PMID- 36866677
OWN - NLM
STAT- MEDLINE
DCOM- 20230508
LR  - 20230509
IS  - 1099-1077 (Electronic)
IS  - 0885-6222 (Linking)
VI  - 38
IP  - 3
DP  - 2023 May
TI  - A narrative review of the neuropharmacology of synthetic cathinones-Popular 
      alternatives to classical drugs of abuse.
PG  - e2866
LID - 10.1002/hup.2866 [doi]
AB  - OBJECTIVE: To review the literature on the neuropharmacology of synthetic 
      cathinones. METHODS: A comprehensive literature search was carried out across 
      multiple databases (mainly PubMed, World Wide Web, and Google Scholar) using 
      relevant keywords. RESULTS: Cathinones exhibit a broad toxicological profile, 
      mimicking the effects of a wide variety of 'classic drugs' such as 
      3,4-methylenedioxymethamphetamine (MDMA), methamphetamine and cocaine. Even small 
      structural changes affect their interactions with key proteins. This article 
      reviews existing knowledge of the mechanisms of action of cathinones at the 
      molecular level, and key findings from research on their structure-activity 
      relationship. The cathinones are also classified according to their chemical 
      structure and neuropharmacological profiles. CONCLUSIONS: Synthetic cathinones 
      represent one of the most numerous and widespread groups among new psychoactive 
      substances. Initially developed for therapeutic purposes, they quickly started to 
      be used recreationally. With a rapidly increasing number of new agents entering 
      the market, structure-activity relationship studies are valuable for assessing 
      and predicting the addictive potential and toxicity of new and potential future 
      substances. The neuropharmacological properties of synthetic cathinones are still 
      not fully understood. A full elucidation of the role of some key proteins, 
      including organic cation transporters, requires detailed studies.
CI  - (c) 2023 John Wiley & Sons Ltd.
FAU - Kuropka, Patryk
AU  - Kuropka P
AD  - Institute of Toxicology Research, Borowa, Poland.
FAU - Zawadzki, Marcin
AU  - Zawadzki M
AD  - Institute of Toxicology Research, Borowa, Poland.
AD  - Department of Forensic Medicine, Wroclaw Medical University, Wroclaw, Poland.
FAU - Szpot, Pawel
AU  - Szpot P
AD  - Institute of Toxicology Research, Borowa, Poland.
AD  - Department of Forensic Medicine, Wroclaw Medical University, Wroclaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230303
PL  - England
TA  - Hum Psychopharmacol
JT  - Human psychopharmacology
JID - 8702539
RN  - 0 (Synthetic Cathinone)
RN  - 0 (Alkaloids)
RN  - 44RAL3456C (Methamphetamine)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Humans
MH  - Synthetic Cathinone
MH  - Neuropharmacology
MH  - *Alkaloids/adverse effects
MH  - *Methamphetamine/adverse effects
MH  - *Central Nervous System Stimulants/adverse effects
MH  - Psychotropic Drugs/adverse effects
OTO - NOTNLM
OT  - NPS
OT  - SAR
OT  - monoamine transporters
OT  - neuropharmacology
OT  - organic cation transporters
OT  - synthetic cathinones
EDAT- 2023/03/04 06:00
MHDA- 2023/05/08 06:42
CRDT- 2023/03/03 05:03
PHST- 2023/02/15 00:00 [revised]
PHST- 2022/06/01 00:00 [received]
PHST- 2023/02/16 00:00 [accepted]
PHST- 2023/05/08 06:42 [medline]
PHST- 2023/03/04 06:00 [pubmed]
PHST- 2023/03/03 05:03 [entrez]
AID - 10.1002/hup.2866 [doi]
PST - ppublish
SO  - Hum Psychopharmacol. 2023 May;38(3):e2866. doi: 10.1002/hup.2866. Epub 2023 Mar 
      3.