PMID- 36880642
OWN - NLM
STAT- MEDLINE
DCOM- 20230508
LR  - 20230508
IS  - 1099-1654 (Electronic)
IS  - 1052-9276 (Linking)
VI  - 33
IP  - 3
DP  - 2023 May
TI  - Reactivation of herpesviruses during COVID-19: A systematic review and 
      meta-analysis.
PG  - e2437
LID - 10.1002/rmv.2437 [doi]
AB  - To provide a comprehensive systematic review and meta-analysis regarding the 
      cumulative incidence (incidence proportion) of human herpesvirus (HHV) 
      reactivation among patients with coronavirus disease 2019 (COVID-19), we searched 
      PubMed/MEDLINE, Web of Science, and EMBASE up to 25 September 2022, with no 
      language restrictions. All interventional and observational studies enrolling 
      patients with confirmed COVID-19 and providing data regarding HHV reactivation 
      were included. The random-effects model was used in the meta-analyses. We 
      included information from 32 studies. HHV reactivation was considered a positive 
      polymerase chain reaction result taken at the time of COVID-19 infection. Most of 
      the included patients were severe COVID-19 cases. The pooled cumulative incidence 
      estimate was 38% (95% Confidence Intervals [CI], 28%-50%, I(2)  = 86%) for herpes 
      simplex virus (HSV), 19% (95% CI, 13%-28%, I(2)  = 87%) for cytomegalovirus 
      (CMV), 45% (95% CI, 28%-63%, I(2)  = 96%) for Epstein-Barr virus (EBV), 18% (95% 
      CI, 8%-35%) for human herpesvirus 6 (HHV-6), 44% (95% CI, 32%-56%) for human 
      herpesvirus 7 (HHV-7), and 19% (95% CI, 14%-26%) for human herpesvirus 8 (HHV-8). 
      There was no evidence of funnel plot asymmetry based on visual inspection and 
      Egger's regression test for the results of HSV (p = 0.84), CMV (p = 0.82), and 
      EBV (p = 0.27) reactivation. In conclusion, the identification of HHV 
      reactivation in severe COVID-19 patients is helpful in the management of patients 
      as well as the prevention of complications. Further research is required to 
      elucidate the interaction between HHVs and COVID-19. Systematic review 
      registration: PROSPERO CRD42022321973.
CI  - (c) 2023 John Wiley & Sons Ltd.
FAU - Shafiee, Arman
AU  - Shafiee A
AD  - Clinical Research Development Unit, Alborz University of Medical Sciences, Karaj, 
      Iran.
AD  - Student Research Committee, School of Medicine, Alborz University of Medical 
      Sciences, Karaj, Iran.
FAU - Teymouri Athar, Mohammad Mobin
AU  - Teymouri Athar MM
AUID- ORCID: 0000-0002-1933-9659
AD  - School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Amini, Mohammad Javad
AU  - Amini MJ
AD  - Student Research Committee, School of Medicine, Alborz University of Medical 
      Sciences, Karaj, Iran.
FAU - Hajishah, Hamed
AU  - Hajishah H
AD  - Student Research Committee, Tehran Medical Sciences Branch, Islamic Azad 
      University, Tehran, Iran.
FAU - Siahvoshi, Sepehr
AU  - Siahvoshi S
AD  - Dental Materials Research Center, Dental School, Islamic Azad University of 
      Medical Sciences, Tehran, Iran.
FAU - Jalali, Mehrsa
AU  - Jalali M
AD  - Student Research Committee, School of Medicine, Alborz University of Medical 
      Sciences, Karaj, Iran.
FAU - Jahanbakhshi, Bahar
AU  - Jahanbakhshi B
AD  - Student Research Committee, School of Medicine, Alborz University of Medical 
      Sciences, Karaj, Iran.
FAU - Mozhgani, Sayed-Hamidreza
AU  - Mozhgani SH
AUID- ORCID: 0000-0003-4570-2252
AD  - Department of Microbiology, School of Medicine, Alborz University of Medical 
      Sciences, Karaj, Iran.
AD  - Non-communicable Diseases Research Center, Alborz University of Medical Sciences, 
      Karaj, Iran.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20230307
PL  - England
TA  - Rev Med Virol
JT  - Reviews in medical virology
JID - 9112448
SB  - IM
MH  - Humans
MH  - *Herpesviridae Infections/complications/epidemiology
MH  - *Epstein-Barr Virus Infections/complications
MH  - Herpesvirus 4, Human/physiology
MH  - *COVID-19/complications
MH  - *Herpesviridae
MH  - Simplexvirus
MH  - Cytomegalovirus/physiology
MH  - *Herpesvirus 6, Human/genetics
MH  - *Cytomegalovirus Infections
OTO - NOTNLM
OT  - COVID-19
OT  - SARS-CoV-2
OT  - human herpesviruses
EDAT- 2023/03/08 06:00
MHDA- 2023/05/08 10:17
CRDT- 2023/03/07 07:53
PHST- 2023/02/10 00:00 [revised]
PHST- 2022/12/29 00:00 [received]
PHST- 2023/02/15 00:00 [accepted]
PHST- 2023/05/08 10:17 [medline]
PHST- 2023/03/08 06:00 [pubmed]
PHST- 2023/03/07 07:53 [entrez]
AID - 10.1002/rmv.2437 [doi]
PST - ppublish
SO  - Rev Med Virol. 2023 May;33(3):e2437. doi: 10.1002/rmv.2437. Epub 2023 Mar 7.