PMID- 36874325
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230307
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 2
DP  - 2023 Feb
TI  - Adalimumab-Induced Lupus Serositis: A Case Report and Review of the Literature.
PG  - e34568
LID - 10.7759/cureus.34568 [doi]
LID - e34568
AB  - Tumor necrosis factor-alpha (TNF-alpha) antagonist use is prevalent for the 
      treatment of autoimmune diseases, including psoriasis, ankylosing spondylitis, 
      and rheumatoid arthritis. Since the onset of its use over the last couple of 
      decades, there have been increasing reports of drug-induced antibodies and 
      antitumor necrosis factor-alpha-induced lupus (ATIL). Herein, we present a case 
      of pericarditis induced by tumor necrosis factor-alpha antagonist, adalimumab. A 
      61-year-old male with psoriatic arthritis treated with adalimumab injections for 
      five years presented with dyspnea, chest tightness, and three-pillow orthopnea. 
      Echocardiogram showed moderate pericardial effusion with early signs of 
      tamponade. Adalimumab was discontinued. He was started on colchicine and steroids 
      for a high suspicion of drug-induced serositis. With the increased use of tumor 
      necrosis factor-alpha antagonists, adverse reactions such as ATIL will become 
      more common. Such cases need to be reported to spread awareness of this possible 
      complication and avoid any delay in treatment and care.
CI  - Copyright (c) 2023, Lee et al.
FAU - Lee, Sandy
AU  - Lee S
AD  - Department of Rheumatology, Keck School of Medicine of the University of Southern 
      California, Los Angeles, USA.
FAU - Lafian, Anna
AU  - Lafian A
AD  - Division of Rheumatology, Department of Internal Medicine, Loma Linda University 
      School of Medicine, Loma Linda, USA.
FAU - Mahani, Tandis
AU  - Mahani T
AD  - Department of Internal Medicine, University of California, Riverside, USA.
FAU - Hojjati, Mehrnaz
AU  - Hojjati M
AD  - Division of Rheumatology, Department of Internal Medicine, Loma Linda University 
      School of Medicine, Loma Linda, USA.
LA  - eng
PT  - Case Reports
DEP - 20230202
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9981541
OTO - NOTNLM
OT  - adalimumab
OT  - arthritis
OT  - drug-induced lupus
OT  - pericardial effusion
OT  - tnf-alpha antagonist
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/03/07 06:00
MHDA- 2023/03/07 06:01
PMCR- 2023/02/02
CRDT- 2023/03/06 03:54
PHST- 2023/02/02 00:00 [accepted]
PHST- 2023/03/06 03:54 [entrez]
PHST- 2023/03/07 06:00 [pubmed]
PHST- 2023/03/07 06:01 [medline]
PHST- 2023/02/02 00:00 [pmc-release]
AID - 10.7759/cureus.34568 [doi]
PST - epublish
SO  - Cureus. 2023 Feb 2;15(2):e34568. doi: 10.7759/cureus.34568. eCollection 2023 Feb.