PMID- 36868465
OWN - NLM
STAT- MEDLINE
DCOM- 20230609
LR  - 20230621
IS  - 1525-2191 (Electronic)
IS  - 0002-9440 (Linking)
VI  - 193
IP  - 6
DP  - 2023 Jun
TI  - Vitamin D and Microbiome: Molecular Interaction in Inflammatory Bowel Disease 
      Pathogenesis.
PG  - 656-668
LID - S0002-9440(23)00055-X [pii]
LID - 10.1016/j.ajpath.2023.02.004 [doi]
AB  - Studies of systemic autoimmune diseases point to characteristic microbial 
      patterns in various diseases, including inflammatory bowel disease (IBD). 
      Autoimmune diseases, and IBD in particular, show a predisposition to vitamin D 
      deficiency, leading to alterations in the microbiome and disruption of intestinal 
      epithelial barrier integrity. This review examines the role of the gut microbiome 
      in IBD and discusses how vitamin D-vitamin D receptor (VDR)-associated molecular 
      signaling pathways contribute to the development and progression of IBD through 
      their effects on gut barrier function, the microbial community, and immune system 
      function. The present data demonstrate that vitamin D promotes the proper 
      function of the innate immune system by acting as an immunomodulator, exerting 
      anti-inflammatory effects, and critically contributing to the maintenance of gut 
      barrier integrity and modulation of the gut microbiota, mechanisms that may 
      influence the IBD development and progression. VDR regulates the biological 
      effects of vitamin D and is related to environmental, genetic, immunologic, and 
      microbial aspects of IBD. Vitamin D influences the distribution of the fecal 
      microbiota, with high vitamin D levels associated with increased levels of 
      beneficial bacterial species and lower levels of pathogenic bacteria. 
      Understanding the cellular functions of vitamin D-VDR signaling in intestinal 
      epithelial cells may pave the way for the development of new treatment strategies 
      for the therapeutic armamentarium of IBD in the near future.
CI  - Copyright (c) 2023 American Society for Investigative Pathology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Aggeletopoulou, Ioanna
AU  - Aggeletopoulou I
AD  - Division of Gastroenterology, Department of Internal Medicine, University 
      Hospital of Patras, Patras, Greece; Laboratory of Immunohematology, Division of 
      Hematology, Department of Internal Medicine, Medical School, University of 
      Patras, Patras, Greece. Electronic address: iaggel@upatras.gr.
FAU - Marangos, Markos
AU  - Marangos M
AD  - Division of Infectious Diseases, Department of Internal Medicine, University 
      Hospital of Patras, Patras, Greece.
FAU - Assimakopoulos, Stelios F
AU  - Assimakopoulos SF
AD  - Division of Infectious Diseases, Department of Internal Medicine, University 
      Hospital of Patras, Patras, Greece.
FAU - Mouzaki, Athanasia
AU  - Mouzaki A
AD  - Laboratory of Immunohematology, Division of Hematology, Department of Internal 
      Medicine, Medical School, University of Patras, Patras, Greece.
FAU - Thomopoulos, Konstantinos
AU  - Thomopoulos K
AD  - Division of Gastroenterology, Department of Internal Medicine, University 
      Hospital of Patras, Patras, Greece.
FAU - Triantos, Christos
AU  - Triantos C
AD  - Division of Gastroenterology, Department of Internal Medicine, University 
      Hospital of Patras, Patras, Greece.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230301
PL  - United States
TA  - Am J Pathol
JT  - The American journal of pathology
JID - 0370502
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Humans
MH  - Vitamin D/metabolism
MH  - *Inflammatory Bowel Diseases
MH  - *Gastrointestinal Microbiome
MH  - Signal Transduction
MH  - *Autoimmune Diseases
EDAT- 2023/03/04 06:00
MHDA- 2023/06/09 06:42
CRDT- 2023/03/03 19:30
PHST- 2022/11/21 00:00 [received]
PHST- 2023/02/13 00:00 [revised]
PHST- 2023/02/16 00:00 [accepted]
PHST- 2023/06/09 06:42 [medline]
PHST- 2023/03/04 06:00 [pubmed]
PHST- 2023/03/03 19:30 [entrez]
AID - S0002-9440(23)00055-X [pii]
AID - 10.1016/j.ajpath.2023.02.004 [doi]
PST - ppublish
SO  - Am J Pathol. 2023 Jun;193(6):656-668. doi: 10.1016/j.ajpath.2023.02.004. Epub 
      2023 Mar 1.