PMID- 36876887
OWN - NLM
STAT- MEDLINE
DCOM- 20230330
LR  - 20230330
IS  - 1532-4117 (Electronic)
IS  - 1093-4529 (Linking)
VI  - 58
IP  - 4
DP  - 2023
TI  - Heavy metals and inflammatory, oxidative/antioxidant and DNA damage biomarkers 
      among people living with HIV/AIDS (PLWHA) in Niger Delta, Nigeria.
PG  - 295-313
LID - 10.1080/10934529.2023.2185004 [doi]
AB  - This study evaluated the association of heavy metals (HMs) and effect biomarkers 
      (inflammation, oxidative stress/antioxidant capacity and DNA damage) among people 
      living with HIV/AIDS (PHWHA) in Niger Delta area, Nigeria. Blood levels of lead 
      (BPb), cadmium (BCd), copper (BCu), zinc (BZn), iron (BFe), C-reactive protein 
      (CRP), Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF-alpha), Interferon-gamma 
      (IFN-gamma), Malondialdehyde (MDA), Glutathione (GSH) and 8-hydroxy-2-deoxyguanosine 
      (8-OHdG) were determined in a total of 185 participants, 104 HIV-positive and 81 
      HIV-negative sampled in both Niger Delta and non-Niger Delta regions. BCd 
      (p < 0.001) and BPb (p = 0.139) were higher in HIV-positive subjects compared to 
      HIV-negative controls; on the contrary, BCu, BZn and BFe levels were lower 
      (p < 0.001) in HIV-positive subjects compared to HIV-negative controls. The Niger 
      Delta population had higher levels of heavy metals (p < 0.01) compared to 
      non-Niger Delta residents. CRP and 8-OHdG were higher (p < 0.001) in HIV-positive 
      than in HIV-negative subjects and in Niger-Delta than in non-Niger Delta 
      residents. BCu had significant positive dose-response relationship with CRP 
      (61.9%, p = 0.063) and GSH (1.64%, p = 0.035) levels in HIV-positive subjects, 
      and negative response with MDA levels (26.6%, p < 0.001). Periodic assessment of 
      HMs levels among PLWHA is recommended.
FAU - Folorunso, Opeyemi M
AU  - Folorunso OM
AD  - African Centre of Excellence for Public Health and Toxicological Research 
      (ACE-PUTOR), University of Port Harcourt, PMB, Port Harcourt, Rivers State, 
      Nigeria.
FAU - Bocca, Beatrice
AU  - Bocca B
AD  - Department of Environment and Health, Istituto Superiore di Sanita, Rome, Italy.
FAU - Ruggieri, Flavia
AU  - Ruggieri F
AD  - Department of Environment and Health, Istituto Superiore di Sanita, Rome, Italy.
FAU - Frazzoli, Chiara
AU  - Frazzoli C
AD  - Department for Cardiovascular, Endocrine-Metabolic Diseas, and Aging, Istituto 
      Superiore di Sanita, Rome, Italy.
FAU - Chijioke-Nwauche, Ifeyinwa
AU  - Chijioke-Nwauche I
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, University of Port 
      Harcourt, Port Harcourt, Rivers State, Nigeria.
FAU - Orisakwe, Orish E
AU  - Orisakwe OE
AUID- ORCID: 0000-0002-5806-9858
AD  - African Centre of Excellence for Public Health and Toxicological Research 
      (ACE-PUTOR), University of Port Harcourt, PMB, Port Harcourt, Rivers State, 
      Nigeria.
AD  - Department of Experimental Pharmacology & Toxicology, Faculty of Pharmacy, 
      University of Port Harcourt, Port Harcourt, Rivers State, Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20230306
PL  - England
TA  - J Environ Sci Health A Tox Hazard Subst Environ Eng
JT  - Journal of environmental science and health. Part A, Toxic/hazardous substances & 
      environmental engineering
JID - 9812551
RN  - 0 (Antioxidants)
RN  - 0 (Metals, Heavy)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Antioxidants
MH  - Nigeria/epidemiology
MH  - *Acquired Immunodeficiency Syndrome
MH  - *Metals, Heavy/analysis
MH  - Oxidative Stress
MH  - Biomarkers
OTO - NOTNLM
OT  - HIV-negative
OT  - HIV-positive
OT  - Toxic metals
OT  - biomarkers of effect
OT  - biomarkers of exposure
OT  - dose response
OT  - environmental pollution
OT  - essential metals
OT  - non-communicable diseases
OT  - oil and gas exploration
EDAT- 2023/03/07 06:00
MHDA- 2023/03/30 06:11
CRDT- 2023/03/06 07:32
PHST- 2023/03/30 06:11 [medline]
PHST- 2023/03/07 06:00 [pubmed]
PHST- 2023/03/06 07:32 [entrez]
AID - 10.1080/10934529.2023.2185004 [doi]
PST - ppublish
SO  - J Environ Sci Health A Tox Hazard Subst Environ Eng. 2023;58(4):295-313. doi: 
      10.1080/10934529.2023.2185004. Epub 2023 Mar 6.