PMID- 36889293
OWN - NLM
STAT- MEDLINE
DCOM- 20230602
LR  - 20230609
IS  - 1423-0348 (Electronic)
IS  - 0033-3190 (Linking)
VI  - 92
IP  - 2
DP  - 2023
TI  - Inhibitory Control Training Enhanced by Transcranial Direct Current Stimulation 
      to Reduce Binge Eating Episodes: Findings from the Randomized Phase II ACCElect 
      Trial.
PG  - 101-112
LID - 10.1159/000529117 [doi]
AB  - INTRODUCTION: Binge eating disorder (BED) is characterized by recurrent binge 
      eating (BE) episodes with loss of control. Inhibitory control impairments, 
      including alterations in dorsolateral prefrontal cortex (dlPFC) functioning, have 
      been described for BED. A targeted modulation of inhibitory control circuits by 
      the combination of inhibitory control training and transcranial brain stimulation 
      could be promising. OBJECTIVE: The aim of the study was to demonstrate 
      feasibility and clinical effects of a transcranial direct current stimulation 
      (tDCS)-enhanced inhibitory control training to reduce BE episodes and to generate 
      an empirical basis for a confirmatory trial. METHODS: We performed a monocentric 
      clinical phase II double-blind randomized trial with two parallel arms. Forty-one 
      adult outpatients with full-syndrome BED according to DSM-5 received six sessions 
      of food-related inhibitory control training, randomly combined with 2 mA verum or 
      sham tDCS of the right dlPFC. The main outcome was BE frequency within a 4-week 
      interval after treatment termination (T8; primary) and at 12-week follow-up (T9; 
      secondary) as compared to baseline. RESULTS: BE frequency was reduced in the sham 
      group from 15.5 to 5.9 (T8) and to 6.8 (T9); in the verum group, the reduction 
      was 18.6 to 4.4 (T8) resp. 3.8 (T9). Poisson regression with the study arm as the 
      factor and baseline BE frequency as the covariate revealed a p value of 0.34 for 
      T8 and 0.026 for T9. Sham and real tDCS differed at T9 in BE frequency. 
      CONCLUSIONS: Inhibitory control training enhanced by tDCS is safe in patients 
      with BED and results in a substantial and sustainable reduction in BE frequency 
      which unfolds over several weeks post-treatment. These results constitute the 
      empirical basis for a confirmatory trial.
CI  - (c) 2023 S. Karger AG, Basel.
FAU - Giel, Katrin E
AU  - Giel KE
AD  - Department of Psychosomatic Medicine und Psychotherapy, Medical University 
      Hospital Tubingen, Eberhard Karls University Tubingen, Tubingen, Germany.
AD  - Center of Excellence for Eating Disorders, Tubingen, Germany.
FAU - Schag, Kathrin
AU  - Schag K
AD  - Department of Psychosomatic Medicine und Psychotherapy, Medical University 
      Hospital Tubingen, Eberhard Karls University Tubingen, Tubingen, Germany.
AD  - Center of Excellence for Eating Disorders, Tubingen, Germany.
FAU - Max, Sebastian M
AU  - Max SM
AD  - Department of Psychosomatic Medicine und Psychotherapy, Medical University 
      Hospital Tubingen, Eberhard Karls University Tubingen, Tubingen, Germany.
AD  - Center of Excellence for Eating Disorders, Tubingen, Germany.
AD  - Department of Psychiatry and Psychotherapy, University Hospital of Psychiatry and 
      Psychotherapy, Tubingen, Germany.
FAU - Martus, Peter
AU  - Martus P
AD  - Institute for Clinical Epidemiology and Applied Biostatistics, Medical Faculty, 
      Eberhard Karls University Tubingen, Tubingen, Germany.
FAU - Zipfel, Stephan
AU  - Zipfel S
AD  - Department of Psychosomatic Medicine und Psychotherapy, Medical University 
      Hospital Tubingen, Eberhard Karls University Tubingen, Tubingen, Germany.
AD  - Center of Excellence for Eating Disorders, Tubingen, Germany.
FAU - Fallgatter, Andreas J
AU  - Fallgatter AJ
AD  - Department of Psychiatry and Psychotherapy, University Hospital of Psychiatry and 
      Psychotherapy, Tubingen, Germany.
FAU - Plewnia, Christian
AU  - Plewnia C
AD  - Department of Psychiatry and Psychotherapy, University Hospital of Psychiatry and 
      Psychotherapy, Tubingen, Germany.
LA  - eng
PT  - Clinical Trial, Phase II
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20230308
PL  - Switzerland
TA  - Psychother Psychosom
JT  - Psychotherapy and psychosomatics
JID - 0024046
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Transcranial Direct Current Stimulation/methods
MH  - *Binge-Eating Disorder/therapy
MH  - Double-Blind Method
MH  - Prefrontal Cortex
OTO - NOTNLM
OT  - Binge eating disorder
OT  - Food
OT  - Inhibitory control
OT  - Training
OT  - Transcranial direct current stimulation
EDAT- 2023/03/09 06:00
MHDA- 2023/06/02 06:42
CRDT- 2023/03/08 18:23
PHST- 2022/09/20 00:00 [received]
PHST- 2023/01/05 00:00 [accepted]
PHST- 2023/06/02 06:42 [medline]
PHST- 2023/03/09 06:00 [pubmed]
PHST- 2023/03/08 18:23 [entrez]
AID - 000529117 [pii]
AID - 10.1159/000529117 [doi]
PST - ppublish
SO  - Psychother Psychosom. 2023;92(2):101-112. doi: 10.1159/000529117. Epub 2023 Mar 
      8.