PMID- 36876781
OWN - NLM
STAT- MEDLINE
DCOM- 20230307
LR  - 20230307
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 299
DP  - 2023 Jan 1
TI  - Design and development of orally disintegrating films: A platform based on 
      hydroxypropyl methylcellulose and guar gum.
PG  - 120155
LID - S0144-8617(22)01060-8 [pii]
LID - 10.1016/j.carbpol.2022.120155 [doi]
AB  - From a design of experiments (DOE) performed under four independent variables, 
      with the filmogenicity conditions and shortest disintegration time as the 
      answers, a new oral disintegrating film (ODF) based on hydroxypropyl 
      methylcellulose (HPMC) and guar gum (GG) with the essential oil of Plectranthus 
      amboinicus L. (EOPA) was developed. Sixteen formulations were tested for 
      filmogenicity, homogeneity, and viability. The better selected ODF required 
      230.1 s for complete disintegration. The retention rate of the EOPA was 
      quantified using the nuclear magnetic resonance hydrogen technique (H(1) NMR), 
      which identified the presence of 0.14 % carvacrol. The scanning electron 
      microscopy showed a smooth and homogeneous surface with the presence of small 
      white dots. Through the disk diffusion test, the EOPA was able to inhibit the 
      growth of clinical strains of the Candida genus and gram-positive and 
      gram-negative bacterial strains. This work opens new perspectives for the 
      development of antimicrobial ODFS used in clinical practice.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Carvalho, Ana Flavia Freitas de
AU  - Carvalho AFF
AD  - Laboratory of Organic Chemistry, Federal University of the Sao Francisco Valley, 
      Petrolina, Brazil; Center for Studies and Research in Biomaterials and 
      Nanotechnology, Federal University of the Sao Francisco Valley, Petrolina, 
      Brazil. Electronic address: anaflaviac04@gmail.com.
FAU - Caldeira, Vanessa Ferreira
AU  - Caldeira VF
AD  - Laboratory of Organic Chemistry, Federal University of the Sao Francisco Valley, 
      Petrolina, Brazil.
FAU - Oliveira, Ana Paula
AU  - Oliveira AP
AD  - Federal Institute Sertao Pernambucano, campus Petrolina, Brazil.
FAU - Gonsalves, Joyce Kelly Marinheiro da Cunha
AU  - Gonsalves JKMDC
AD  - Center for Studies and Research in Biomaterials and Nanotechnology, Federal 
      University of the Sao Francisco Valley, Petrolina, Brazil.
FAU - Araujo, Edigenia Cavalcante da Cruz
AU  - Araujo ECDC
AD  - Laboratory of Organic Chemistry, Federal University of the Sao Francisco Valley, 
      Petrolina, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20220926
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - E89I1637KE (guar gum)
RN  - 3NXW29V3WO (Hypromellose Derivatives)
RN  - 0 (Galactans)
RN  - 0 (Mannans)
SB  - IM
MH  - Hypromellose Derivatives
MH  - *Galactans
MH  - *Mannans
MH  - Candida
OTO - NOTNLM
OT  - Candida
OT  - Carvacrol
OT  - Essential oil
OT  - Plectranthus amboinicus L.
OT  - Quantitative nuclear magnetic resonance
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/03/07 06:00
MHDA- 2023/03/08 06:00
CRDT- 2023/03/06 06:55
PHST- 2022/07/08 00:00 [received]
PHST- 2022/09/01 00:00 [revised]
PHST- 2022/09/22 00:00 [accepted]
PHST- 2023/03/06 06:55 [entrez]
PHST- 2023/03/07 06:00 [pubmed]
PHST- 2023/03/08 06:00 [medline]
AID - S0144-8617(22)01060-8 [pii]
AID - 10.1016/j.carbpol.2022.120155 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2023 Jan 1;299:120155. doi: 10.1016/j.carbpol.2022.120155. Epub 
      2022 Sep 26.