PMID- 36865565
OWN - NLM
STAT- MEDLINE
DCOM- 20230307
LR  - 20230307
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 14
DP  - 2023
TI  - The central role of natural killer cells in preeclampsia.
PG  - 1009867
LID - 10.3389/fimmu.2023.1009867 [doi]
LID - 1009867
AB  - Preeclampsia (PE) is a disease that is unique to pregnancy and affects multiple 
      systems. It can lead to maternal and perinatal mortality. The precise etiology of 
      PE is unclear. Patients with PE may have systemic or local immune abnormalities. 
      A group of researchers has proposed that the immune communication between the 
      fetus and mother is primarily moderated by natural killer (NK) cells as opposed 
      to T cells, since NK cells are the most abundant immune cells in the uterus. This 
      review examines the immunological roles of NK cells in the pathogenesis of PE. 
      Our aim is to provide obstetricians with a comprehensive and updated research 
      progress report on NK cells in PE patients. It has been reported that decidual NK 
      (dNK) cells contribute to the process of uterine spiral artery remodeling and can 
      modulate trophoblast invasion. Additionally, dNK cells can stimulate fetal growth 
      and regulate delivery. It appears that the count or proportion of circulating NK 
      cells is elevated in patients with or at risk for PE. Changes in the number or 
      function of dNK cells may be the cause of PE. The Th1/Th2 equilibrium in PE has 
      gradually shifted to an NK1/NK2 equilibrium based on cytokine production. An 
      improper combination of killer cell immunoglobulin-like receptor (KIR) and human 
      leukocyte antigen (HLA)-C may lead to insufficient activation of dNK cells, 
      thereby causing PE. In the etiology of PE, NK cells appear to exert a central 
      effect in both peripheral blood and the maternal-fetal interface. To maintain 
      immune equilibrium both locally and systemically, it is necessary to take 
      therapeutic measures directed at NK cells.
CI  - Copyright (c) 2023 Wei and Yang.
FAU - Wei, Xiaoqi
AU  - Wei X
AD  - Department of Obstetrics, The First Hospital of China Medical University, 
      Shenyang, China.
FAU - Yang, Xiuhua
AU  - Yang X
AD  - Department of Obstetrics, The First Hospital of China Medical University, 
      Shenyang, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230214
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Arteries
MH  - Communication
MH  - HLA-C Antigens
MH  - *Killer Cells, Natural
MH  - *Pre-Eclampsia
PMC - PMC9972679
OTO - NOTNLM
OT  - NK cells
OT  - immune
OT  - placenta
OT  - preeclampsia
OT  - pregnancy
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/03/04 06:00
MHDA- 2023/03/07 06:00
PMCR- 2023/01/01
CRDT- 2023/03/03 02:32
PHST- 2022/08/02 00:00 [received]
PHST- 2023/01/31 00:00 [accepted]
PHST- 2023/03/03 02:32 [entrez]
PHST- 2023/03/04 06:00 [pubmed]
PHST- 2023/03/07 06:00 [medline]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2023.1009867 [doi]
PST - epublish
SO  - Front Immunol. 2023 Feb 14;14:1009867. doi: 10.3389/fimmu.2023.1009867. 
      eCollection 2023.