PMID- 36868081
OWN - NLM
STAT- MEDLINE
DCOM- 20230530
LR  - 20230602
IS  - 1879-0364 (Electronic)
IS  - 1369-5274 (Linking)
VI  - 73
DP  - 2023 Jun
TI  - Impact of caloric restriction on the gut microbiota.
PG  - 102287
LID - S1369-5274(23)00024-3 [pii]
LID - 10.1016/j.mib.2023.102287 [doi]
AB  - Caloric restriction (CR) and related time-restricted diets have been popularized 
      as means of preventing metabolic disease while improving general well-being. 
      However, evidence as to their long-term efficacy, adverse effects, and mechanisms 
      of activity remains incompletely understood. The gut microbiota is modulated by 
      such dietary approaches, yet causal evidence to its possible downstream impacts 
      on host metabolism remains elusive. Herein, we discuss the positive and adverse 
      influences of restrictive dietary interventions on gut microbiota composition and 
      function, and their collective impacts on host health and disease risk. We 
      highlight known mechanisms of microbiota influences on the host, such as 
      modulation of bioactive metabolites, while discussing challenges in achieving 
      mechanistic dietary-microbiota insights, including interindividual variability in 
      dietary responses as well as other methodological and conceptual challenges. In 
      all, causally understanding the impact of CR approaches on the gut microbiota may 
      enable to better decode their overall influences on human physiology and disease.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Kern, Lara
AU  - Kern L
AD  - Systems Immunology Department, Weizmann Institute of Science, Rehovot, Israel.
FAU - Kviatcovsky, Denise
AU  - Kviatcovsky D
AD  - Systems Immunology Department, Weizmann Institute of Science, Rehovot, Israel.
FAU - He, Yiming
AU  - He Y
AD  - Systems Immunology Department, Weizmann Institute of Science, Rehovot, Israel.
FAU - Elinav, Eran
AU  - Elinav E
AD  - Systems Immunology Department, Weizmann Institute of Science, Rehovot, Israel; 
      Microbiota & Cancer Division, DKFZ, Heidelberg, Germany. Electronic address: 
      eran.elinav@weizmann.ac.il.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230301
PL  - England
TA  - Curr Opin Microbiol
JT  - Current opinion in microbiology
JID - 9815056
SB  - IM
MH  - Humans
MH  - *Gastrointestinal Microbiome
MH  - Caloric Restriction
MH  - Diet
MH  - *Microbiota
EDAT- 2023/03/04 06:00
MHDA- 2023/05/30 06:42
CRDT- 2023/03/03 18:16
PHST- 2022/11/30 00:00 [received]
PHST- 2023/01/27 00:00 [revised]
PHST- 2023/01/31 00:00 [accepted]
PHST- 2023/05/30 06:42 [medline]
PHST- 2023/03/04 06:00 [pubmed]
PHST- 2023/03/03 18:16 [entrez]
AID - S1369-5274(23)00024-3 [pii]
AID - 10.1016/j.mib.2023.102287 [doi]
PST - ppublish
SO  - Curr Opin Microbiol. 2023 Jun;73:102287. doi: 10.1016/j.mib.2023.102287. Epub 
      2023 Mar 1.