PMID- 36881752
OWN - NLM
STAT- MEDLINE
DCOM- 20230309
LR  - 20231213
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Linking)
VI  - 34
IP  - 5
DP  - 2023 Mar 22
TI  - Disinhibition of short-latency but not long-latency afferent inhibition of the 
      lower limb during upper-limb muscle contraction.
PG  - 280-286
LID - 10.1097/WNR.0000000000001889 [doi]
AB  - Research has demonstrated that motor and sensory functions of the lower limbs can 
      be modulated by upper-limb muscle contractions. However, whether sensorimotor 
      integration of the lower limb can be modulated by upper-limb muscle contractions 
      is still unknown. [AQ: NR Original articles do not require structured abstracts. 
      Hence, abstract subsections have been deleted. Please check.]Human sensorimotor 
      integration has been studied using short- or long-latency afferent inhibition 
      (SAI or LAI, respectively), which refers to inhibition of motor-evoked potentials 
      (MEPs) elicited via transcranial magnetic stimulation by preceding peripheral 
      sensory stimulation. In the present study, we aimed to investigate whether 
      upper-limb muscle contractions could modulate the sensorimotor integration of the 
      lower limbs by examining SAI and LAI. Soleus muscle MEPs following electrical 
      tibial nerve stimulation (TSTN) during rest or voluntary wrist flexion were 
      recorded at inter-stimulus intervals (ISIs) of 30 (i.e. SAI), 100, and 200 ms 
      (i.e. LAI). The soleus Hoffman reflex following TSTN was also measured to 
      identify whether MEP modulation occurred at the cortical or the spinal level. 
      Results showed that lower-limb SAI, but not LAI, was disinhibited during 
      voluntary wrist flexion. Furthermore, the soleus Hoffman reflex following TSTN 
      during voluntary wrist flexion was unchanged when compared with that during the 
      resting state at any ISI. Our findings suggest that upper-limb muscle 
      contractions modulate sensorimotor integration of the lower limbs and that 
      disinhibition of lower-limb SAI during upper-limb muscle contractions is 
      cortically based.
CI  - Copyright (c) 2023 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Kato, Tatsuya
AU  - Kato T
AUID- ORCID: 0000-0001-9484-0526
AD  - Department of Life Sciences, Graduate School of Arts and Sciences, The University 
      of Tokyo.
AD  - Japan Society for the Promotion of Science, Tokyo.
FAU - Sasaki, Atsushi
AU  - Sasaki A
AUID- ORCID: 0000-0001-9484-0526
AD  - Department of Life Sciences, Graduate School of Arts and Sciences, The University 
      of Tokyo.
AD  - Japan Society for the Promotion of Science, Tokyo.
FAU - Nakazawa, Kimitaka
AU  - Nakazawa K
AUID- ORCID: 0000-0001-9484-0526
AD  - Department of Life Sciences, Graduate School of Arts and Sciences, The University 
      of Tokyo.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230301
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
SB  - IM
MH  - Humans
MH  - *Upper Extremity
MH  - *Wrist
MH  - Lower Extremity
MH  - Sensation
MH  - Muscle Contraction
EDAT- 2023/03/08 06:00
MHDA- 2023/03/10 06:00
CRDT- 2023/03/07 15:22
PHST- 2023/03/07 15:22 [entrez]
PHST- 2023/03/08 06:00 [pubmed]
PHST- 2023/03/10 06:00 [medline]
AID - 00001756-202303020-00005 [pii]
AID - 10.1097/WNR.0000000000001889 [doi]
PST - ppublish
SO  - Neuroreport. 2023 Mar 22;34(5):280-286. doi: 10.1097/WNR.0000000000001889. Epub 
      2023 Mar 1.