PMID- 3686480
OWN - NLM
STAT- MEDLINE
DCOM- 19880111
LR  - 20190727
IS  - 0049-3848 (Print)
IS  - 0049-3848 (Linking)
VI  - 47
IP  - 6
DP  - 1987 Sep 15
TI  - Accumulation and release of acridine derivatives by intact platelets.
PG  - 639-45
AB  - A new approach to the investigation of accumulation of acridine derivatives and 
      release by platelets is proposed. At high concentrations of acridine orange (AO) 
      inside dense bodies, a two component fluorescence spectrum with maxima at 530 and 
      640 nm has been recorded. Computer deconvolution of spectra provided additional 
      information on the mechanism of dye accumulation and release. AO release from 
      PAF-stimulated human platelets was analysed in details. A 10 +/- 2.5-s delay in 
      alteration of the shortwave component was observed. Changes in the longwave 
      component were not preceded by a lag period. These data suggest a possibility of 
      dye redistribution in the cell after stimulation.
FAU - Popov, E G
AU  - Popov EG
AD  - USSR Cardiology Research Center, Academy of Medical Sciences, Moscow.
FAU - Gabbasov, Z A
AU  - Gabbasov ZA
FAU - Gavrilov IYu
AU  - Gavrilov IYu
FAU - Pozin EYa
AU  - Pozin EYa
FAU - Mejlumian, A G
AU  - Mejlumian AG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 0 (Acridines)
RN  - F30N4O6XVV (Acridine Orange)
RN  - H0C805XYDE (Quinacrine)
SB  - IM
MH  - Acridine Orange/*metabolism
MH  - Acridines/*metabolism
MH  - Blood Platelets/*metabolism
MH  - Fluorescence
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Microscopy, Fluorescence
MH  - Osmolar Concentration
MH  - Quinacrine/*metabolism
EDAT- 1987/09/15 00:00
MHDA- 1987/09/15 00:01
CRDT- 1987/09/15 00:00
PHST- 1987/09/15 00:00 [pubmed]
PHST- 1987/09/15 00:01 [medline]
PHST- 1987/09/15 00:00 [entrez]
AID - 10.1016/0049-3848(87)90102-2 [doi]
PST - ppublish
SO  - Thromb Res. 1987 Sep 15;47(6):639-45. doi: 10.1016/0049-3848(87)90102-2.