PMID- 36870015 OWN - NLM STAT- MEDLINE DCOM- 20230728 LR - 20230729 IS - 1720-8386 (Electronic) IS - 0391-4097 (Print) IS - 0391-4097 (Linking) VI - 46 IP - 9 DP - 2023 Sep TI - Retinal sensitivity and gaze fixation evaluated by microperimetry in subjects with type 2 diabetes: two independent parameters that explore different neuronal circuits. PG - 1875-1880 LID - 10.1007/s40618-023-02046-y [doi] AB - BACKGROUND AND AIMS: Retinal sensitivity (RS) and gaze fixation (GF) assessed by retinal microperimetry are useful and complementary tools for identifying mild cognitive impairment (MCI) in patients with type 2 diabetes (T2D). The hypothesis is that RS and GF examine different neural circuits: RS depends only on the visual pathway while GF reflects white matter complex connectivity networks. The aim of the study is to shed light to this issue by examining the relationship of these two parameters with visual evoked potentials (VEP), the current gold standard to examine the visual pathway. MATERIALS AND METHODS: Consecutive T2D patients > 65 years were recruited from the outpatient clinic. Retinal microperimetry (MAIA 3rd generation) and visual evoked potentials (VEP) (Nicolet Viking ED). RS (dB), GF (BCEA63%, BCEA95%) (MAIA) and VEP (Latency P100ms, Amplitude75-100 uV) were analyzed. RESULTS: Thirty three patients (45% women, 72.1 +/- 4.6 years) were included. VEP parameters significantly correlated with RS but not with GF. CONCLUSIONS: These results confirm that RS but not GF depends on the visual pathway, reinforcing the concept that they are complementary diagnostic tools. Used together can further increase the value of microperimetry as screening test for identifying T2D population with cognitive impairment. CI - (c) 2023. The Author(s). FAU - Ortiz-Zuniga, A M AU - Ortiz-Zuniga AM AD - Department of Endocrinology and Nutrition, Hospital Universitari Vall Hebron, Pg Vall Hebron 119-129, 08035, Barcelona, Spain. AD - Institut de Recerca Vall d'Hebron, Universitat Autonoma de Barcelona (VHIR-UAB), Pg Vall Hebron 119-129, 08035, Barcelona, Spain. FAU - Rojano Toimil, A AU - Rojano Toimil A AD - Department of Endocrinology and Nutrition, Hospital Universitari Vall Hebron, Pg Vall Hebron 119-129, 08035, Barcelona, Spain. FAU - Rahnama, K AU - Rahnama K AD - Department of Clinical Neurophysiology, Hospital Universitari Vall Hebron, Pg Vall Hebron 119-129, 08035, Barcelona, Spain. FAU - Lainez, E AU - Lainez E AD - Department of Clinical Neurophysiology, Hospital Universitari Vall Hebron, Pg Vall Hebron 119-129, 08035, Barcelona, Spain. FAU - Raguer, N AU - Raguer N AD - Department of Clinical Neurophysiology, Hospital Universitari Vall Hebron, Pg Vall Hebron 119-129, 08035, Barcelona, Spain. FAU - Simo-Servat, O AU - Simo-Servat O AD - Department of Endocrinology and Nutrition, Hospital Universitari Vall Hebron, Pg Vall Hebron 119-129, 08035, Barcelona, Spain. AD - Institut de Recerca Vall d'Hebron, Universitat Autonoma de Barcelona (VHIR-UAB), Pg Vall Hebron 119-129, 08035, Barcelona, Spain. AD - CIBER de Diabetes y Enfermedades Metabolicas Asociadas, Instituto de Salud Carlos III, C/Monforte de Lemos 3-5.Pabellon 11, 28029, Madrid, Spain. FAU - Hernandez, C AU - Hernandez C AD - Department of Endocrinology and Nutrition, Hospital Universitari Vall Hebron, Pg Vall Hebron 119-129, 08035, Barcelona, Spain. AD - Institut de Recerca Vall d'Hebron, Universitat Autonoma de Barcelona (VHIR-UAB), Pg Vall Hebron 119-129, 08035, Barcelona, Spain. AD - CIBER de Diabetes y Enfermedades Metabolicas Asociadas, Instituto de Salud Carlos III, C/Monforte de Lemos 3-5.Pabellon 11, 28029, Madrid, Spain. FAU - Simo, R AU - Simo R AUID- ORCID: 0000-0003-0475-3096 AD - Department of Endocrinology and Nutrition, Hospital Universitari Vall Hebron, Pg Vall Hebron 119-129, 08035, Barcelona, Spain. rafael.simo@vhir.org. AD - Institut de Recerca Vall d'Hebron, Universitat Autonoma de Barcelona (VHIR-UAB), Pg Vall Hebron 119-129, 08035, Barcelona, Spain. rafael.simo@vhir.org. AD - CIBER de Diabetes y Enfermedades Metabolicas Asociadas, Instituto de Salud Carlos III, C/Monforte de Lemos 3-5.Pabellon 11, 28029, Madrid, Spain. rafael.simo@vhir.org. FAU - Ciudin, A AU - Ciudin A AUID- ORCID: 0000-0001-5622-0203 AD - Department of Endocrinology and Nutrition, Hospital Universitari Vall Hebron, Pg Vall Hebron 119-129, 08035, Barcelona, Spain. andreea.ciudin@vallhebron.cat. AD - Institut de Recerca Vall d'Hebron, Universitat Autonoma de Barcelona (VHIR-UAB), Pg Vall Hebron 119-129, 08035, Barcelona, Spain. andreea.ciudin@vallhebron.cat. AD - CIBER de Diabetes y Enfermedades Metabolicas Asociadas, Instituto de Salud Carlos III, C/Monforte de Lemos 3-5.Pabellon 11, 28029, Madrid, Spain. andreea.ciudin@vallhebron.cat. LA - eng GR - PI20/01703/Instituto de Salud Carlos III/ PT - Journal Article DEP - 20230304 PL - Italy TA - J Endocrinol Invest JT - Journal of endocrinological investigation JID - 7806594 SB - IM MH - Humans MH - Female MH - Male MH - *Visual Field Tests/methods MH - Visual Fields MH - *Diabetes Mellitus, Type 2/complications MH - Evoked Potentials, Visual MH - Retina PMC - PMC10371889 OTO - NOTNLM OT - Gaze fixation OT - Retinal microperimetry OT - Retinal sensitivity OT - Type 2 diabetes OT - Visual evoked potentials COIS- The authors declare that they have no conflict of interest. EDAT- 2023/03/05 06:00 MHDA- 2023/07/28 06:42 PMCR- 2023/03/04 CRDT- 2023/03/04 11:18 PHST- 2022/10/25 00:00 [received] PHST- 2023/02/19 00:00 [accepted] PHST- 2023/07/28 06:42 [medline] PHST- 2023/03/05 06:00 [pubmed] PHST- 2023/03/04 11:18 [entrez] PHST- 2023/03/04 00:00 [pmc-release] AID - 10.1007/s40618-023-02046-y [pii] AID - 2046 [pii] AID - 10.1007/s40618-023-02046-y [doi] PST - ppublish SO - J Endocrinol Invest. 2023 Sep;46(9):1875-1880. doi: 10.1007/s40618-023-02046-y. Epub 2023 Mar 4.