PMID- 36889182
OWN - NLM
STAT- MEDLINE
DCOM- 20230418
LR  - 20230421
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 254
DP  - 2023 Apr
TI  - Functional dysconnectivity of anterior cingulate subregions in schizophrenia and 
      psychotic and nonpsychotic bipolar disorder.
PG  - 155-162
LID - S0920-9964(23)00075-0 [pii]
LID - 10.1016/j.schres.2023.02.023 [doi]
AB  - Aberrant resting-state functional connectivity (FC) of anterior cingulate cortex 
      (ACC) has been implicated in the pathophysiology of schizophrenia and bipolar 
      disorder (BP). This study investigated the subregional FC of ACC across 
      schizophrenia and psychotic (PBP) and nonpsychotic BP (NPBP) and the relationship 
      between brain functional alterations and clinical manifestations. A total of 174 
      first-episode medication-naive patients with schizophrenia (FES), 80 patients 
      with PBP, 77 patients with NPBP and 173 demographically matched healthy controls 
      (HCs) underwent resting-state functional magnetic resonance imaging. Brain-wide 
      FC of ACC subregions was computed for each individual, and compared between the 
      groups. General intelligence was evaluated using the short version of the 
      Wechsler Adult Intelligence Scale. Relationships between FC and various clinical 
      and cognitive variables were estimated using the skipped correlation. The FES, 
      PBP and NPBP groups showed differing connectivity patterns in the left caudal, 
      dorsal and perigenual ACC. Transdiagnostic dysconnectivity was found in the 
      subregional ACC associated with cortical, limbic, striatal and cerebellar 
      regions. Disorder-specific dysconnectivity in FES was identified between the left 
      perigenual ACC and bilateral orbitofrontal cortex, and the left caudal ACC 
      coupling with the default mode network (DMN) and visual processing region was 
      correlated with psychotic symptoms. In the PBP group, FC between the left dorsal 
      ACC and the right caudate was correlated with psychotic symptoms, and FC 
      connected with the DMN was associated with affective symptoms. The current 
      findings confirmed that subregional ACC dysconnectivity could be a key 
      transdiagnostic feature and associated with differing clinical symptomology 
      across schizophrenia and PBP.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Liang, Sugai
AU  - Liang S
AD  - Affiliated Mental Health Centre & Hangzhou Seventh People's Hospital, Zhejiang 
      University School of Medicine, Hangzhou 310013, Zhejiang, China; Mental Health 
      Centre & West China Brain Research Centre & Psychiatric Laboratory, State Key 
      Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 
      610041, Sichuan, China.
FAU - Cao, Bo
AU  - Cao B
AD  - Department of Psychiatry, University of Alberta, Edmonton T6G 2B7, AB, Canada.
FAU - Deng, Wei
AU  - Deng W
AD  - Mental Health Centre & West China Brain Research Centre & Psychiatric Laboratory, 
      State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 
      Chengdu 610041, Sichuan, China.
FAU - Kong, Xiangzhen
AU  - Kong X
AD  - Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou 
      310058, Zhejiang, China.
FAU - Zhao, Liansheng
AU  - Zhao L
AD  - Mental Health Centre & West China Brain Research Centre & Psychiatric Laboratory, 
      State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 
      Chengdu 610041, Sichuan, China.
FAU - Jin, Yan
AU  - Jin Y
AD  - Affiliated Mental Health Centre & Hangzhou Seventh People's Hospital, Zhejiang 
      University School of Medicine, Hangzhou 310013, Zhejiang, China.
FAU - Ma, Xiaohong
AU  - Ma X
AD  - Mental Health Centre & West China Brain Research Centre & Psychiatric Laboratory, 
      State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 
      Chengdu 610041, Sichuan, China.
FAU - Wang, Yingcheng
AU  - Wang Y
AD  - Mental Health Centre & West China Brain Research Centre & Psychiatric Laboratory, 
      State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 
      Chengdu 610041, Sichuan, China.
FAU - Li, Xiaojing
AU  - Li X
AD  - Mental Health Centre & West China Brain Research Centre & Psychiatric Laboratory, 
      State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 
      Chengdu 610041, Sichuan, China.
FAU - Wang, Qiang
AU  - Wang Q
AD  - Mental Health Centre & West China Brain Research Centre & Psychiatric Laboratory, 
      State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 
      Chengdu 610041, Sichuan, China.
FAU - Guo, Wanjun
AU  - Guo W
AD  - Mental Health Centre & West China Brain Research Centre & Psychiatric Laboratory, 
      State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 
      Chengdu 610041, Sichuan, China.
FAU - Du, Xiangdong
AU  - Du X
AD  - Suzhou Psychiatry Hospital, Affiliated Guangji Hospital of Soochow University, 
      Suzhou 215137, Jiangsu, China.
FAU - Sham, Pak C
AU  - Sham PC
AD  - State Key Laboratory of Brain and Cognitive Sciences, Centre for Genomic 
      Sciences, & Department of Psychiatry, Li Ka Shing Faculty of Medicine, The 
      University of Hong Kong, Pokfulam 999077, Hong Kong, China.
FAU - Greenshaw, Andrew J
AU  - Greenshaw AJ
AD  - Department of Psychiatry, University of Alberta, Edmonton T6G 2B7, AB, Canada.
FAU - Li, Tao
AU  - Li T
AD  - Affiliated Mental Health Centre & Hangzhou Seventh People's Hospital, Zhejiang 
      University School of Medicine, Hangzhou 310013, Zhejiang, China; Mental Health 
      Centre & West China Brain Research Centre & Psychiatric Laboratory, State Key 
      Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 
      610041, Sichuan, China; Guangdong-Hong Kong-Macao Greater Bay Area Center for 
      Brain Science and Brain-Inspired Intelligence, China. Electronic address: 
      litaozjusc@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230307
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Schizophrenia/diagnostic imaging
MH  - *Bipolar Disorder/diagnostic imaging
MH  - Gyrus Cinguli/diagnostic imaging
MH  - *Psychotic Disorders
MH  - Brain
MH  - Magnetic Resonance Imaging
OTO - NOTNLM
OT  - Anterior cingulate cortex
OT  - Bipolar disorder
OT  - First-episode schizophrenia
OT  - Resting-state functional connectivity
OT  - Transdiagnostic signature
COIS- Conflict of interest The authors have declared that there are no conflicts of 
      interest in relation to the subject of this study.
EDAT- 2023/03/09 06:00
MHDA- 2023/04/18 06:41
CRDT- 2023/03/08 18:13
PHST- 2021/11/22 00:00 [received]
PHST- 2022/04/20 00:00 [revised]
PHST- 2023/02/20 00:00 [accepted]
PHST- 2023/04/18 06:41 [medline]
PHST- 2023/03/09 06:00 [pubmed]
PHST- 2023/03/08 18:13 [entrez]
AID - S0920-9964(23)00075-0 [pii]
AID - 10.1016/j.schres.2023.02.023 [doi]
PST - ppublish
SO  - Schizophr Res. 2023 Apr;254:155-162. doi: 10.1016/j.schres.2023.02.023. Epub 2023 
      Mar 7.