PMID- 36861004
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230303
IS  - 2156-4647 (Electronic)
IS  - 2156-4639 (Print)
VI  - 8
IP  - 3
DP  - 2022
TI  - Lung stereotactic body radiation therapy using simultaneous integrated 
      BED-escalation for peripherally located non-small cell lung cancer.
PG  - 181-187
AB  - PURPOSE: Report the outcomes of patients with non-small cell lung cancer (NSCLC) 
      and peripheral tumors treated with simultaneous integrated biologically 
      equivalent dose (BED)-escalation (SIBE) lung stereotactic body radiation therapy 
      (SBRT) to achieve dose escalation. MATERIALS/METHODS: Patients with NSCLC within 
      5 mm of the chest wall treated with a SIBE approach were eligible. Patients 
      received 60 Gy in 5 fractions, with dose decreased to 50 Gy based on proximity to 
      the chest wall. Dosimetry, oncologic outcomes, and toxicity were evaluated. 
      RESULTS: Twenty-four patients met inclusion criteria. Median BED to the PTV was 
      135.4 Gy. Median chest wall V30 was 18.7 cc. The 3-year LC, OS, and PFS of the 
      non-metastatic cohort was 93%, 35%, and 39%, respectively. The crude rate of 
      chest wall toxicity was 12.5%, with no rib fractures. CONCLUSIONS: SIBE lung SBRT 
      appears to be well tolerated and achieves favorable local control rates and 
      survival.
CI  - (c) 2022 Old City Publishing, Inc.
FAU - Ladbury, Colton J
AU  - Ladbury CJ
AD  - Department of Radiation Oncology, City of Hope National Medical Center, Duarte, 
      CA, USA.
FAU - Sampath, Sagus
AU  - Sampath S
AD  - Department of Radiation Oncology, City of Hope National Medical Center, Duarte, 
      CA, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Radiosurg SBRT
JT  - Journal of radiosurgery and SBRT
JID - 101565296
PMC - PMC9970741
OTO - NOTNLM
OT  - NSCLC
OT  - SIB
OT  - chest wall toxicity
OT  - dose escalation
OT  - lung SBRT
EDAT- 2022/01/01 00:00
MHDA- 2022/01/01 00:01
PMCR- 2023/01/01
CRDT- 2023/03/02 02:16
PHST- 2022/03/25 00:00 [received]
PHST- 2022/07/15 00:00 [accepted]
PHST- 2023/03/02 02:16 [entrez]
PHST- 2022/01/01 00:00 [pubmed]
PHST- 2022/01/01 00:01 [medline]
PHST- 2023/01/01 00:00 [pmc-release]
AID - RSBRT-8-181 [pii]
PST - ppublish
SO  - J Radiosurg SBRT. 2022;8(3):181-187.