PMID- 36872709
OWN - NLM
STAT- MEDLINE
DCOM- 20230307
LR  - 20230613
IS  - 1998-3689 (Electronic)
IS  - 0301-4738 (Print)
IS  - 0301-4738 (Linking)
VI  - 71
IP  - 3
DP  - 2023 Mar
TI  - Comparative study to evaluate retinal changes using spectral-domain optical 
      coherence tomography in diabetics without diabetic retinopathy.
PG  - 916-919
LID - 10.4103/ijo.IJO_1649_22 [doi]
AB  - PURPOSE: To elucidate changes in the neuro-sensory retina at the macula, using 
      spectral-domain optical coherence tomography (SD-OCT) in type 2 diabetics without 
      clinical signs of diabetic retinopathy, and compare with healthy subjects. 
      METHODS: This was a cross-sectional observational study, conducted at a tertiary 
      eye institute from November 2018 to March 2020. Type 2 diabetics visiting the 
      outpatient department with normal fundus (without any clinical signs of diabetic 
      retinopathy) were taken as Group 1, and healthy subjects as Group 2. Both 
      underwent recording of visual acuity, intraocular pressure (non-contact 
      tonometry), slit-lamp anterior segment examination, fundus examination using an 
      indirect ophthalmoscope, and macular SD-OCT. SPSS (Statistical Package for Social 
      Sciences) version 20 [IBM SPSS statistics (IBM corp. Armonk, NY, USA released 
      2011)] was used to perform the statistical analysis of the data entered in the 
      excel sheet. RESULTS: Our study included 440 eyes of 220 subjects, divided 
      equally into two groups. The mean age of patients with diabetes was 58.09 +/- 9.42 
      years, and of controls 57.25 +/- 8.91 years. The mean BCVA in group 1 and group 2 
      was 0.36 +/- 0.37 and 0.21 +/- 0.24 logMAR, respectively. SD-OCT showed thinning in 
      all areas in group 1 compared to group 2, but statistically significant thinning 
      was seen only in the central subfield (P = 0.0001), temporal parafoveal (P = 
      0.0001), temporal perifoveal (P = 0.0005), and nasal perifoveal areas (P = 0.023) 
      in group 1. There was a significant inter-eye difference noted between the right 
      and left eyes in nasal and inferior parafovea only in group 1 (P = 0.03). No 
      significant difference was noted between males and females. CONCLUSION: There was 
      significant macular thinning in diabetics compared with controls, which denotes 
      the occurrence of neuronal damage in these eyes before clinical evidence of 
      diabetic retinopathy.
FAU - Harwal, Niveditha
AU  - Harwal N
AD  - Department of Ophthalmology, ESIC Hospital, Peenya, Bengaluru, Karnataka, India.
FAU - Shashidhar, S
AU  - Shashidhar S
AD  - Department of Vtreo-Retina, Minto Eye Hospital, BMCRI, Bengaluru, Karnataka, 
      India.
FAU - Hithashree, H R
AU  - Hithashree HR
AD  - Department of Vtreo-Retina, Minto Eye Hospital, BMCRI, Bengaluru, Karnataka, 
      India.
FAU - Bypareddy, Ravi
AU  - Bypareddy R
AD  - Department of Vtreo-Retina, Minto Eye Hospital, BMCRI, Bengaluru, Karnataka, 
      India.
FAU - Vishwanath, B N
AU  - Vishwanath BN
AD  - Department of Vtreo-Retina, Minto Eye Hospital, BMCRI, Bengaluru, Karnataka, 
      India.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - India
TA  - Indian J Ophthalmol
JT  - Indian journal of ophthalmology
JID - 0405376
SB  - IM
MH  - Female
MH  - Male
MH  - Humans
MH  - Middle Aged
MH  - Aged
MH  - *Diabetic Retinopathy
MH  - Tomography, Optical Coherence
MH  - Cross-Sectional Studies
MH  - Retina
MH  - *Diabetes Mellitus, Type 2
PMC - PMC10229965
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - optical coherence tomography
OT  - retinal changes
COIS- None
EDAT- 2023/03/07 06:00
MHDA- 2023/03/08 06:00
PMCR- 2023/03/01
CRDT- 2023/03/06 02:29
PHST- 2023/03/06 02:29 [entrez]
PHST- 2023/03/07 06:00 [pubmed]
PHST- 2023/03/08 06:00 [medline]
PHST- 2023/03/01 00:00 [pmc-release]
AID - IndianJOphthalmol_2023_71_3_916_371054 [pii]
AID - IJO-71-916 [pii]
AID - 10.4103/ijo.IJO_1649_22 [doi]
PST - ppublish
SO  - Indian J Ophthalmol. 2023 Mar;71(3):916-919. doi: 10.4103/ijo.IJO_1649_22.