PMID- 36866246
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230304
IS  - 2589-0042 (Electronic)
IS  - 2589-0042 (Linking)
VI  - 26
IP  - 3
DP  - 2023 Mar 17
TI  - Muscarinic acetylcholine receptor-dependent and NMDA receptor-dependent LTP and 
      LTD share the common AMPAR trafficking pathway.
PG  - 106133
LID - 10.1016/j.isci.2023.106133 [doi]
LID - 106133
AB  - The forebrain cholinergic system promotes higher brain function in part by 
      signaling through the M(1) muscarinic acetylcholine receptor (mAChR). Long-term 
      potentiation (LTP) and long-term depression (LTD) of excitatory synaptic 
      transmission in the hippocampus are also induced by mAChR. An AMPA receptor 
      (AMPAR) trafficking model for hippocampal neurons has been proposed to simulate 
      N-methyl-D-aspartate receptor (NMDAR)-dependent synaptic plasticity in the early 
      phase. In this study, we demonstrated the validity of the hypothesis that the 
      mAChR-dependent LTP/LTD shares a common AMPAR trafficking pathway associated with 
      NMDAR-dependent LTP/LTD. However, unlike NMDAR, Ca(2+) influx into the spine 
      cytosol occurs owing to the Ca(2+) stored inside the ER and is induced via the 
      activation of inositol 1,4,5-trisphosphate (IP3) receptors during M1 mAChR 
      activation. Moreover, the AMPAR trafficking model implies that alterations in LTP 
      and LTD observed in Alzheimer's disease could be attributed to age-dependent 
      reductions in AMPAR expression levels.
CI  - (c) 2023 The Author(s).
FAU - Sumi, Tomonari
AU  - Sumi T
AD  - Research Institute for Interdisciplinary Science, Okayama University, 3-1-1 
      Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan.
AD  - Department of Chemistry, Faculty of Science, Okayama University, 3-1-1 
      Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan.
FAU - Harada, Kouji
AU  - Harada K
AD  - Department of Computer Science and Engineering, Toyohashi University of 
      Technology, Tempaku-cho, Toyohashi 441-8580, Japan.
AD  - Center for IT-Based Education, Toyohashi University of Technology, Tempaku-cho, 
      Toyohashi, 441-8580, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230203
PL  - United States
TA  - iScience
JT  - iScience
JID - 101724038
PMC - PMC9972575
OTO - NOTNLM
OT  - Cellular neuroscience
OT  - Cellular physiology
OT  - Molecular neuroscience
COIS- The authors declare no competing interests.
EDAT- 2023/03/04 06:00
MHDA- 2023/03/04 06:01
PMCR- 2023/02/03
CRDT- 2023/03/03 02:43
PHST- 2022/06/20 00:00 [received]
PHST- 2022/10/30 00:00 [revised]
PHST- 2023/01/31 00:00 [accepted]
PHST- 2023/03/03 02:43 [entrez]
PHST- 2023/03/04 06:00 [pubmed]
PHST- 2023/03/04 06:01 [medline]
PHST- 2023/02/03 00:00 [pmc-release]
AID - S2589-0042(23)00210-9 [pii]
AID - 106133 [pii]
AID - 10.1016/j.isci.2023.106133 [doi]
PST - epublish
SO  - iScience. 2023 Feb 3;26(3):106133. doi: 10.1016/j.isci.2023.106133. eCollection 
      2023 Mar 17.