PMID- 36881377 OWN - NLM STAT- MEDLINE DCOM- 20230623 LR - 20230623 IS - 1865-3774 (Electronic) IS - 0925-5710 (Linking) VI - 118 IP - 1 DP - 2023 Jul TI - Human leukocyte antigen 7/8-matched unrelated bone marrow transplantation using anti-thymocyte globulin in children. PG - 125-130 LID - 10.1007/s12185-023-03571-5 [doi] AB - Human leukocyte antigen (HLA) mismatched unrelated donor transplantation is associated with an increased risk of graft-versus-host disease, graft failure, and infection, which increases post-transplant morbidity and mortality. In this single-center retrospective study, outcomes were evaluated in 30 consecutive children who underwent bone marrow transplantation (BMT) from HLA 1 allele-mismatched (HLA 7/8-matched) unrelated donors with rabbit anti-thymocyte globulin (rATG) as graft-versus-host disease (GVHD) prophylaxis. The 3-year overall survival (OS), event-free survival (EFS), and GVHD-relapse-free survival rates were 91.7% (95% CI 70.5%-91.9%), 88.3% (95% CI 67.5%-96.1%), and 73.9% (95% CI 52.4%-86.8%), respectively. Grade II-IV and III-IV acute GVHD occurred in 10 (33%) and 2 (7.0%) patients, respectively. The 3-year cumulative incidence of chronic GVHD was 7.8%. No fatal viral infections occurred. The study results show the feasibility of HLA 7/8-matched unrelated BMT with ATG to achieve favorable outcomes and acceptable GVHD, especially for patients who lack a fully matched donor. CI - (c) 2023. Japanese Society of Hematology. FAU - Hamada, Motoharu AU - Hamada M AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Muramatsu, Hideki AU - Muramatsu H AUID- ORCID: 0000-0002-8801-0021 AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. hideki-muramatsu@med.nagoya-u.ac.jp. FAU - Torii, Yuka AU - Torii Y AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Suzuki, Kyogo AU - Suzuki K AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Narita, Atsushi AU - Narita A AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Yoshida, Taro AU - Yoshida T AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Imaya, Masayuki AU - Imaya M AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Yamamori, Ayako AU - Yamamori A AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Wakamatsu, Manabu AU - Wakamatsu M AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Miwata, Shunsuke AU - Miwata S AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Narita, Kotaro AU - Narita K AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Kataoka, Shinsuke AU - Kataoka S AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Kawashima, Nozomu AU - Kawashima N AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Taniguchi, Rieko AU - Taniguchi R AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Nishikawa, Eri AU - Nishikawa E AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Nishio, Nobuhiro AU - Nishio N AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. AD - Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan. FAU - Ito, Yoshinori AU - Ito Y AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Kojima, Seiji AU - Kojima S AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. FAU - Takahashi, Yoshiyuki AU - Takahashi Y AD - Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, Aichi, 466-8550, Japan. ytakaha@med.nagoya-u.ac.jp. LA - eng PT - Journal Article DEP - 20230307 PL - Japan TA - Int J Hematol JT - International journal of hematology JID - 9111627 RN - 0 (Antilymphocyte Serum) RN - 0 (HLA Antigens) RN - 0 (Histocompatibility Antigens Class II) SB - IM MH - Humans MH - Child MH - Bone Marrow Transplantation/adverse effects MH - Antilymphocyte Serum/therapeutic use MH - Retrospective Studies MH - Transplantation, Homologous/adverse effects MH - *Graft vs Host Disease/etiology/prevention & control MH - HLA Antigens/genetics MH - Unrelated Donors MH - Histocompatibility Antigens Class II MH - *Hematopoietic Stem Cell Transplantation/adverse effects OTO - NOTNLM OT - ATG OT - BMT OT - GVHD prophylaxis OT - Pediatric OT - Unrelated donor EDAT- 2023/03/08 06:00 MHDA- 2023/06/23 06:42 CRDT- 2023/03/07 11:24 PHST- 2022/10/03 00:00 [received] PHST- 2023/02/19 00:00 [accepted] PHST- 2023/02/18 00:00 [revised] PHST- 2023/06/23 06:42 [medline] PHST- 2023/03/08 06:00 [pubmed] PHST- 2023/03/07 11:24 [entrez] AID - 10.1007/s12185-023-03571-5 [pii] AID - 10.1007/s12185-023-03571-5 [doi] PST - ppublish SO - Int J Hematol. 2023 Jul;118(1):125-130. doi: 10.1007/s12185-023-03571-5. Epub 2023 Mar 7.