PMID- 36859633
OWN - NLM
STAT- MEDLINE
DCOM- 20230414
LR  - 20230724
IS  - 1540-8175 (Electronic)
IS  - 0742-2822 (Linking)
VI  - 40
IP  - 4
DP  - 2023 Apr
TI  - Prognostic impact of left ventricular systolic dysfunction in patients with mixed 
      aortic valve disease undergoing aortic valve replacement.
PG  - 318-326
LID - 10.1111/echo.15544 [doi]
AB  - BACKGROUND: The implications of left ventricular remodeling and dysfunction 
      before and after aortic valve replacement (AVR) for mixed aortic valve disease 
      (MAVD) are not well understood. This study aims to evaluate the impact of AVR on 
      left ventricular (LV) systolic function in MAVD, and determine the prognostic 
      value of postoperative LV global longitudinal strain (LV-GLS) and LV ejection 
      fraction (LVEF). METHODS: We retrospectively assessed 489 consecutive patients 
      with MAVD (defined as at least moderate aortic stenosis and at least moderate 
      aortic regurgitation) and baseline LVEF >/=50%, who underwent AVR between February 
      2003 and August 2018. All patients had baseline echocardiography, whereas 192 
      patients underwent postoperative echocardiography between 3 and 18 months after 
      AVR. The primary endpoint was all-cause mortality. RESULTS: Mean age was 65 +/- 15 
      years, and 65% were male. AVR in MAVD patients has a neutral effect on LV 
      systolic function quantitated by LVEF and LV-GLS. During a median follow-up 
      period of 5.8 years, 65 patients (34%) of 192 patients with follow-up 
      echocardiography died. The patients with postoperative LVEF >/=50% had better 
      survival than those with postoperative LVEF <50% (P < .001). Furthermore, among 
      patients with postoperative LVEF >/=50%, mortality differed between patients with 
      postoperative LV-GLS worse than -15% and those with postoperative LV-GLS better 
      than -15% (P < .001). CONCLUSIONS: In patients with MAVD who underwent AVR, the 
      mean postoperative LV-GLS and LVEF remain at a similar value to baseline. 
      However, worse postoperative LV-GLS and LVEF were both independently associated 
      with higher mortality in this population.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Saijo, Yoshihito
AU  - Saijo Y
AD  - Department of Cardiovascular Medicine, Heart, Thoracic and Vascular Institute, 
      Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Wang, Tom Kai Ming
AU  - Wang TKM
AUID- ORCID: 0000-0001-5570-9402
AD  - Department of Cardiovascular Medicine, Heart, Thoracic and Vascular Institute, 
      Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Isaza, Nicolas
AU  - Isaza N
AD  - Department of Cardiovascular Medicine, Heart, Thoracic and Vascular Institute, 
      Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Conic, Julijana Z
AU  - Conic JZ
AD  - Department of Cardiovascular Medicine, Heart, Thoracic and Vascular Institute, 
      Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Johnston, Douglas
AU  - Johnston D
AD  - Department of Thoracic and Cardiovascular Surgery, Heart, Thoracic and Vascular 
      Institute, Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Roselli, Eric E
AU  - Roselli EE
AD  - Department of Thoracic and Cardiovascular Surgery, Heart, Thoracic and Vascular 
      Institute, Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Desai, Milind Y
AU  - Desai MY
AD  - Department of Cardiovascular Medicine, Heart, Thoracic and Vascular Institute, 
      Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Grimm, Richard A
AU  - Grimm RA
AD  - Department of Cardiovascular Medicine, Heart, Thoracic and Vascular Institute, 
      Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Svensson, Lars G
AU  - Svensson LG
AD  - Department of Thoracic and Cardiovascular Surgery, Heart, Thoracic and Vascular 
      Institute, Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Kapadia, Samir R
AU  - Kapadia SR
AD  - Department of Cardiovascular Medicine, Heart, Thoracic and Vascular Institute, 
      Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Griffin, Brian P
AU  - Griffin BP
AD  - Department of Cardiovascular Medicine, Heart, Thoracic and Vascular Institute, 
      Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Popovic, Zoran B
AU  - Popovic ZB
AUID- ORCID: 0000-0001-5692-2299
AD  - Department of Cardiovascular Medicine, Heart, Thoracic and Vascular Institute, 
      Cleveland Clinic, Cleveland, Ohio, USA.
LA  - eng
PT  - Journal Article
DEP - 20230301
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
SB  - IM
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Aortic Valve/diagnostic imaging/surgery
MH  - Prognosis
MH  - Retrospective Studies
MH  - *Aortic Valve Stenosis/complications/diagnostic imaging/surgery
MH  - *Ventricular Dysfunction, Left/complications/diagnostic imaging
MH  - Ventricular Function, Left
MH  - Stroke Volume
MH  - *Heart Valve Prosthesis Implantation
OTO - NOTNLM
OT  - aortic valve replacement
OT  - mixed aortic valve disease
OT  - speckle tracking
OT  - strain
EDAT- 2023/03/02 06:00
MHDA- 2023/04/14 06:42
CRDT- 2023/03/01 23:55
PHST- 2023/01/19 00:00 [revised]
PHST- 2022/05/09 00:00 [received]
PHST- 2023/02/06 00:00 [accepted]
PHST- 2023/04/14 06:42 [medline]
PHST- 2023/03/02 06:00 [pubmed]
PHST- 2023/03/01 23:55 [entrez]
AID - 10.1111/echo.15544 [doi]
PST - ppublish
SO  - Echocardiography. 2023 Apr;40(4):318-326. doi: 10.1111/echo.15544. Epub 2023 Mar 
      1.