
DCOM- 20230320
LR  - 20230320
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 253
DP  - 2023 Mar 15
TI  - Association between polyfluoroalkyl substances exposure and sex steroids in 
      adolescents: The mediating role of serum albumin.
PG  - 114687
LID - S0147-6513(23)00191-4 [pii]
LID - 10.1016/j.ecoenv.2023.114687 [doi]
AB  - BACKGROUND: Polyfluoroalkyl substances (PFASs) are an emerging class of 
      contaminants with endocrine disrupting hazards. The impact of PFASs exposure on 
      sex steroids remain inconclusive. METHODS: This study used data from the 
      2013-2016 National Health and Nutrition Examination Survey (NHANES), including 
      525 adolescents aged 12-19. We explored the association between serum PFASs and 
      sex steroids using multiple linear regression, weighted quantified sum (WQS) 
      regression, and Bayesian kernel machine regression (BKMR). Mediation analyses 
      were performed to assess whether serum albumin mediates the effects of PFASs on 
      sex steroids. RESULTS: Single exposure to perfluorohexane sulfonic acid (PFHxS) 
      or n-perfluorooctanoic acid (n-PFOA) was found to be inversely associated with 
      sex hormone binding protein (SHBG) after adjustment for confounders. Results from 
      both the WQS and BKMR models showed that mixed exposure to the five PFASs was 
      negatively associated with SHBG and testosterone (TT) in all adolescents, while 
      only in the WQS model, the mixed exposure to PFASs was negatively correlated with 
      E(2) and FAI in boys and negatively correlated with TT and SHBG in girls. Serum 
      albumin was found to possibly mediate 9.7 % of the association between mixed PFAS 
      exposure and TT, and 9.7 % of the association between mixed PFAS exposure and 
      SHBG. CONCLUSION: Our study demonstrates a negative association between mixed 
      exposure to PFASs and adolescent TT and SHBG levels, and suggests that albumin 
      may merit further study as a potential target for PFAS harm reduction.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Guo, Jianhui
AU  - Guo J
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou 350122, China.
FAU - Huang, Shuna
AU  - Huang S
AD  - Department of Clinical Research and Translation Center, The First Affiliated 
      Hospital of Fujian Medical University, Fuzhou 350001, China.
FAU - Yang, Le
AU  - Yang L
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou 350122, China.
FAU - Zhou, Jungu
AU  - Zhou J
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou 350122, China.
FAU - Xu, Xingyan
AU  - Xu X
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou 350122, China.
FAU - Lin, Shaowei
AU  - Lin S
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou 350122, China.
FAU - Li, Huangyuan
AU  - Li H
AD  - Department of Preventive Medicine, School of Public Health, Fujian Medical 
      University, Fuzhou 350122, China.
FAU - Xie, Xiaoxu
AU  - Xie X
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou 350122, China. Electronic address: 
      xiexiaoxu@aliyun.com.
FAU - Wu, Siying
AU  - Wu S
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Fujian 
      Medical University, Fuzhou 350122, China. Electronic address: fmuwsy@163.com.
LA  - eng
PT  - Journal Article
DEP - 20230227
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Serum Albumin)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 3XMK78S47O (Testosterone)
RN  - 0 (Fluorocarbons)
RN  - 0 (Alkanesulfonic Acids)
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - Adolescent
MH  - Nutrition Surveys
MH  - Serum Albumin
MH  - Bayes Theorem
MH  - *Environmental Pollutants
MH  - Gonadal Steroid Hormones
MH  - Testosterone
MH  - *Fluorocarbons/toxicity
MH  - *Alkanesulfonic Acids
OTO - NOTNLM
OT  - Adolescent
OT  - Mediation
OT  - Perfluoroalkyl substances
OT  - Serum albumin
OT  - Sex steroids
COIS- Declaration of Competing Interest The authors declare that they have no competing 
      interests. We would like to thank National Health and Nutrition Examination 
      Survey for providing the data. In the graph abstract, the structure of serum 
      albumin is derived from the results of Sugio et al. (Sugio et al., 1999) and the 
      structures of PFASs are derived from PubChem (https://pubchem.ncbi.nlm.nih.gov/).
EDAT- 2023/03/02 06:00
MHDA- 2023/03/21 06:00
CRDT- 2023/03/01 18:11
PHST- 2022/10/31 00:00 [received]
PHST- 2023/02/21 00:00 [revised]
PHST- 2023/02/23 00:00 [accepted]
PHST- 2023/03/02 06:00 [pubmed]
PHST- 2023/03/21 06:00 [medline]
PHST- 2023/03/01 18:11 [entrez]
AID - S0147-6513(23)00191-4 [pii]
AID - 10.1016/j.ecoenv.2023.114687 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2023 Mar 15;253:114687. doi: 
      10.1016/j.ecoenv.2023.114687. Epub 2023 Feb 27.