PMID- 36889737
OWN - NLM
STAT- MEDLINE
DCOM- 20231103
LR  - 20231108
IS  - 1880-3873 (Electronic)
IS  - 1340-3478 (Print)
IS  - 1340-3478 (Linking)
VI  - 30
IP  - 11
DP  - 2023 Nov 1
TI  - Malondialdehyde-Modified Low-Density Lipoprotein as a Predictor of Major Adverse 
      Limb Events after Endovascular Therapy in Patients with Lower Extremity Arterial 
      Disease.
PG  - 1612-1621
LID - 10.5551/jat.64091 [doi]
AB  - AIM: Adverse limb events after endovascular therapy (EVT) are a major concern. 
      This study aimed to investigate the relationship between serum 
      malondialdehyde-modified low-density lipoprotein (MDA-LDL) level, a potentially 
      potent indicator of atherosclerosis, and clinical outcomes after EVT in patients 
      with lower extremity arterial disease (LEAD). METHODS: A total of 208 LEAD 
      patients who underwent EVT and MDA-LDL measurements were retrospectively 
      analyzed. Those with chronic limb-threatening ischemia (CLTI) were included in 
      the CLTI subgroup (n=106). Patients were further categorized into the High or Low 
      MDA-LDL groups according to the cut-off value calculated by receiver operating 
      characteristic analysis. Major adverse limb events (MALE), a composite of 
      cardiovascular death, limb-related death, major amputation, and target-limb 
      revascularization, were evaluated. RESULTS: MALE occurred in 73 (35%) patients. 
      The median follow-up interval was 17.4 months. The MDA-LDL cut-off values were 
      100.5 U/L (area under the curve [AUC] 0.651) in the overall population and 98.0 
      U/L (AUC 0.724) in the CLTI subgroup. Overall, the High MDA-LDL group showed 
      significantly higher total cholesterol (189.7+/-37.5 mg/dL vs. 159.3+/-32.0 mg/dL, 
      p＜0.01), low-density lipoprotein cholesterol (114.3+/-29.7 mg/dL vs. 87.3+/-25.3 
      mg/dL, p＜0.01), and triglyceride (166.9+/-91.1 mg/dL vs. 115.8+/-52.3 mg/dL, p＜0.01) 
      than the Low MDA-LDL group. Multivariate Cox regression analyses revealed that 
      MDA-LDL and C-reactive protein were independent predictors of MALE. In the CLTI 
      subgroup, MDA-LDL was an independent predictor of MALE. The High MDA-LDL group 
      showed worse MALE-free survival rates than the Low MDA-LDL group in overall 
      (p＜0.01) and in the CLTI subgroup (p=0.01). CONCLUSIONS: Serum MDA-LDL level was 
      associated with MALE after EVT.
FAU - Yokoi, Masashi
AU  - Yokoi M
AD  - Department of Cardiology, Nagoya City University Graduate School of Medical 
      Sciences.
FAU - Ito, Tsuyoshi
AU  - Ito T
AD  - Department of Cardiology, Nagoya City University Graduate School of Medical 
      Sciences.
FAU - Kawada, Yu
AU  - Kawada Y
AD  - Department of Cardiology, Nagoya City University Graduate School of Medical 
      Sciences.
FAU - Mizoguchi, Tatsuya
AU  - Mizoguchi T
AD  - Department of Cardiology, Nagoya City University Graduate School of Medical 
      Sciences.
FAU - Yamamoto, Junki
AU  - Yamamoto J
AD  - Department of Cardiology, Nagoya City University Graduate School of Medical 
      Sciences.
FAU - Mori, Kento
AU  - Mori K
AD  - Department of Cardiology, Nagoya City University Graduate School of Medical 
      Sciences.
FAU - Nakasuka, Kosuke
AU  - Nakasuka K
AD  - Department of Cardiology, Nagoya City University Graduate School of Medical 
      Sciences.
FAU - Kikuchi, Shohei
AU  - Kikuchi S
AD  - Department of Cardiology, Nagoya City University Graduate School of Medical 
      Sciences.
FAU - Fujita, Hiroshi
AU  - Fujita H
AD  - Department of Cardiology, Nagoya City University Graduate School of Medical 
      Sciences.
FAU - Kitada, Shuichi
AU  - Kitada S
AD  - Department of Cardiology, Nagoya City University Graduate School of Medical 
      Sciences.
FAU - Goto, Toshihiko
AU  - Goto T
AD  - Department of Cardiology, Nagoya City University Graduate School of Medical 
      Sciences.
FAU - Seo, Yoshihiro
AU  - Seo Y
AD  - Department of Cardiology, Nagoya City University Graduate School of Medical 
      Sciences.
LA  - eng
PT  - Journal Article
DEP - 20230309
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 0 (Cholesterol, LDL)
SB  - IM
MH  - Humans
MH  - Treatment Outcome
MH  - Malondialdehyde
MH  - Retrospective Studies
MH  - *Peripheral Arterial Disease/surgery
MH  - Risk Factors
MH  - Lower Extremity/blood supply
MH  - Cholesterol, LDL
MH  - *Endovascular Procedures/adverse effects
MH  - Ischemia/surgery
MH  - Limb Salvage
PMC - PMC10627766
OTO - NOTNLM
OT  - EVT
OT  - MDA-LDL
OT  - Outcome
OT  - Oxidative stress
OT  - Oxidized LDL
COIS- The authors declare no conflicts of interest.
EDAT- 2023/03/09 06:00
MHDA- 2023/11/03 06:44
PMCR- 2023/11/01
CRDT- 2023/03/08 20:13
PHST- 2023/11/03 06:44 [medline]
PHST- 2023/03/09 06:00 [pubmed]
PHST- 2023/03/08 20:13 [entrez]
PHST- 2023/11/01 00:00 [pmc-release]
AID - DN/JST.JSTAGE/jat/64091 [pii]
AID - 10.5551/jat.64091 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2023 Nov 1;30(11):1612-1621. doi: 10.5551/jat.64091. Epub 
      2023 Mar 9.