PMID- 36858404
OWN - NLM
STAT- MEDLINE
DCOM- 20230303
LR  - 20230303
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 36
IP  - 1
DP  - 2023 Dec
TI  - Clinical outcomes of pulmonary hypertension in pregnancy among women with 
      congenital heart disease in China.
PG  - 2183349
LID - 10.1080/14767058.2023.2183349 [doi]
AB  - OBJECTIVE: Pulmonary arterial hypertension (PAH) increases the risk for perinatal 
      women and newborns, especially in women with congenital heart disease (CHD). We 
      explored the maternal, perinatal, and postneonatal outcomes of PAH in pregnant 
      women with CHD in China. METHODS: A total of 95 pregnant women with CHD-PAH in 
      Beijing Anzhen Hospital from 2009 to 2013 were included retrospectively. We 
      described their characteristics and examined the associations between the grade 
      of PAH and maternal, perinatal, and postneonatal outcomes. RESULTS: The New York 
      Heart Association (NYHA) classification grade, delivery mode, and infant outcomes 
      in CHD-PAH patients were analyzed. Overall 95 patients with CHD-PAH, there were 
      17 patients in mild group(17.7%), 27 patients in moderate group (28.1%), and 51 
      patients in severe group (53.1%)。The CHD patients with mild PAH, were mostly NYHA 
      class I-II and CHD patients with severe PAH were NYHA class II-IVs. Cesarean 
      section (67.7%) was the most common method of delivery. The rate of therapeutic 
      abortion in the severe group (76.9%) was obviously higher than that in other 
      groups (11.5% in mild group and moderate group respectively), whereas there was 
      no term delivery in severe group, with 2 cases in mild group and moderated group 
      respectively . The rates of heart failure and therapeutic abortion in pregnant 
      women were positively associated with the severity of PAH. The rate of term 
      delivery was higher in patients whose CHD had been corrected by cardiac surgery 
      (83.3%) before pregnancy. CONCLUSION: Patients with severe PAH have poor cardiac 
      adaptability, poor maternal and fetal outcomes, and are contraindicated during 
      pregnancy. Patients with mild PAH are not absolutely contraindicated during 
      pregnancy, but their heart burden increases significantly in the third trimester. 
      Patients in mid-gestation should preferentially be delivered by cesarean section. 
      When pregnant patients prefer to continue pregnancy, their close monitoring is 
      essential. We provide useful data for guiding management of pregnancy and 
      delivery in patients with CHD in China.
FAU - Piao, Chunmei
AU  - Piao C
AD  - Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, P.R. China.
AD  - The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of 
      Education, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, 
      P.R. China.
FAU - Wang, Wen-Jing
AU  - Wang WJ
AD  - Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, P.R. China.
AD  - Department of Obstetrics and Gynecology, Beijing Ditan Hospital, Capital Medical 
      University, Beijing, P.R. China.
FAU - Deng, Yue
AU  - Deng Y
AD  - Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, P.R. China.
FAU - Wang, Kefang
AU  - Wang K
AD  - Department of Obstetrics and Gynecology, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing, P.R. China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - Infant, Newborn
MH  - Pregnancy
MH  - Infant
MH  - Female
MH  - Humans
MH  - *Hypertension, Pulmonary
MH  - Cesarean Section
MH  - Retrospective Studies
MH  - *Heart Defects, Congenital
MH  - China
OTO - NOTNLM
OT  - China
OT  - Pregnancy
OT  - congenital heart disease
OT  - pulmonary hypertension
EDAT- 2023/03/02 06:00
MHDA- 2023/03/04 06:00
CRDT- 2023/03/01 20:24
PHST- 2023/03/01 20:24 [entrez]
PHST- 2023/03/02 06:00 [pubmed]
PHST- 2023/03/04 06:00 [medline]
AID - 10.1080/14767058.2023.2183349 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2023 Dec;36(1):2183349. doi: 
      10.1080/14767058.2023.2183349.