PMID- 36890410
OWN - NLM
STAT- MEDLINE
DCOM- 20230907
LR  - 20230913
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Print)
IS  - 1933-7191 (Linking)
VI  - 30
IP  - 9
DP  - 2023 Sep
TI  - The Effects of Treatment with Icariin on Immune Tolerance in the Recurrent 
      Spontaneous Abortion Mice.
PG  - 2794-2804
LID - 10.1007/s43032-023-01185-0 [doi]
AB  - Recurrent spontaneous abortion (RSA) is the most common pregnancy-related 
      complication, affecting 1-5% of pregnancies. Currently, immune imbalance at the 
      maternal-fetal interface is one of the main causes of recurrent abortion. Icariin 
      (ICA) can exert immunomodulatory effects in a variety of autoimmune diseases. 
      Nevertheless, it has not been reported for use in recurrent abortion. In this 
      study, to clarify the effects and mechanisms of ICA for recurrent abortion, 
      female mice CBA/J were randomly divided into Normal group, RSA group and 
      RSA + ICA group. From 0.5 days of pregnancy to 12.5 days, the RSA + ICA group was 
      subjected to orally ICA (50 mg/Kg) daily, and the Normal group and the RSA group 
      were given with an equal volume of distilled water. The results showed the amount 
      of reabsorbed embryo in the RSA group was significantly higher than that in the 
      normal-pregnancy group. However, ICA treatment showed a rescue effect on 
      spontaneous abortion in RSA mice. ICA was able to increase the ratio of the 
      labyrinth to total placental area in abortion-prone model. Further investigation 
      showed that ICA treatment can expand the regulatory T cell (Treg) population in 
      mice prone to abortion, significantly decrease the populations of Th1 cells, and 
      reduce the expression of pro-inflammatory factors. Additionally, ICA treatment 
      was able to decrease the expression of mechanical target of rapamycin (mTOR) in 
      the placenta. ICA may increase Treg cell expansion and reducing pro-inflammatory 
      factors expression via the mTOR pathway, then reducing placental inflammation and 
      improving pregnancy outcomes in abortion-prone mice.
CI  - (c) 2023. The Author(s).
FAU - Peng, Fang
AU  - Peng F
AD  - Chengdu University of Traditional Chinese Medicine, Chengdu, China.
FAU - Han, Zhongyu
AU  - Han Z
AD  - Chengdu University of Traditional Chinese Medicine, Chengdu, China.
FAU - Chen, Haoran
AU  - Chen H
AD  - Chengdu University of Traditional Chinese Medicine, Chengdu, China.
FAU - Zhang, Qinxiu
AU  - Zhang Q
AD  - Chengdu University of Traditional Chinese Medicine, Chengdu, China.
FAU - Liu, Chi
AU  - Liu C
AD  - Department of Nephrology, Sichuan Academy of Medical Science and Sichuan 
      Provincial People's Hospital, Sichuan Renal Disease Clinical Research Center, 
      University of Electronic Science and Technology of China, Chengdu, China. 
      liuchi1985@163.com.
AD  - Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, 
      Chengdu, 610072, China. liuchi1985@163.com.
FAU - Liang, Xin
AU  - Liang X
AUID- ORCID: 0000-0003-2167-5368
AD  - Chengdu University of Traditional Chinese Medicine, Chengdu, China. 
      liangxin@cdutcm.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230308
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - VNM47R2QSQ (icariin)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Humans
MH  - Female
MH  - Pregnancy
MH  - Animals
MH  - Mice
MH  - *Abortion, Spontaneous
MH  - Placenta
MH  - Mice, Inbred CBA
MH  - *Abortion, Habitual
MH  - TOR Serine-Threonine Kinases
MH  - Immune Tolerance
PMC - PMC10480255
OTO - NOTNLM
OT  - Icariin
OT  - Immune tolerance
OT  - Recurrent spontaneous abortion
OT  - Treg cells
OT  - mTOR signaling pathway
COIS- The authors declare no competing interests.
EDAT- 2023/03/09 06:00
MHDA- 2023/09/07 06:42
PMCR- 2023/03/08
CRDT- 2023/03/08 23:25
PHST- 2022/07/03 00:00 [received]
PHST- 2023/01/29 00:00 [accepted]
PHST- 2023/09/07 06:42 [medline]
PHST- 2023/03/09 06:00 [pubmed]
PHST- 2023/03/08 23:25 [entrez]
PHST- 2023/03/08 00:00 [pmc-release]
AID - 10.1007/s43032-023-01185-0 [pii]
AID - 1185 [pii]
AID - 10.1007/s43032-023-01185-0 [doi]
PST - ppublish
SO  - Reprod Sci. 2023 Sep;30(9):2794-2804. doi: 10.1007/s43032-023-01185-0. Epub 2023 
      Mar 8.