PMID- 36867133 OWN - NLM STAT- MEDLINE DCOM- 20230307 LR - 20230512 IS - 1552-5783 (Electronic) IS - 0146-0404 (Print) IS - 0146-0404 (Linking) VI - 64 IP - 3 DP - 2023 Mar 1 TI - Physical Activity Is Associated With Macular Thickness: A Multi-Cohort Observational Study. PG - 11 LID - 10.1167/iovs.64.3.11 [doi] LID - 11 AB - PURPOSE: To assess the association between physical activity and spectral-domain optical coherence tomography (SD-OCT)-measured rates of macular thinning in an adult population with primary open-angle glaucoma. METHODS: The correlation between accelerometer-measured physical activity and rates of macular ganglion cell-inner plexiform layer (GCIPL) thinning was measured in 735 eyes from 388 participants of the Progression Risk of Glaucoma: RElevant SNPs with Significant Association (PROGRESSA) study. The association between accelerometer-measured physical activity and cross-sectional SD-OCT macular thickness was then assessed in 8862 eyes from 6152 participants available for analysis in the UK Biobank who had SD-OCT, ophthalmic, comorbidity, and demographic data. RESULTS: Greater physical activity was associated with slower rates of macular GCIPL thinning in the PROGRESSA study (beta = 0.07 microm/y/SD; 95% confidence interval [CI], 0.03-0.13; P = 0.003) after adjustment for ophthalmic, demographic and systemic predictors of macular thinning. This association persisted in subanalyses of participants characterized as glaucoma suspects (beta = 0.09 microm/y/SD; 95% CI, 0.03-0.15; P = 0.005). Participants in the upper tertile (greater than 10,524 steps/d) exhibited a 0.22-microm/y slower rate of macular GCIPL thinning than participants in the lower tertile (fewer than 6925 steps/d): -0.40 +/- 0.46 microm/y versus -0.62 +/- 0.55 microm/y (P = 0.003). Both time spent doing moderate/vigorous activity and mean daily active calories were positively correlated with rate of macular GCIPL thinning (moderate/vigorous activity: beta = 0.06 microm/y/SD; 95% CI, 0.01-0.105; P = 0.018; active calories: beta = 0.06 microm/y/SD; 95% CI, 0.006-0.114; P = 0.032). Analysis among 8862 eyes from the UK Biobank revealed a positive association between physical activity and cross-sectional total macular thickness (beta = 0.8 microm/SD; 95% CI, 0.47-1.14; P < 0.001). CONCLUSIONS: These results highlight the potential neuroprotective benefits of exercise on the human retina. FAU - Berry, Ella C AU - Berry EC AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Marshall, Henry N AU - Marshall HN AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Mullany, Sean AU - Mullany S AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Torres, Santiago Diaz AU - Torres SD AD - QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. FAU - Schmidt, Joshua AU - Schmidt J AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Thomson, Daniel AU - Thomson D AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Knight, Lachlan S W AU - Knight LSW AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Hollitt, Georgina L AU - Hollitt GL AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Qassim, Ayub AU - Qassim A AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Ridge, Bronwyn AU - Ridge B AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Schulz, Angela AU - Schulz A AD - Faculty of Health and Medical Sciences, Macquarie University, Sydney, Australia. FAU - Hassall, Mark M AU - Hassall MM AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Nguyen, Thi Thi AU - Nguyen TT AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Lake, Stewart AU - Lake S AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Mills, Richard A AU - Mills RA AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Agar, Ashish AU - Agar A AD - Department of Ophthalmology, University of New South Wales, Sydney, New South Wales, Australia. FAU - Galanopoulos, Anna AU - Galanopoulos A AD - Discipline of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, South Australia, Australia. FAU - Landers, John AU - Landers J AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Healey, Paul R AU - Healey PR AD - Centre for Vision Research, University of Sydney, Sydney, New South Wales, Australia. FAU - Graham, Stuart L AU - Graham SL AD - Faculty of Health and Medical Sciences, Macquarie University, Sydney, Australia. FAU - Hewitt, Alex W AU - Hewitt AW AD - Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. FAU - MacGregor, Stuart AU - MacGregor S AD - QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. FAU - Casson, Robert J AU - Casson RJ AD - Discipline of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, South Australia, Australia. FAU - Siggs, Owen M AU - Siggs OM AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. AD - Garvan Institute of Medical Research, Sydney, New South Wales, Australia. FAU - Craig, Jamie E AU - Craig JE AD - Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia. LA - eng GR - BHF_/British Heart Foundation/United Kingdom GR - DH_/Department of Health/United Kingdom PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't PL - United States TA - Invest Ophthalmol Vis Sci JT - Investigative ophthalmology & visual science JID - 7703701 SB - IM MH - Adult MH - Humans MH - Cross-Sectional Studies MH - *Glaucoma, Open-Angle MH - Retina MH - *Glaucoma MH - Exercise PMC - PMC9988706 COIS- Disclosure: E.C. Berry, None; H.N. Marshall, None; S. Mullany, None; S.D. Torres, None; J. Schmidt, None; D. Thomson, None; L.S.W. Knight, None; G.L. Hollitt, None; A. Qassim, None; B. Ridge, None; A. Schulz, None; M.M. Hassall, None; T.T. Nguyen, None; S. Lake, None; R.A. Mills, None; A. Agar, None; A. Galanopoulos, None; J. Landers, None; P.R. Healey, None; S.L. Graham, None; A.W. Hewitt, None; S. MacGregor, None; R.J. Casson, None; O.M. Siggs, None; J.E. Craig, None EDAT- 2023/03/04 06:00 MHDA- 2023/03/08 06:00 PMCR- 2023/03/03 CRDT- 2023/03/03 10:32 PHST- 2023/03/03 10:32 [entrez] PHST- 2023/03/04 06:00 [pubmed] PHST- 2023/03/08 06:00 [medline] PHST- 2023/03/03 00:00 [pmc-release] AID - 2785418 [pii] AID - IOVS-22-35231 [pii] AID - 10.1167/iovs.64.3.11 [doi] PST - ppublish SO - Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):11. doi: 10.1167/iovs.64.3.11.