PMID- 36864557
OWN - NLM
STAT- MEDLINE
DCOM- 20230512
LR  - 20230513
IS  - 1753-0407 (Electronic)
IS  - 1753-0393 (Print)
IS  - 1753-0407 (Linking)
VI  - 15
IP  - 5
DP  - 2023 May
TI  - Autophagy in the retinal neurovascular unit: New perspectives into diabetic 
      retinopathy.
PG  - 382-396
LID - 10.1111/1753-0407.13373 [doi]
AB  - Diabetic retinopathy (DR) is one of the most prevalent retinal disorders 
      worldwide, and it is a major cause of vision impairment in individuals of 
      productive age. Research has demonstrated the significance of autophagy in DR, 
      which is a critical intracellular homeostasis mechanism required for the 
      destruction and recovery of cytoplasmic components. Autophagy maintains the 
      physiological function of senescent and impaired organelles under stress 
      situations, thereby regulating cell fate via various signals. As the retina's 
      functional and fundamental unit, the retinal neurovascular unit (NVU) is critical 
      in keeping the retinal environment's stability and supporting the needs of 
      retinal metabolism. However, autophagy is essential for the normal NVU structure 
      and function. We discuss the strong association between DR and autophagy in this 
      review, as well as the many kinds of autophagy and its crucial physiological 
      activities in the retina. By evaluating the pathological changes of retinal NVU 
      in DR and the latest advancements in the molecular mechanisms of autophagy that 
      may be involved in the pathophysiology of DR in NVU, we seek to propose new ideas 
      and methods for the prevention and treatment of DR.
CI  - (c) 2023 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai 
      JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd.
FAU - Yang, Xiongyi
AU  - Yang X
AD  - Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. 
      China.
AD  - The Second Clinical School, Southern Medical University, Guangzhou, Guangdong, P. 
      R. China.
FAU - Huang, Zexin
AU  - Huang Z
AD  - Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. 
      China.
AD  - The Second Clinical School, Southern Medical University, Guangzhou, Guangdong, P. 
      R. China.
FAU - Xu, Mei
AU  - Xu M
AD  - The Second People's Hospital of Jingmen, Jingmen, Hubei, People's Republic of 
      China.
FAU - Chen, Yanxia
AU  - Chen Y
AD  - Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, 
      Guangzhou, Guangdong, P. R. China.
FAU - Cao, Mingzhe
AU  - Cao M
AD  - Department of Ophthalmology, The Seventh Affiliated Hospital, Sun Yat-Sen 
      University, Shenzhen, P. R. China.
FAU - Yi, Guoguo
AU  - Yi G
AD  - Department of Ophthalmology, The Sixth Affiliated Hospital, Sun Yat-Sen 
      University, Guangzhou, Guangdong, P. R. China.
FAU - Fu, Min
AU  - Fu M
AUID- ORCID: 0000-0003-2638-1756
AD  - Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, 
      Guangzhou, Guangdong, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230302
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
MH  - Humans
MH  - *Diabetic Retinopathy/metabolism
MH  - Retina/metabolism/pathology
MH  - Autophagy/physiology
MH  - *Diabetes Mellitus/pathology
PMC - PMC10172025
OTO - NOTNLM
OT  - autophagy
OT  - diabetic retinopathy
OT  - mitophagy
OT  - retinal neurovascular unit
OT  - 糖尿病性视网膜病变
OT  - 线粒体自噬
OT  - 自噬
OT  - 视网膜神经血管单元
EDAT- 2023/03/03 06:00
MHDA- 2023/05/12 07:06
PMCR- 2023/03/02
CRDT- 2023/03/02 23:43
PHST- 2023/02/08 00:00 [revised]
PHST- 2022/12/12 00:00 [received]
PHST- 2023/02/18 00:00 [accepted]
PHST- 2023/05/12 07:06 [medline]
PHST- 2023/03/03 06:00 [pubmed]
PHST- 2023/03/02 23:43 [entrez]
PHST- 2023/03/02 00:00 [pmc-release]
AID - JDB13373 [pii]
AID - 10.1111/1753-0407.13373 [doi]
PST - ppublish
SO  - J Diabetes. 2023 May;15(5):382-396. doi: 10.1111/1753-0407.13373. Epub 2023 Mar 
      2.