PMID- 36865988
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230304
IS  - 2665-9131 (Electronic)
IS  - 2665-9131 (Linking)
VI  - 5
IP  - 2
DP  - 2023 Jun
TI  - Genicular artery embolization for treatment of knee osteoarthritis pain: 
      Systematic review and meta-analysis.
PG  - 100342
LID - 10.1016/j.ocarto.2023.100342 [doi]
LID - 100342
AB  - OBJECTIVE: Genicular artery embolization (GAE) is a novel, minimally invasive 
      procedure for treatment of knee osteoarthritis (OA). This meta-analysis 
      investigated the safety and effectiveness of this procedure. DESIGN: Outcomes of 
      this systematic review with meta-analysis were technical success, knee pain 
      visual analog scale (VAS; 0-100 scale), WOMAC Total Score (0-100 scale), 
      retreatment rate, and adverse events. Continuous outcomes were calculated as the 
      weighted mean difference (WMD) versus baseline. Minimal clinically important 
      difference (MCID) and substantial clinical benefit (SCB) rates were estimated in 
      Monte Carlo simulations. Rates of total knee replacement and repeat GAE were 
      calculated using life-table methods. RESULTS: In 10 groups (9 studies; 270 
      patients; 339 knees), GAE technical success was 99.7%. Over 12 months, the WMD 
      ranged from -34 to -39 at each follow-up for VAS score and -28 to -34 for WOMAC 
      Total score (all p ​< ​0.001). At 12 months, 78% met the MCID for VAS score; 92% 
      met the MCID for WOMAC Total score, and 78% met the SCB for WOMAC Total score. 
      Higher baseline knee pain severity was associated with greater improvements in 
      knee pain. Over 2 years, 5.2% of patients underwent total knee replacement and 
      8.3% received repeat GAE. Adverse events were minor, with transient skin 
      discoloration as the most common (11.6%). CONCLUSIONS: Limited evidence suggests 
      that GAE is a safe procedure that confers improvement in knee OA symptoms at 
      established MCID thresholds. Patients with greater knee pain severity may be more 
      responsive to GAE.
CI  - (c) 2023 The Author(s).
FAU - Taslakian, Bedros
AU  - Taslakian B
AD  - Division of Vascular and Interventional Radiology, Department of Radiology, NYU 
      Langone Health, New York, NY, United States.
FAU - Miller, Larry E
AU  - Miller LE
AD  - Miller Scientific, Johnson City, TN, United States.
FAU - Mabud, Tarub S
AU  - Mabud TS
AD  - Division of Vascular and Interventional Radiology, Department of Radiology, NYU 
      Langone Health, New York, NY, United States.
FAU - Macaulay, William
AU  - Macaulay W
AD  - Division of Adult Reconstruction, Department of Orthopedic Surgery, NYU Langone 
      Health, New York, NY, United States.
FAU - Samuels, Jonathan
AU  - Samuels J
AD  - Division of Rheumatology, Department of Medicine, NYU Langone Health, New York, 
      NY, United States.
FAU - Attur, Mukundan
AU  - Attur M
AD  - Division of Rheumatology, Department of Medicine, NYU Langone Health, New York, 
      NY, United States.
FAU - Alaia, Erin F
AU  - Alaia EF
AD  - Division of Musculoskeletal Radiology, Department of Radiology, NYU Langone 
      Health, New York, NY, United States.
FAU - Kijowski, Richard
AU  - Kijowski R
AD  - Division of Musculoskeletal Radiology, Department of Radiology, NYU Langone 
      Health, New York, NY, United States.
FAU - Hickey, Ryan
AU  - Hickey R
AD  - Division of Vascular and Interventional Radiology, Department of Radiology, NYU 
      Langone Health, New York, NY, United States.
FAU - Sista, Akhilesh K
AU  - Sista AK
AD  - Division of Vascular and Interventional Radiology, Department of Radiology, Weill 
      Cornell Medicine, New York, NY, United States.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230206
PL  - England
TA  - Osteoarthr Cartil Open
JT  - Osteoarthritis and cartilage open
JID - 101767068
PMC - PMC9971280
OTO - NOTNLM
OT  - GAE
OT  - Genicular artery embolization
OT  - Knee
OT  - Osteoarthritis
OT  - Pain
COIS- L. Miller received research support from NYU Langone Health, related to the 
      present manuscript. B. Taslakian received research support from 
      10.13039/100007210Varian Medical Systems, related to the present manuscript. W. 
      Macauly discloses board membership with AAHKS, CORR, JoA, and Hip Society, and 
      stock ownership of OrthAlign, unrelated to the present manuscript. A. Sista 
      discloses grant payment from NIH, unrelated to the present manuscript. B. 
      Taslakian discloses payment from Advarra for DSMB participation, unrelated to the 
      present manuscript. E. Alaia, M. Attur, R. Hickey, R. Kijowski, T. Mabud, and J. 
      Samuels report no conflicts of interest.
EDAT- 2023/03/04 06:00
MHDA- 2023/03/04 06:01
PMCR- 2023/02/06
CRDT- 2023/03/03 02:39
PHST- 2023/01/24 00:00 [received]
PHST- 2023/01/30 00:00 [revised]
PHST- 2023/01/31 00:00 [accepted]
PHST- 2023/03/03 02:39 [entrez]
PHST- 2023/03/04 06:00 [pubmed]
PHST- 2023/03/04 06:01 [medline]
PHST- 2023/02/06 00:00 [pmc-release]
AID - S2665-9131(23)00009-2 [pii]
AID - 100342 [pii]
AID - 10.1016/j.ocarto.2023.100342 [doi]
PST - epublish
SO  - Osteoarthr Cartil Open. 2023 Feb 6;5(2):100342. doi: 
      10.1016/j.ocarto.2023.100342. eCollection 2023 Jun.