PMID- 36870017
OWN - NLM
STAT- MEDLINE
DCOM- 20230522
LR  - 20230522
IS  - 1865-7265 (Electronic)
IS  - 1865-7265 (Linking)
VI  - 16
IP  - 3
DP  - 2023 Jun
TI  - Immune thrombocytopenic purpura in primary biliary cholangitis and localized 
      cutaneous systemic sclerosis: case report and literature review.
PG  - 432-437
LID - 10.1007/s12328-023-01776-z [doi]
AB  - Primary biliary cholangitis (PBC) is a chronic progressive cholestatic liver 
      disease of uncertain etiology. Although PBC is frequently complicated by 
      Sjogren's syndrome and chronic thyroiditis, it can also be associated with a 
      variety of other autoimmune disorders. We herein describe a rare case of immune 
      thrombocytopenic purpura (ITP) coexistence with PBC and localized cutaneous 
      systemic sclerosis (LcSSc). A 47-year-old woman with PBC and LcSSc who was 
      positive for antiphospholipid antibody experienced a rapid decrease in platelet 
      count to 1.8 x 10(4)/microL during follow-up. After clinical findings ruled out 
      thrombocytopenia from cirrhosis, a diagnosis of ITP was made following bone 
      marrow examination. Her human leukocyte antigen (HLA) type was HLA-DPB1*05:01, 
      which has been associated with disease susceptibility to PBC and LcSSc, but not 
      to ITP. A careful review of similar reports suggested that in PBC, other collagen 
      disease complications, positive antinuclear antibody, and positive 
      antiphospholipid antibody may all support a diagnosis of ITP. Clinicians should 
      be vigilant for ITP when rapid thrombocytopenia is observed during the course of 
      PBC.
CI  - (c) 2023. Japanese Society of Gastroenterology.
FAU - Okumura, Taiki
AU  - Okumura T
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
FAU - Kimura, Takefumi
AU  - Kimura T
AUID- ORCID: 0000-0002-1481-1029
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan. 
      kimuratakefumii@yahoo.co.jp.
FAU - Hihara, Yu
AU  - Hihara Y
AD  - Department of Gastroenterology, Ina Central Hospital, Ina, Japan.
FAU - Inoue, Katsuaki
AU  - Inoue K
AD  - Department of Gastroenterology, Ina Central Hospital, Ina, Japan.
FAU - Maruyama, Atsushi
AU  - Maruyama A
AD  - Department of Gastroenterology, Ina Central Hospital, Ina, Japan.
FAU - Joshita, Satoru
AU  - Joshita S
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
FAU - Umemura, Takeji
AU  - Umemura T
AD  - Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu 
      University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20230304
PL  - Japan
TA  - Clin J Gastroenterol
JT  - Clinical journal of gastroenterology
JID - 101477246
RN  - 0 (Antibodies, Antiphospholipid)
SB  - IM
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Purpura, Thrombocytopenic, Idiopathic/complications/diagnosis
MH  - *Liver Cirrhosis, Biliary/diagnosis
MH  - *Thrombocytopenia
MH  - *Scleroderma, Systemic/complications/diagnosis
MH  - Antibodies, Antiphospholipid
MH  - *Cholangitis/complications
OTO - NOTNLM
OT  - Immune thrombocytopenic purpura (ITP)
OT  - Localized cutaneous systemic sclerosis (LcSSc)
OT  - Primary biliary cholangitis (PBC)
OT  - Systemic sclerosis (SSc)
EDAT- 2023/03/05 06:00
MHDA- 2023/05/22 06:42
CRDT- 2023/03/04 11:18
PHST- 2022/12/29 00:00 [received]
PHST- 2023/02/13 00:00 [accepted]
PHST- 2023/05/22 06:42 [medline]
PHST- 2023/03/05 06:00 [pubmed]
PHST- 2023/03/04 11:18 [entrez]
AID - 10.1007/s12328-023-01776-z [pii]
AID - 10.1007/s12328-023-01776-z [doi]
PST - ppublish
SO  - Clin J Gastroenterol. 2023 Jun;16(3):432-437. doi: 10.1007/s12328-023-01776-z. 
      Epub 2023 Mar 4.