PMID- 36864106
OWN - NLM
STAT- MEDLINE
DCOM- 20230306
LR  - 20230325
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Mar 2
TI  - Pediatric chronic graft-versus-host disease-related dry eye disease and the 
      diagnostic association of potential clinical findings.
PG  - 3575
LID - 10.1038/s41598-023-30288-6 [doi]
LID - 3575
AB  - Pediatric graft-versus-host-disease (GVHD)-related dry eye disease (DED) is often 
      overlooked due to a lack of subjective symptoms and reliable testing, leading to 
      irreversible corneal damage. To study the clinical findings contributing to the 
      accurate detection of pediatric GVHD-related DED, a retrospective study of 
      pediatric patients treated with hematopoietic stem cell transplantation (HSCT) at 
      Keio University Hospital between 2004 and 2017 was conducted. Association and 
      diagnostic values of ophthalmological findings for DED were analyzed. Twenty-six 
      patients who had no ocular complications before HSCT were included in the study. 
      Eleven (42.3%) patients developed new-onset DED. The cotton thread test showed 
      excellent diagnostic accuracy in detecting DED (area under the receiver operating 
      curve, 0.96; sensitivity, 0.95; specificity, 0.85) with a cut-off of 17 mm, which 
      was higher than the conventional threshold of 10 mm. Additionally, the presence 
      of filamentary keratitis (FK) and pseudomembranous conjunctivitis (PC) were 
      significantly associated with the diagnosis of DED (p value, 0.003 and 0.001 for 
      FK and PC, respectively) and displayed good diagnostic performance (sensitivity, 
      0.46 and 0.54; specificity, 0.97 and 0.97 for FK and PC, respectively). In 
      conclusion, the cotton thread test with a new threshold, the presence of PC and 
      FK, could be helpful for promptly detecting pediatric GVHD-related DED.
CI  - (c) 2023. The Author(s).
FAU - Yagi, Hitomi
AU  - Yagi H
AD  - Department of Ophthalmology, Keio University School of Medicine, 35, 
      Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
FAU - Shimizu, Eisuke
AU  - Shimizu E
AD  - Department of Ophthalmology, Keio University School of Medicine, 35, 
      Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
FAU - Yagi, Ryuichiro
AU  - Yagi R
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 
      MA, USA.
FAU - Uchino, Miki
AU  - Uchino M
AD  - Department of Ophthalmology, Keio University School of Medicine, 35, 
      Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
FAU - Kamoi, Mizuka
AU  - Kamoi M
AD  - Department of Ophthalmology, Keio University School of Medicine, 35, 
      Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
FAU - Asai, Kazuki
AU  - Asai K
AD  - Department of Ophthalmology, Keio University School of Medicine, 35, 
      Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
FAU - Tsubota, Kazuo
AU  - Tsubota K
AD  - Department of Ophthalmology, Keio University School of Medicine, 35, 
      Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
AD  - Tsubota Laboratory, Inc, Tokyo, Japan.
FAU - Negishi, Kazuno
AU  - Negishi K
AD  - Department of Ophthalmology, Keio University School of Medicine, 35, 
      Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
FAU - Ogawa, Yoko
AU  - Ogawa Y
AD  - Department of Ophthalmology, Keio University School of Medicine, 35, 
      Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan. yoko.z7@keio.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230302
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Humans
MH  - Child
MH  - *Bronchiolitis Obliterans Syndrome
MH  - Retrospective Studies
MH  - *Dry Eye Syndromes/diagnosis/etiology
MH  - *Graft vs Host Disease/diagnosis/etiology
MH  - Eye
MH  - *Conjunctivitis
MH  - Gossypium
PMC - PMC9981701
COIS- K.T. has a patent with a patent (Patent No. JP6967260) and a patent (Patent No. 
      JP6936496). Outside the submitted work, K.T. reports his position as CEO of 
      Tsubota Laboratory, Inc., Tokyo, Japan, a company working on treatments, 
      preventive agents, and medical devices for DED. Y.O. has a patent in Japan 
      (Patent No. 4966019; Title: Topical application and oral intake of tranilast for 
      the treatment of cGVHD-related dye eye disease). Y.O. and K.T. have patent 
      application numbers JP 2017-018643, published as JPA2017-178922. Y.O., E. S., and 
      K.T. have patent application numbers JP2018-510646 published as WO2017/175808. 
      E.S. has a grant from the Japanese Ministry of Education, Science, Sports, and 
      Culture 21K18394 and Bristol Myers Squibb. The other authors received no 
      financial support or additional benefit from commercial sources for the work 
      reported in this manuscript. Moreover, the authors have no financial interests 
      that may create a potential conflict or the appearance of a conflict of interest 
      regarding this work.
EDAT- 2023/03/03 06:00
MHDA- 2023/03/07 06:00
PMCR- 2023/03/02
CRDT- 2023/03/02 23:18
PHST- 2022/05/05 00:00 [received]
PHST- 2023/02/21 00:00 [accepted]
PHST- 2023/03/02 23:18 [entrez]
PHST- 2023/03/03 06:00 [pubmed]
PHST- 2023/03/07 06:00 [medline]
PHST- 2023/03/02 00:00 [pmc-release]
AID - 10.1038/s41598-023-30288-6 [pii]
AID - 30288 [pii]
AID - 10.1038/s41598-023-30288-6 [doi]
PST - epublish
SO  - Sci Rep. 2023 Mar 2;13(1):3575. doi: 10.1038/s41598-023-30288-6.