PMID- 36890496
OWN - NLM
STAT- MEDLINE
DCOM- 20230310
LR  - 20230313
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Mar 8
TI  - Effect of helicobacter pylori infection eradication on serum level of anti-tissue 
      transglutaminase in children with celiac disease.
PG  - 116
LID - 10.1186/s12887-023-03934-1 [doi]
LID - 116
AB  - BACKGROUND: Evidence shows the increase of anti-tissue transglutaminase (tTG) 
      levels in various conditions, including infectious agents, independently of 
      celiac disease (CD). The aim of this study was to investigate the effect of 
      helicobacter pylori (H.pylori) infection eradication on serum level of tTG in 
      children with CD. METHODS: This study was conducted on children aged 2 to 18 who 
      referred to reference hospitals for diagnosis of CD. After upper endoscopy and 
      biopsy to confirm CD and H.pylori infection, the children were divided into three 
      groups (including group one: 16 CD patients with positive H. pylori; group two: 
      16 non-CD patients with positive H. pylori; and group three: 56 CD patients with 
      negative H. pylori), respectively. The tTG level in study groups were compared 
      after the eradication of H.pylori. RESULTS: The mean age of the subjects in the 
      group one, two, and three was 9.7 +/- 3.33, 11.8 +/- 3.14, and 7.6 +/- 3.32 years, 
      respectively. Our results showed that in group one, mean tTG increased after 
      eradication of H.pylori infection, however, these changes were not significant 
      (182.43 vs. 157.18, P = 0.121). In the second group, although unlike the first 
      group, mean tTG decreased after eradication of the infection, but still these 
      changes were not significant (9.56 vs. 22.18, P = 0.449). Furthermore, at the 
      baseline level, the mean tTG in the group three was closer to the mean tTG in the 
      first group. CONCLUSION: Our findings showed that the eradication of H.pylori 
      infection does not have a significant effect on tTG levels in children with and 
      without CD.
CI  - (c) 2023. The Author(s).
FAU - Rohani, Pejman
AU  - Rohani P
AD  - Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of 
      Excellence, Children's Medical Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Zadeh, Maryam Monajam
AU  - Zadeh MM
AD  - Department of Pathology, School of Medicine Pediatric Chronic Kidney Disease 
      Research Center, Childrens Medical Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Alimadadi, Hosein
AU  - Alimadadi H
AD  - Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of 
      Excellence, Children's Medical Center, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Sohouli, Mohammad Hassan
AU  - Sohouli MH
AD  - Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of 
      Excellence, Children's Medical Center, Tehran University of Medical Sciences, 
      Tehran, Iran. mohammadhassansohouli@gmail.com.
AD  - Student Research Committee, Department of Clinical Nutrition and Dietetics, 
      Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran. mohammadhassansohouli@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20230308
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
SB  - IM
MH  - Humans
MH  - Child
MH  - *Celiac Disease/diagnosis
MH  - *Helicobacter pylori
MH  - *Helicobacter Infections/complications/drug therapy
MH  - Biopsy
MH  - Endoscopy
PMC - PMC9993645
OTO - NOTNLM
OT  - Anti-tissue transglutaminase
OT  - Celiac
OT  - Children
OT  - Helicobacter pylori
COIS- We, the authors, declare that we had no competing interests.
EDAT- 2023/03/09 06:00
MHDA- 2023/03/11 06:00
PMCR- 2023/03/08
CRDT- 2023/03/08 23:36
PHST- 2022/12/14 00:00 [received]
PHST- 2023/02/25 00:00 [accepted]
PHST- 2023/03/08 23:36 [entrez]
PHST- 2023/03/09 06:00 [pubmed]
PHST- 2023/03/11 06:00 [medline]
PHST- 2023/03/08 00:00 [pmc-release]
AID - 10.1186/s12887-023-03934-1 [pii]
AID - 3934 [pii]
AID - 10.1186/s12887-023-03934-1 [doi]
PST - epublish
SO  - BMC Pediatr. 2023 Mar 8;23(1):116. doi: 10.1186/s12887-023-03934-1.