PMID- 36891057
OWN - NLM
STAT- MEDLINE
DCOM- 20230310
LR  - 20230314
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 14
DP  - 2023
TI  - Nerve conduction velocity is independently associated with bone mineral density 
      in type 2 diabetes mellitus.
PG  - 1109322
LID - 10.3389/fendo.2023.1109322 [doi]
LID - 1109322
AB  - AIM: This study investigated the association between nerve conduction velocity 
      (NCV) and bone mineral density (BMD) in patients with type 2 diabetes mellitus 
      (T2DM). METHODS: This study retrospectively collected medical data of T2DM 
      patients who underwent dual-energy X-ray absorptiometry and nerve conduction 
      study at the Shanghai Ruijin Hospital, Shanghai, China. The primary outcome was 
      the total hip BMD T-score. The main independent variables were motor nerve 
      conduction velocities (MCVs), sensory nerve conduction velocities (SCVs), and 
      composite Z-scores of MCV and SCV. T2DM patients were divided into total hip BMD 
      T-scores < -1 and total hip BMD T-scores >/= -1 groups. The association between the 
      primary outcome and main independent variables was evaluated by Pearson bivariate 
      correlation and multivariate linear regression. RESULTS: 195 female and 415 male 
      patients with T2DM were identified. In male patients with T2DM, bilateral ulnar, 
      median, and tibial MCVs and bilateral sural SCVs were lower in the total hip BMD 
      T-score < -1 group than T-score >/= -1 group (P < 0.05). Bilateral ulnar, median, 
      and tibial MCVs, and bilateral sural SCVs showed positive correlations with total 
      hip BMD T-score in male patients with T2DM (P < 0.05). Bilateral ulnar and tibial 
      MCVs, bilateral sural SCVs, and composite MCV SCV and MSCV Z-scores were 
      independently and positively associated with total hip BMD T-score in male 
      patients with T2DM, respectively (P < 0.05). NCV did not show significant 
      correlation with the total hip BMD T-score in female patients with T2DM. 
      CONCLUSION: NCV showed positive association with total hip BMD in male patients 
      with T2DM. A decline in NCV indicates an elevated risk of low BMD 
      (osteopenia/osteoporosis) in male patients with T2DM.
CI  - Copyright (c) 2023 Chen, Wang, Pan, Zhang, Zhu, Jiang, Kong, Xie, Sun, Tao, Liu and 
      Zhao.
FAU - Chen, Xiao-Jing
AU  - Chen XJ
AD  - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine 
      and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
AD  - Shanghai National Clinical Research Center for metabolic Diseases, Key Laboratory 
      for Endocrine and Metabolic Diseases of the National Health Commission of the 
      People's Republic of China, Shanghai National Center for Translational Medicine, 
      Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Wang, Xiao-Feng
AU  - Wang XF
AD  - Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
FAU - Pan, Zheng-Can
AU  - Pan ZC
AD  - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine 
      and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
AD  - Shanghai National Clinical Research Center for metabolic Diseases, Key Laboratory 
      for Endocrine and Metabolic Diseases of the National Health Commission of the 
      People's Republic of China, Shanghai National Center for Translational Medicine, 
      Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Zhang, Deng
AU  - Zhang D
AD  - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine 
      and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
AD  - Shanghai National Clinical Research Center for metabolic Diseases, Key Laboratory 
      for Endocrine and Metabolic Diseases of the National Health Commission of the 
      People's Republic of China, Shanghai National Center for Translational Medicine, 
      Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Zhu, Ke-Cheng
AU  - Zhu KC
AD  - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine 
      and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
AD  - Shanghai National Clinical Research Center for metabolic Diseases, Key Laboratory 
      for Endocrine and Metabolic Diseases of the National Health Commission of the 
      People's Republic of China, Shanghai National Center for Translational Medicine, 
      Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Jiang, Tao
AU  - Jiang T
AD  - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine 
      and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
AD  - Shanghai National Clinical Research Center for metabolic Diseases, Key Laboratory 
      for Endocrine and Metabolic Diseases of the National Health Commission of the 
      People's Republic of China, Shanghai National Center for Translational Medicine, 
      Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Kong, Xiao-Ke
AU  - Kong XK
AD  - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine 
      and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
AD  - Shanghai National Clinical Research Center for metabolic Diseases, Key Laboratory 
      for Endocrine and Metabolic Diseases of the National Health Commission of the 
      People's Republic of China, Shanghai National Center for Translational Medicine, 
      Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Xie, Rui
AU  - Xie R
AD  - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine 
      and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
AD  - Shanghai National Clinical Research Center for metabolic Diseases, Key Laboratory 
      for Endocrine and Metabolic Diseases of the National Health Commission of the 
      People's Republic of China, Shanghai National Center for Translational Medicine, 
      Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Sun, Li-Hao
AU  - Sun LH
AD  - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine 
      and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
AD  - Shanghai National Clinical Research Center for metabolic Diseases, Key Laboratory 
      for Endocrine and Metabolic Diseases of the National Health Commission of the 
      People's Republic of China, Shanghai National Center for Translational Medicine, 
      Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Tao, Bei
AU  - Tao B
AD  - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine 
      and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
AD  - Shanghai National Clinical Research Center for metabolic Diseases, Key Laboratory 
      for Endocrine and Metabolic Diseases of the National Health Commission of the 
      People's Republic of China, Shanghai National Center for Translational Medicine, 
      Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Liu, Jian-Min
AU  - Liu JM
AD  - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine 
      and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
AD  - Shanghai National Clinical Research Center for metabolic Diseases, Key Laboratory 
      for Endocrine and Metabolic Diseases of the National Health Commission of the 
      People's Republic of China, Shanghai National Center for Translational Medicine, 
      Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
FAU - Zhao, Hong-Yan
AU  - Zhao HY
AD  - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine 
      and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
AD  - Shanghai National Clinical Research Center for metabolic Diseases, Key Laboratory 
      for Endocrine and Metabolic Diseases of the National Health Commission of the 
      People's Republic of China, Shanghai National Center for Translational Medicine, 
      Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230220
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Bone Density/physiology
MH  - Retrospective Studies
MH  - China/epidemiology
MH  - Neural Conduction/physiology
PMC - PMC9987338
OTO - NOTNLM
OT  - bone mineral density
OT  - diabetic peripheral neuropathy
OT  - nerve conduction velocity
OT  - osteoporosis
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/03/10 06:00
MHDA- 2023/03/11 06:00
PMCR- 2023/01/01
CRDT- 2023/03/09 02:08
PHST- 2022/11/27 00:00 [received]
PHST- 2023/02/09 00:00 [accepted]
PHST- 2023/03/09 02:08 [entrez]
PHST- 2023/03/10 06:00 [pubmed]
PHST- 2023/03/11 06:00 [medline]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2023.1109322 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2023 Feb 20;14:1109322. doi: 
      10.3389/fendo.2023.1109322. eCollection 2023.