PMID- 36869310
OWN - NLM
STAT- MEDLINE
DCOM- 20230307
LR  - 20230307
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Mar 3
TI  - Predictive value of pigment epithelial detachment markers for visual acuity 
      outcomes in neovascular age-related macular degeneration.
PG  - 83
LID - 10.1186/s12886-023-02797-5 [doi]
LID - 83
AB  - BACKGROUND: To determine the predictive value of quantitative morphological 
      parameters for pigment epithelial detachment (PED) of neovascular age-related 
      macular degeneration (nAMD) patients. METHODS: One eye from each of 159 patients 
      with nAMD were studied. Polypoidal choroidal vasculopathy (PCV) group included 77 
      eyes, and non-PCV group 82. Patients received conbercept 0.05 ml (0.5 mg) in a 
      3 + ProReNata (PRN) treatment regimen. Correlations between retinal morphologic 
      parameters at baseline and best-corrected visual acuity (BCVA) gain at 3 or 
      12 months after treatment (structure-function correlations) were assessed. 
      Optical coherence tomography (OCT) scans were used to assess retinal morphologic 
      features including intraretinal cystoid fluid (IRC), subretinal fluid (SRF), PED 
      or PED type (PEDT), and vitreomacular adhesion (VMA). Greatest height (PEDH) and 
      width of PED (PEDW), and volume of PED (PEDV) at baseline were also measured. 
      RESULTS: For non-PCV group, BCVA gain from 3 or 12 months after treatment 
      was negatively correlated with PEDV at baseline (r = -0.329, -0.312, P = 0.027, 
      0.037). BCVA gain at 12 months after treatment was negatively correlated with 
      PEDW at baseline (r = -0.305, P = 0.044). For PCV group, there were no 
      correlations with PEDV, PEDH, PEDW, and PEDT in BCVA gain between baseline and 3 
      or 12 months after treatment (P > 0.05). SRF, IRC, VMA at baseline did not 
      correlate with short-term and long-term BCVA gain in patients with nAMD 
      (P > 0.05). CONCLUSION: For patients with non-PCV, PEDV at baseline was 
      negatively correlated with short-term and long-term BCVA gain, and PEDW was 
      negatively correlated with long-term BCVA gain. On the contrary, quantitative 
      morphological parameters for PED at baseline had no correlation with BCVA gain in 
      patients with PCV.
CI  - (c) 2023. The Author(s).
FAU - Shu, Yiyang
AU  - Shu Y
AD  - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, 200080, China.
AD  - National Clinical Research Center for Eye Diseases, Shanghai, China.
AD  - Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai, China.
AD  - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, 
      China.
AD  - Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, 
      Shanghai, China.
FAU - Ye, Fuxiang
AU  - Ye F
AD  - Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
FAU - Liu, Haiyun
AU  - Liu H
AD  - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, 200080, China. drliuhaiyun@126.com.
AD  - National Clinical Research Center for Eye Diseases, Shanghai, China. 
      drliuhaiyun@126.com.
AD  - Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai, China. 
      drliuhaiyun@126.com.
AD  - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, 
      China. drliuhaiyun@126.com.
AD  - Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, 
      Shanghai, China. drliuhaiyun@126.com.
FAU - Wei, Jin
AU  - Wei J
AD  - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, 200080, China.
AD  - National Clinical Research Center for Eye Diseases, Shanghai, China.
AD  - Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai, China.
AD  - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, 
      China.
AD  - Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, 
      Shanghai, China.
FAU - Sun, Xiaodong
AU  - Sun X
AD  - Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, 200080, China.
AD  - National Clinical Research Center for Eye Diseases, Shanghai, China.
AD  - Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai, China.
AD  - Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, 
      China.
AD  - Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, 
      Shanghai, China.
LA  - eng
GR  - 201409006700/Shanghai Experimental Animal Research Project of Science and 
      Technology Innovation Action Plan/
PT  - Journal Article
DEP - 20230303
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
SB  - IM
MH  - Humans
MH  - *Retinal Detachment
MH  - *Retinal Diseases
MH  - Retina
MH  - *Orbital Diseases
MH  - Polypoidal Choroidal Vasculopathy
MH  - Visual Acuity
MH  - *Macular Degeneration
PMC - PMC9983272
OTO - NOTNLM
OT  - Age-related macular degeneration
OT  - Images marker
OT  - Optical coherence tomography
OT  - Pigment epithelial detachment
OT  - Polypoidal choroidal vasculopathy
COIS- The authors declare no competing interests.
EDAT- 2023/03/04 06:00
MHDA- 2023/03/08 06:00
PMCR- 2023/03/03
CRDT- 2023/03/03 23:29
PHST- 2022/04/19 00:00 [received]
PHST- 2023/01/27 00:00 [accepted]
PHST- 2023/03/03 23:29 [entrez]
PHST- 2023/03/04 06:00 [pubmed]
PHST- 2023/03/08 06:00 [medline]
PHST- 2023/03/03 00:00 [pmc-release]
AID - 10.1186/s12886-023-02797-5 [pii]
AID - 2797 [pii]
AID - 10.1186/s12886-023-02797-5 [doi]
PST - epublish
SO  - BMC Ophthalmol. 2023 Mar 3;23(1):83. doi: 10.1186/s12886-023-02797-5.