PMID- 36869157
OWN - NLM
STAT- MEDLINE
DCOM- 20230403
LR  - 20230403
IS  - 1432-1971 (Electronic)
IS  - 0172-0643 (Linking)
VI  - 44
IP  - 4
DP  - 2023 Apr
TI  - Predictors of Serious Adverse Events and High-Level Cardiorespiratory Support in 
      Patients Undergoing Transcatheter Pulmonary Vein Interventions.
PG  - 806-815
LID - 10.1007/s00246-023-03129-6 [doi]
AB  - Patients with pulmonary vein stenosis (PVS) often require frequent transcatheter 
      pulmonary vein (PV) interventions for management of restenosis. Predictors of 
      serious adverse events (AEs) and need for high-level cardiorespiratory support 
      (mechanical ventilation, vasoactive support, and/or extracorporeal membrane 
      oxygenation) 48 h after transcatheter PV interventions have not been reported. 
      This is a single-center retrospective cohort analysis of patients with PVS who 
      underwent transcatheter PV interventions from 3/1/2014 to 12/31/2021. Univariate 
      and multivariable analyses were performed using generalized estimating equations 
      to account for within-patient correlation. 240 patients underwent 841 
      catheterizations involving PV interventions (median 2 catheterizations per 
      patient [1,3]). At least one serious AE was reported in 100 (12%) cases, the most 
      common of which were pulmonary hemorrhage (n = 20) and arrhythmia (n = 17). There 
      were 14 severe/catastrophic AEs (1.7% of cases) including three strokes and one 
      patient death. On multivariable analysis, age less than 6 months, low systemic 
      arterial saturation (< 95% in patients with biventricular [BiV] physiology, < 78% 
      in single ventricle [SV] physiology), and severely elevated mean PA pressure 
      (>/= 45 mmHg in BiV, >/= 17 mmHg in SV) were associated with SAEs. Age less than 
      1 year, hospitalization prior to catheterization, and moderate-severe RV 
      dysfunction were associated with high-level support after catheterization. 
      Serious AEs during transcatheter PV interventions in patients with PVS are 
      common, although major events such as stroke or death are uncommon. Younger 
      patients and those with abnormal hemodynamics are more likely to experience 
      serious AEs and require high-level cardiorespiratory support after 
      catheterization.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Barreto, Jessica A
AU  - Barreto JA
AUID- ORCID: 0000-0002-9434-0035
AD  - Department of Cardiology, Department of Pediatrics, Boston Children's Hospital, 
      Harvard Medical School, Boston, MA, USA. jessica.barreto@cardio.chboston.org.
FAU - Gauvreau, Kimberlee
AU  - Gauvreau K
AD  - Department of Cardiology, Department of Pediatrics, Boston Children's Hospital, 
      Harvard Medical School, Boston, MA, USA.
FAU - Porras, Diego
AU  - Porras D
AD  - Department of Cardiology, Department of Pediatrics, Boston Children's Hospital, 
      Harvard Medical School, Boston, MA, USA.
FAU - Esch, Jesse J
AU  - Esch JJ
AD  - Department of Cardiology, Department of Pediatrics, Boston Children's Hospital, 
      Harvard Medical School, Boston, MA, USA.
FAU - Maschietto, Nicola
AU  - Maschietto N
AD  - Department of Cardiology, Department of Pediatrics, Boston Children's Hospital, 
      Harvard Medical School, Boston, MA, USA.
FAU - Quinn, Brian
AU  - Quinn B
AD  - Department of Cardiology, Department of Pediatrics, Boston Children's Hospital, 
      Harvard Medical School, Boston, MA, USA.
FAU - Bergersen, Lisa
AU  - Bergersen L
AD  - Department of Cardiology, Department of Pediatrics, Boston Children's Hospital, 
      Harvard Medical School, Boston, MA, USA.
FAU - Stein, Mary
AU  - Stein M
AD  - Department of Anesthesiology, Critical Care and Pain Medicine, Division of 
      Cardiac Anesthesia, Boston Children's Hospital, Harvard Medical School, Boston, 
      MA, USA.
FAU - Callahan, Ryan
AU  - Callahan R
AD  - Division of Cardiology, Department of Pediatrics, Children's Hospital of 
      Philadelphia, University of Pennsylvania Perelman School of Medicine, 
      Philadelphia, PA, USA.
LA  - eng
PT  - Journal Article
DEP - 20230303
PL  - United States
TA  - Pediatr Cardiol
JT  - Pediatric cardiology
JID - 8003849
SB  - IM
MH  - Humans
MH  - Infant
MH  - *Pulmonary Veins/surgery
MH  - Retrospective Studies
MH  - *Stenosis, Pulmonary Vein
MH  - Constriction, Pathologic
MH  - Catheterization
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Adverse events
OT  - Catheterization
OT  - ECMO
OT  - Mechanical ventilation
OT  - Pulmonary vein stenosis
OT  - Vasoactive support
EDAT- 2023/03/04 06:00
MHDA- 2023/04/03 06:42
CRDT- 2023/03/03 23:20
PHST- 2023/01/12 00:00 [received]
PHST- 2023/02/10 00:00 [accepted]
PHST- 2023/04/03 06:42 [medline]
PHST- 2023/03/04 06:00 [pubmed]
PHST- 2023/03/03 23:20 [entrez]
AID - 10.1007/s00246-023-03129-6 [pii]
AID - 10.1007/s00246-023-03129-6 [doi]
PST - ppublish
SO  - Pediatr Cardiol. 2023 Apr;44(4):806-815. doi: 10.1007/s00246-023-03129-6. Epub 
      2023 Mar 3.