PMID- 36889692
OWN - NLM
STAT- MEDLINE
DCOM- 20230630
LR  - 20230630
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 70
IP  - 6
DP  - 2023 Jun 28
TI  - A case of vasoactive intestinal peptide-secreting tumor (VIPoma) arising from 
      MEN1 inactivation which recurred 15 years after the initial resection.
PG  - 573-579
LID - 10.1507/endocrj.EJ22-0578 [doi]
AB  - Vasoactive intestinal peptide-secreting tumors (VIPomas) are extremely rare 
      functional pancreatic neuroendocrine neoplasms (p-NENs) characterized by watery 
      diarrhea, hypokalemia, and achlorhydria. Here, we report the case of a 
      51-year-old female patient with VIPoma that recurred after a long-term 
      disease-free interval. This patient had been asymptomatic for approximately 15 
      years after the initial curative surgery for pancreatic VIPoma, with no 
      metastasis. The patient underwent a second curative surgery for the locally 
      recurrent VIPoma. Whole-exome sequencing of the resected tumor revealed a somatic 
      mutation in MEN1, which is reportedly responsible not only for multiple endocrine 
      neoplasia type 1 (MEN1) syndrome but also sporadic p-NENs. Symptoms were 
      controlled with lanreotide before and after surgery. The patient is alive with no 
      relapse following 14 months after surgery. This case demonstrates the importance 
      of long-term observation of patients with VIPoma.
FAU - Sakurai, Momoe
AU  - Sakurai M
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, School 
      of Medicine, Jichi Medical University, Tochigi 329-0498, Japan.
FAU - Wakabayashi, Tetsuji
AU  - Wakabayashi T
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, School 
      of Medicine, Jichi Medical University, Tochigi 329-0498, Japan.
FAU - Kondo, Yasuyuki
AU  - Kondo Y
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, School 
      of Medicine, Jichi Medical University, Tochigi 329-0498, Japan.
FAU - Ikeda, Eriko
AU  - Ikeda E
AD  - Department of Diagnostic Pathology, Jichi Medical University, Tochigi 329-0498, 
      Japan.
FAU - Watanabe, Koichi
AU  - Watanabe K
AD  - Department of Pathology and Tumor Biology, Kyoto University, Kyoto 606-8501, 
      Japan.
FAU - Takei, Akihito
AU  - Takei A
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, School 
      of Medicine, Jichi Medical University, Tochigi 329-0498, Japan.
FAU - Okazaki, Hiroaki
AU  - Okazaki H
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, School 
      of Medicine, Jichi Medical University, Tochigi 329-0498, Japan.
FAU - Okada, Kenta
AU  - Okada K
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, School 
      of Medicine, Jichi Medical University, Tochigi 329-0498, Japan.
FAU - Ebihara, Ken
AU  - Ebihara K
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, School 
      of Medicine, Jichi Medical University, Tochigi 329-0498, Japan.
FAU - Kakiuchi, Nobuyuki
AU  - Kakiuchi N
AD  - The Hakubi Center for Advanced Research, Kyoto University, Kyoto 606-8501, Japan.
FAU - Ogawa, Seishi
AU  - Ogawa S
AD  - Department of Pathology and Tumor Biology, Kyoto University, Kyoto 606-8501, 
      Japan.
FAU - Fukushima, Noriyoshi
AU  - Fukushima N
AD  - Department of Diagnostic Pathology, Jichi Medical University, Tochigi 329-0498, 
      Japan.
FAU - Ishibashi, Shun
AU  - Ishibashi S
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, School 
      of Medicine, Jichi Medical University, Tochigi 329-0498, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20230309
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
SB  - IM
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Vipoma/surgery/diagnosis/pathology
MH  - *Multiple Endocrine Neoplasia Type 1/complications/surgery
MH  - Vasoactive Intestinal Peptide
MH  - *Pancreatic Neoplasms/diagnosis
MH  - Diarrhea
OTO - NOTNLM
OT  - Case report
OT  - Lanreotide
OT  - MEN1
OT  - Pancreatic neuroendocrine neoplasm (p-NEN)
OT  - Vasoactive intestinal peptide-secreting tumor (VIPoma)
EDAT- 2023/03/09 06:00
MHDA- 2023/06/30 06:42
CRDT- 2023/03/08 20:12
PHST- 2023/06/30 06:42 [medline]
PHST- 2023/03/09 06:00 [pubmed]
PHST- 2023/03/08 20:12 [entrez]
AID - 10.1507/endocrj.EJ22-0578 [doi]
PST - ppublish
SO  - Endocr J. 2023 Jun 28;70(6):573-579. doi: 10.1507/endocrj.EJ22-0578. Epub 2023 
      Mar 9.