PMID- 36860729
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230303
IS  - 2514-2119 (Electronic)
IS  - 2514-2119 (Linking)
VI  - 7
IP  - 2
DP  - 2023 Feb
TI  - Cardiac light-chain deposition disease and hints at diagnosing: a case report.
PG  - ytad049
LID - 10.1093/ehjcr/ytad049 [doi]
LID - ytad049
AB  - BACKGROUND: Light-chain deposition disease (LCDD) is a systemic disorder 
      characterized by non-amyloidotic light-chain deposition in various organs with 
      Bence-Jones type monoclonal gammopathy. Although known as monoclonal gammopathy 
      of renal significance, it may involve interstitial tissue of various organs, and 
      in rare cases, proceeds to organ failure. We present a case of cardiac LCDD in a 
      patient initially suspected of dialysis-associated cardiomyopathy. CASE SUMMARY: 
      A 65-year-old man with end-stage renal disease requiring haemodialysis presented 
      with fatigue, anorexia, and shortness of breath. He had a history of recurrent 
      congestive heart failure and Bence-Jones type monoclonal gammopathy. A cardiac 
      biopsy performed for suspected light-chain cardiac amyloidosis was negative for 
      diagnostic Congo-red stain, however, paraffin immunofluorescence examination for 
      light-chain suggested diagnosis of cardiac LCDD. DISCUSSION: Cardiac LCDD may go 
      undetected leading to heart failure due to lack of clinical awareness and 
      insufficient pathological investigation. In heart failure cases with Bence-Jones 
      type monoclonal gammopathy, clinicians should consider not only amyloidosis but 
      also interstitial light-chain deposition. In addition, in patients with chronic 
      kidney disease of unknown cause, investigation is recommended to rule out cardiac 
      light-chain deposition disease concomitant with renal LCDD. Although LCDD is 
      relatively rare it occasionally affects multiple organs; therefore, it would be 
      better to describe it as a monoclonal gammopathy of clinical significance rather 
      than one of renal significance.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      European Society of Cardiology.
FAU - Nishioka, Ryo
AU  - Nishioka R
AUID- ORCID: 0000-0001-8654-7311
AD  - Department of Rheumatology, Kanazawa University Hospital, 13-1, Takara-machi, 
      Kanazawa, Ishikawa 920-8641, Japan.
FAU - Yoshida, Shohei
AU  - Yoshida S
AD  - Department of Cardiology, Kanazawa University Hospital, 13-1, Takara-machi, 
      Kanazawa, Ishikawa 920-8641, Japan.
FAU - Takamatsu, Hiroyuki
AU  - Takamatsu H
AD  - Department of Haematology, Kanazawa University Hospital, 13-1, Takara-machi, 
      Kanazawa, Ishikawa 920-8641, Japan.
FAU - Kawano, Mitsuhiro
AU  - Kawano M
AUID- ORCID: 0000-0003-4613-2116
AD  - Department of Rheumatology, Kanazawa University Hospital, 13-1, Takara-machi, 
      Kanazawa, Ishikawa 920-8641, Japan.
LA  - eng
PT  - Case Reports
DEP - 20230130
PL  - England
TA  - Eur Heart J Case Rep
JT  - European heart journal. Case reports
JID - 101730741
PMC - PMC9969531
OTO - NOTNLM
OT  - Cardiac light-chain deposition disease
OT  - Cardiac magnetic resonance T1 mapping
OT  - Case report
OT  - Monoclonal gammopathy of clinical significance
OT  - Paraffin-immunofluorescence
COIS- Conflict of interest: None declared.
EDAT- 2023/03/03 06:00
MHDA- 2023/03/03 06:01
PMCR- 2023/01/30
CRDT- 2023/03/02 02:12
PHST- 2022/07/03 00:00 [received]
PHST- 2022/08/09 00:00 [revised]
PHST- 2023/01/25 00:00 [accepted]
PHST- 2023/03/02 02:12 [entrez]
PHST- 2023/03/03 06:00 [pubmed]
PHST- 2023/03/03 06:01 [medline]
PHST- 2023/01/30 00:00 [pmc-release]
AID - ytad049 [pii]
AID - 10.1093/ehjcr/ytad049 [doi]
PST - epublish
SO  - Eur Heart J Case Rep. 2023 Jan 30;7(2):ytad049. doi: 10.1093/ehjcr/ytad049. 
      eCollection 2023 Feb.