PMID- 36884125
OWN - NLM
STAT- MEDLINE
DCOM- 20231102
LR  - 20231102
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 201
IP  - 12
DP  - 2023 Dec
TI  - Effects of Treadmill Exercise on Liver Apoptosis in Fluoride-Exposed Mice.
PG  - 5734-5746
LID - 10.1007/s12011-023-03619-x [doi]
AB  - Hepatotoxicity induced by excessive fluoride (F) exposure has been extensively 
      studied in both humans and animals. Chronic fluorosis can result in liver 
      apoptosis. Meanwhile, moderate exercise alleviates apoptosis caused by 
      pathological factors. However, the effect of moderate exercise on F-induced liver 
      apoptosis remains unclear. In this research, sixty-four three-week-old Institute 
      of Cancer Research (ICR) mice, half male and half female, were randomly divided 
      into four groups: control group (distilled water); exercise group (distilled 
      water and treadmill exercise); F group [100 mg/L sodium fluoride (NaF)]; and 
      exercise plus F group (100 mg/L NaF and treadmill exercise). The liver tissues of 
      mice were taken at 3 months and 6 months, respectively. Hematoxylin-eosin (HE) 
      staining and situ terminal deoxynucleotidyl transferase-mediated dUTP nick end 
      labeling (TUNEL) results showed that nuclear condensation and apoptotic 
      hepatocytes occurred in the F group. However, this phenomenon could be reversed 
      with the intervention of treadmill exercise. The results of QRT-PCR and western 
      blot displayed NaF- induced apoptosis via tumor necrosis factor recpter 1 (TNFR1) 
      signaling pathway, while treadmill exercise could restore the molecular changes 
      caused by excessive NaF exposure.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Liu, Ke
AU  - Liu K
AUID- ORCID: 0000-0002-6168-7577
AD  - Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary 
      Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural 
      University, Taigu, Jinzhong, 030801, Shanxi, China.
FAU - Chai, Lei
AU  - Chai L
AD  - Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary 
      Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural 
      University, Taigu, Jinzhong, 030801, Shanxi, China.
FAU - Zhao, Taotao
AU  - Zhao T
AD  - Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary 
      Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural 
      University, Taigu, Jinzhong, 030801, Shanxi, China.
FAU - Zhang, Shaosan
AU  - Zhang S
AD  - Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary 
      Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural 
      University, Taigu, Jinzhong, 030801, Shanxi, China.
FAU - Wang, Jixiang
AU  - Wang J
AD  - Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary 
      Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural 
      University, Taigu, Jinzhong, 030801, Shanxi, China.
FAU - Yu, Yanghuan
AU  - Yu Y
AD  - Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary 
      Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural 
      University, Taigu, Jinzhong, 030801, Shanxi, China.
FAU - Niu, Ruiyan
AU  - Niu R
AD  - Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary 
      Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural 
      University, Taigu, Jinzhong, 030801, Shanxi, China.
FAU - Sun, Zilong
AU  - Sun Z
AUID- ORCID: 0000-0003-4907-7271
AD  - Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary 
      Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural 
      University, Taigu, Jinzhong, 030801, Shanxi, China. sunzilong2000@outlook.com.
LA  - eng
GR  - 2021Y350/Shanxi Province Innovation Project for Graduates Students/
GR  - HGKY2019042/Shanxi Scholarship Council of China/
GR  - DY-M007/Scientific Research Innovation Project in College of Veterinary Medicne 
      of Shanxi Agricultural University/
PT  - Journal Article
DEP - 20230308
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - Q80VPU408O (Fluorides)
RN  - 8ZYQ1474W7 (Sodium Fluoride)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Male
MH  - Female
MH  - Animals
MH  - *Fluorides/toxicity/metabolism
MH  - *Liver/metabolism
MH  - Apoptosis
MH  - Sodium Fluoride/toxicity
MH  - Water/metabolism
OTO - NOTNLM
OT  - Apoptosis
OT  - Fluorosis
OT  - Mice
OT  - TNFR1
OT  - Treadmill exercise
EDAT- 2023/03/09 06:00
MHDA- 2023/11/02 12:44
CRDT- 2023/03/08 11:17
PHST- 2022/12/20 00:00 [received]
PHST- 2023/02/28 00:00 [accepted]
PHST- 2023/11/02 12:44 [medline]
PHST- 2023/03/09 06:00 [pubmed]
PHST- 2023/03/08 11:17 [entrez]
AID - 10.1007/s12011-023-03619-x [pii]
AID - 10.1007/s12011-023-03619-x [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2023 Dec;201(12):5734-5746. doi: 10.1007/s12011-023-03619-x. 
      Epub 2023 Mar 8.