PMID- 36868277
OWN - NLM
STAT- MEDLINE
DCOM- 20230425
LR  - 20230425
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 875
DP  - 2023 Jun 1
TI  - Sulfate-modified nanosized polystyrene impairs memory by inhibiting ionotropic 
      glutamate receptors and the cAMP-response element binding protein (CREB) pathway 
      in Caenorhabditis elegans.
PG  - 162404
LID - S0048-9697(23)01020-3 [pii]
LID - 10.1016/j.scitotenv.2023.162404 [doi]
AB  - Nanoplastic contamination is an emerging environmental concern worldwide. In 
      particular, sulfate anionic surfactants often appear along with nanosized plastic 
      particles in personal care products, suggesting that sulfate-modified nanosized 
      polystyrene (S-NP) may occur, remain, and spread into the environment. However, 
      whether S-NP adversely affects learning and memory is unknown. In this study, we 
      used a positive butanone training protocol to evaluate the effects of S-NP 
      exposure on short-term associative memory (STAM) and long-term associative memory 
      (LTAM) in Caenorhabditis elegans. We observed that long-term S-NP exposure 
      impairs both STAM and LTAM in C. elegans. We also observed that mutations in the 
      glr-1, nmr-1, acy-1, unc-43, and crh-1 genes eliminated the STAM and LTAM 
      impairment induced by S-NP, and the mRNA levels of these genes were also 
      decreased upon S-NP exposure. These genes encode ionotropic glutamate receptors 
      (iGluRs), cyclic adenosine monophosphate (cAMP)/Ca(2+) signaling proteins, and 
      cAMP-response element binding protein (CREB)/CRH-1 signaling proteins. Moreover, 
      S-NP exposure inhibited the expression of the CREB-dependent LTAM genes nid-1, 
      ptr-15, and unc-86. Our findings provide new insights into long-term S-NP 
      exposure and the impairment of STAM and LTAM, which involve the highly conserved 
      iGluRs and CRH-1/CREB signaling pathways.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Lin, Ting-An
AU  - Lin TA
AD  - Department of Bioenvironmental Systems Engineering, National Taiwan University, 
      Taipei 106, Taiwan.
FAU - How, Chun Ming
AU  - How CM
AD  - Department of Bioenvironmental Systems Engineering, National Taiwan University, 
      Taipei 106, Taiwan.
FAU - Yen, Pei-Ling
AU  - Yen PL
AD  - Department of Bioenvironmental Systems Engineering, National Taiwan University, 
      Taipei 106, Taiwan.
FAU - Liao, Vivian Hsiu-Chuan
AU  - Liao VH
AD  - Department of Bioenvironmental Systems Engineering, National Taiwan University, 
      Taipei 106, Taiwan. Electronic address: vivianliao@ntu.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20230301
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Polystyrenes)
RN  - 0 (Receptors, Ionotropic Glutamate)
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Sulfates)
RN  - 0 (CRH-1 protein, C elegans)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - *Caenorhabditis elegans/physiology
MH  - Polystyrenes/toxicity/metabolism
MH  - Receptors, Ionotropic Glutamate/genetics/metabolism
MH  - *Caenorhabditis elegans Proteins/genetics/metabolism
MH  - Sulfates/metabolism
MH  - Response Elements
MH  - Transcription Factors/metabolism
OTO - NOTNLM
OT  - Caenorhabditis elegans
OT  - Learning and memory
OT  - Nanoplastics
OT  - Signaling pathways
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/03/04 06:00
MHDA- 2023/04/25 10:20
CRDT- 2023/03/03 19:26
PHST- 2022/11/15 00:00 [received]
PHST- 2023/02/16 00:00 [revised]
PHST- 2023/02/18 00:00 [accepted]
PHST- 2023/04/25 10:20 [medline]
PHST- 2023/03/04 06:00 [pubmed]
PHST- 2023/03/03 19:26 [entrez]
AID - S0048-9697(23)01020-3 [pii]
AID - 10.1016/j.scitotenv.2023.162404 [doi]
PST - ppublish
SO  - Sci Total Environ. 2023 Jun 1;875:162404. doi: 10.1016/j.scitotenv.2023.162404. 
      Epub 2023 Mar 1.