PMID- 36889483
OWN - NLM
STAT- MEDLINE
DCOM- 20230322
LR  - 20230412
IS  - 1095-953X (Electronic)
IS  - 0969-9961 (Linking)
VI  - 179
DP  - 2023 Apr
TI  - Microglia and macrophages in the neuro-glia-vascular unit: From identity to 
      functions.
PG  - 106066
LID - S0969-9961(23)00080-3 [pii]
LID - 10.1016/j.nbd.2023.106066 [doi]
AB  - Although both are myeloid cells located surrounding cerebral vasculature, 
      vessel-associated microglia (VAM) and perivascular macrophages (PVMs) can be 
      distinguished by their distinct morphologies, signatures and microscopic 
      location. As key component of neuro-glia-vascular unit (NGVU), they play 
      prominent roles in neurovasculature development and pathological process of 
      various central nervous system (CNS) diseases, including phagocytosis, 
      angiogenesis, vessel damage/protection and blood flow regulation, therefore 
      serving as potential targets for therapeutics of a broad array of CNS diseases. 
      Herein, we will provide a comprehensive overview of heterogeneity of VAM/PVMs, 
      highlight limitations of current understanding in this field, and discuss 
      possible directions of future investigations.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Chen, Shuning
AU  - Chen S
AD  - Department of Critical Care Medicine of Huashan Hospital, State Key Laboratory of 
      Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of 
      Brain Science, Fudan University, Shanghai, China.
FAU - Li, Jiaying
AU  - Li J
AD  - Department of Critical Care Medicine of Huashan Hospital, State Key Laboratory of 
      Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of 
      Brain Science, Fudan University, Shanghai, China.
FAU - Meng, Shan
AU  - Meng S
AD  - Department of Critical Care Medicine of Huashan Hospital, State Key Laboratory of 
      Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of 
      Brain Science, Fudan University, Shanghai, China.
FAU - He, Tingyu
AU  - He T
AD  - Department of Critical Care Medicine of Huashan Hospital, State Key Laboratory of 
      Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of 
      Brain Science, Fudan University, Shanghai, China.
FAU - Shi, Ziyu
AU  - Shi Z
AD  - Department of Critical Care Medicine of Huashan Hospital, State Key Laboratory of 
      Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of 
      Brain Science, Fudan University, Shanghai, China.
FAU - Wang, Chenran
AU  - Wang C
AD  - Department of Critical Care Medicine of Huashan Hospital, State Key Laboratory of 
      Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of 
      Brain Science, Fudan University, Shanghai, China.
FAU - Wang, Yana
AU  - Wang Y
AD  - Department of Critical Care Medicine of Huashan Hospital, State Key Laboratory of 
      Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of 
      Brain Science, Fudan University, Shanghai, China.
FAU - Cao, Hui
AU  - Cao H
AD  - Department of Critical Care Medicine of Huashan Hospital, State Key Laboratory of 
      Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of 
      Brain Science, Fudan University, Shanghai, China.
FAU - Huang, Yichen
AU  - Huang Y
AD  - Department of Critical Care Medicine of Huashan Hospital, State Key Laboratory of 
      Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of 
      Brain Science, Fudan University, Shanghai, China.
FAU - Zhang, Yue
AU  - Zhang Y
AD  - Department of Critical Care Medicine of Huashan Hospital, State Key Laboratory of 
      Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of 
      Brain Science, Fudan University, Shanghai, China.
FAU - Gong, Ye
AU  - Gong Y
AD  - Department of Critical Care Medicine of Huashan Hospital, State Key Laboratory of 
      Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of 
      Brain Science, Fudan University, Shanghai, China. Electronic address: 
      gong_ye@fudan.edu.cn.
FAU - Gao, Yanqin
AU  - Gao Y
AD  - Department of Critical Care Medicine of Huashan Hospital, State Key Laboratory of 
      Medical Neurobiology, MOE Frontiers Center for Brain Science, and Institutes of 
      Brain Science, Fudan University, Shanghai, China. Electronic address: 
      yqgao@shmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230306
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
SB  - IM
MH  - Humans
MH  - *Microglia/physiology
MH  - Brain/pathology
MH  - Macrophages
MH  - Phagocytosis
MH  - *Central Nervous System Diseases/pathology
OTO - NOTNLM
OT  - Angiogenesis
OT  - Blood flow regulation
OT  - Perivascular macrophages
OT  - Phagocytosis
OT  - Single-cell RNA sequencing
OT  - Vessel-associated microglia
COIS- Declaration of Competing Interest The authors declare no comflict of interest.
EDAT- 2023/03/09 06:00
MHDA- 2023/03/23 06:00
CRDT- 2023/03/08 19:31
PHST- 2022/12/25 00:00 [received]
PHST- 2023/02/27 00:00 [revised]
PHST- 2023/03/02 00:00 [accepted]
PHST- 2023/03/09 06:00 [pubmed]
PHST- 2023/03/23 06:00 [medline]
PHST- 2023/03/08 19:31 [entrez]
AID - S0969-9961(23)00080-3 [pii]
AID - 10.1016/j.nbd.2023.106066 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2023 Apr;179:106066. doi: 10.1016/j.nbd.2023.106066. Epub 2023 Mar 
      6.