PMID- 36858572
OWN - NLM
STAT- MEDLINE
DCOM- 20230303
LR  - 20230303
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 46
IP  - 3
DP  - 2023
TI  - Lipopolysaccharide Priming Exacerbates Anaphylatoxin C5a-Induced Anaphylaxis in 
      Mice.
PG  - 432-439
LID - 10.1248/bpb.b22-00766 [doi]
AB  - Anaphylaxis is a serious allergic or hypersensitivity reaction with a sudden 
      onset that can be life-threatening or fatal. Previous studies have highlighted 
      two pathways of anaphylaxis in mice. One is the classical immunoglobulin E 
      (IgE)-mediated pathway that involves mast cells and histamine. The other is an 
      alternative IgG-mediated pathway that involves basophils, monocytes/macrophages, 
      neutrophils, and the platelet-activating factor (PAF). However, little is known 
      about the mechanism by which complement anaphylatoxins contribute to the 
      induction of anaphylaxis. Infection is a cofactor that potentially amplifies the 
      risk of anaphylaxis. Here, we showed that priming with a lipopolysaccharide 
      (LPS), which mimics bacterial infection, exacerbates anaphylatoxin C5a-induced 
      anaphylaxis in mice. LPS plus C5a-induced anaphylaxis was mediated by histamine 
      and lipid mediators, especially PAF. Cell depletion experiments demonstrated that 
      LPS plus C5a-induced anaphylaxis depended on monocytes/macrophages, basophils, 
      and neutrophils. These results suggest that C5a is a potent inducer of 
      anaphylaxis in bacterial infections. Remarkably, the molecular and cellular 
      mediators of LPS plus C5a-induced anaphylaxis are mostly shared with IgE- and 
      IgG-mediated anaphylaxis. Therefore, combined inhibition of histamine and PAF may 
      be beneficial as a second-line treatment for severe anaphylaxis.
FAU - Yasuda, Makoto
AU  - Yasuda M
AD  - Division of Dento-oral Anesthesiology, Tohoku University Graduate School of 
      Dentistry.
FAU - Tanaka, Yukinori
AU  - Tanaka Y
AD  - Division of Dento-oral Anesthesiology, Tohoku University Graduate School of 
      Dentistry.
FAU - Bando, Kanan
AU  - Bando K
AD  - Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate 
      School of Dentistry.
FAU - Sugawara, Shunji
AU  - Sugawara S
AD  - Division of Oral Immunology, Tohoku University Graduate School of Dentistry.
FAU - Mizuta, Kentaro
AU  - Mizuta K
AD  - Division of Dento-oral Anesthesiology, Tohoku University Graduate School of 
      Dentistry.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Lipopolysaccharides)
RN  - 820484N8I3 (Histamine)
RN  - 0 (Anaphylatoxins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Anaphylaxis
MH  - Lipopolysaccharides
MH  - Histamine
MH  - Anaphylatoxins
MH  - Immunoglobulin E
MH  - Immunoglobulin G
OTO - NOTNLM
OT  - anaphylatoxin C5a
OT  - anaphylaxis
OT  - histamine
OT  - lipid mediator
OT  - lipopolysaccharide priming
OT  - mouse model
EDAT- 2023/03/02 06:00
MHDA- 2023/03/04 06:00
CRDT- 2023/03/01 20:53
PHST- 2023/03/01 20:53 [entrez]
PHST- 2023/03/02 06:00 [pubmed]
PHST- 2023/03/04 06:00 [medline]
AID - 10.1248/bpb.b22-00766 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2023;46(3):432-439. doi: 10.1248/bpb.b22-00766.