PMID- 36882778
OWN - NLM
STAT- MEDLINE
DCOM- 20230309
LR  - 20230314
IS  - 1755-8794 (Electronic)
IS  - 1755-8794 (Linking)
VI  - 16
IP  - 1
DP  - 2023 Mar 7
TI  - Association of gastric inhibitory polypeptide receptor (GIPR) gene polymorphism 
      with type 2 diabetes mellitus in iranian patients.
PG  - 44
LID - 10.1186/s12920-023-01477-z [doi]
LID - 44
AB  - INTRODUCTION: Gastric inhibitory polypeptide receptor (GIPR) encodes a G-protein 
      coupled receptor for gastric inhibitory polypeptide (GIP), which was demonstrated 
      to stimulate insulin secretion. Relation of GIPR gene variation to impaired 
      insulin response has been suggested in previous studies. However, little 
      information is available regarding GIPR polymorphisms and type 2 diabetes 
      mellitus (T2DM). Hence, the aim of the study was to investigate single nucleotide 
      polymorphisms (SNPs) in the promoter and coding regions of GIPR in Iranian T2DM 
      patients. MATERIALS AND METHODS: Two hundred subjects including 100 healthy and 
      100 T2DM patients were recruited in the study. Genotypes and allele frequency of 
      rs34125392, rs4380143 and rs1800437 in the promoter, 5' UTR and coding region of 
      GIPR were investigated by RFLP-PCR and Nested-PCR. RESULTS: Our finding indicated 
      that rs34125392 genotype distribution was statistically different between T2DM 
      and healthy groups (P = 0.043). In addition, distribution of T/- + -/- versus TT 
      was significantly different between the both groups (P = 0.021). Moreover, 
      rs34125392 T/- genotype increased the risk of T2DM (OR = 2.68, 
      95%CI = 1.203-5.653, P = 0.015). However, allele frequency and genotype 
      distributions of rs4380143 and rs1800437 were not statistically different between 
      the groups (P > 0.05). Multivariate analysis showed that the tested polymorphisms 
      had no effect on biochemical variables. CONCLUSION: We concluded that GIPR gene 
      polymorphism is associated with T2DM. In addition; rs34125392 heterozygote 
      genotype may increase the risk of T2DM. More studies with large sample size in 
      other populations are recommended to show the ethnical relation of these 
      polymorphisms to T2DM.
CI  - (c) 2023. The Author(s).
FAU - Erfanian, Saiedeh
AU  - Erfanian S
AD  - Department of Biochemistry and Nutrition, Jahrom University of Medical Sciences, 
      Jahrom, Iran.
AD  - Department of Advanced Medical Sciences and Technologies, Jahrom University of 
      Medical Sciences, Jahrom, Iran.
FAU - Mir, Hamed
AU  - Mir H
AD  - Department of Biochemistry and Nutrition, Jahrom University of Medical Sciences, 
      Jahrom, Iran.
FAU - Abdoli, Amir
AU  - Abdoli A
AD  - Department of Parasitology, School of medicine, Jahrom University of Medical 
      Sciences, Jahrom, Iran.
FAU - Roustazadeh, Abazar
AU  - Roustazadeh A
AD  - Department of Biochemistry and Nutrition, Jahrom University of Medical Sciences, 
      Jahrom, Iran. Roustazadeh@yahoo.com.
AD  - Department of Advanced Medical Sciences and Technologies, Jahrom University of 
      Medical Sciences, Jahrom, Iran. Roustazadeh@yahoo.com.
AD  - Research Center for Non-Communicable Diseases, Jahrom University of Medical 
      Sciences, Jahrom, Iran. Roustazadeh@yahoo.com.
AD  - Ostad motahhari Blvd, Jahrom University of Medical Sciences, 74148-46199, Jahrom, 
      Iran. Roustazadeh@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230307
PL  - England
TA  - BMC Med Genomics
JT  - BMC medical genomics
JID - 101319628
RN  - D6H00MV7K8 (gastric inhibitory polypeptide receptor)
RN  - 0 (Receptors, Gastrointestinal Hormone)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - Genotype
MH  - Iran
MH  - Polymorphism, Single Nucleotide
MH  - *Receptors, Gastrointestinal Hormone/genetics
PMC - PMC9990261
OTO - NOTNLM
OT  - Gastric inhibitory polypeptide receptor
OT  - Middle East
OT  - Polymorphism
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no competing interests.
EDAT- 2023/03/08 06:00
MHDA- 2023/03/10 06:00
PMCR- 2023/03/07
CRDT- 2023/03/07 23:34
PHST- 2022/09/19 00:00 [received]
PHST- 2023/03/03 00:00 [accepted]
PHST- 2023/03/07 23:34 [entrez]
PHST- 2023/03/08 06:00 [pubmed]
PHST- 2023/03/10 06:00 [medline]
PHST- 2023/03/07 00:00 [pmc-release]
AID - 10.1186/s12920-023-01477-z [pii]
AID - 1477 [pii]
AID - 10.1186/s12920-023-01477-z [doi]
PST - epublish
SO  - BMC Med Genomics. 2023 Mar 7;16(1):44. doi: 10.1186/s12920-023-01477-z.