PMID- 36891697 OWN - NLM STAT- MEDLINE DCOM- 20230310 LR - 20230310 IS - 1007-3418 (Print) IS - 1007-3418 (Linking) VI - 30 IP - 11 DP - 2022 Nov 20 TI - [Characteristic analysis of patients with type 2 diabetes mellitus combined with advanced stage chronic liver disease: a community population-based cross-sectional study in Heping District, Shenyang City (CHESS-LN 2101)]. PG - 1194-1200 LID - 10.3760/cma.j.cn501113-20210810-00390 [doi] AB - Objective: To investigate the prevalence and independent risk factors of non-alcoholic fatty liver disease (NAFLD) and advanced chronic liver disease among the type 2 diabetes mellitus (T2DM) population in the Shenyang community, so as to provide evidence for the prevention and control of T2DM combined with NAFLD. Methods: This cross-sectional study was conducted in July 2021. 644 T2DM cases from 13 communities in Heping District, Shenyang City were selected. All the surveyed subjects underwent physical examination (measurements of height, body mass index, neck circumference, waist circumference, abdominal circumference, hip circumference, and blood pressure), infection screening (excluding hepatitis B and C, AIDS, and syphilis), random fingertip blood glucose, controlled attenuation parameter (CAP), and liver stiffness measurement (LSM). The study subjects were divided into the non-advanced chronic liver disease group and the advanced chronic liver disease group according to whether the LSM value was greater than 10 kPa. Cirrhotic portal hypertension development was indicated in patients with LSM >/= 15 kPa. The comparison of multiple mean values among the sample groups was performed by analysis of variance when the normal distribution was met. Results: In the T2DM community population, there were 401 cases (62.27%) combined with NAFLD, 63 cases (9.78%) combined with advanced chronic liver disease, and 14 cases (2.17%) combined with portal hypertension. There were 581 cases in the non-advanced chronic liver disease group and 63 cases (9.78%) in the advanced chronic liver disease group (LSM >/=10 kPa), including 49 cases (7.61%) with 10 kPa/= 25 kPa. Age, body mass, body mass index, neck circumference, waist circumference, hip circumference, waist-to-height ratio, systolic blood pressure, and CAP were all statistically different between the non-advanced chronic liver disease group and the advanced chronic liver disease group (F=-1.983,-2.598,-4.091,-2.062,-3.909, -4.581,-4.295,-2.474, and -5.191, respectively; P<0.05). There was a statistically significant difference in terms of whether or not there was combined cerebrovascular disease (2=4.632, P=0.031); however, there were no statistically significant differences in terms of lifestyle, diabetes complications, and other complications (P>0.05). Conclusion: Patients with T2DM have a higher prevalence of NAFLD (62.27%) than those with advanced chronic liver disease (9.78%). 2.17% of T2DM cases in the community may not have had early diagnosis and early intervention, and they might have been combined with cirrhotic portal hypertension. So, the management of these patients should be strengthened. FAU - Lyu, C AU - Lyu C AD - Co-Management of Diabetes-Liver Disease Center of Shengyang, Shenyang 110006, China. FAU - Fu, W L AU - Fu WL AD - Department of Internal Medicine, Heping District Central Hospital, Shenyang 110001, China. FAU - Gu, Y AU - Gu Y AD - Front Center Working Group, the Sixth People's Hospital of Shenyang, Shenyang 110006, China. FAU - Wang, L S AU - Wang LS AD - Office of the Director, the Sixth People's Hospital of Shenyang, Shenyang 110006, China. FAU - Wang, X M AU - Wang XM AD - Department of Endocrinology, the Sixth People's Hospital of Shenyang, Shenyang 110006, China. FAU - Liu, X AU - Liu X AD - Co-Management of Diabetes-Liver Disease Center of Shengyang, Shenyang 110006, China. FAU - Qian, J M AU - Qian JM AD - Co-Management of Diabetes-Liver Disease Center of Shengyang, Shenyang 110006, China. FAU - Tao, Z AU - Tao Z AD - Department of Endoscopy, the Sixth People's Hospital of Shenyang, Shenyang 110006, China. FAU - Chen, Y AU - Chen Y AD - Beishi Community Health Service Center of Heping District of Shenyang, Shenyang 110000, China. FAU - Liu, C AU - Liu C AD - Center of Portal Hypertension, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China. FAU - He, R L AU - He RL AD - Center of Portal Hypertension, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China. FAU - Guan, X AU - Guan X AD - Department of Endocrinology, the Sixth People's Hospital of Shenyang, Shenyang 110006, China. FAU - Wang, Y AU - Wang Y AD - Department of Community Development, Heping District Health Bureau, Shenyang 110000, China. FAU - Wang, Y AU - Wang Y AD - Department of Community Development, Heping District Health Bureau, Shenyang 110000, China. FAU - Qi, X L AU - Qi XL AD - Center of Portal Hypertension, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China. LA - chi GR - 2019-MS-288/Liaoning Provincial Natural Science Foundation of China/ PT - English Abstract PT - Journal Article PL - China TA - Zhonghua Gan Zang Bing Za Zhi JT - Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology JID - 9710009 SB - IM MH - Humans MH - *Non-alcoholic Fatty Liver Disease/complications/epidemiology/pathology MH - *Diabetes Mellitus, Type 2/epidemiology/complications MH - Liver Cirrhosis/complications MH - Cross-Sectional Studies MH - *Elasticity Imaging Techniques MH - *Hypertension, Portal/complications MH - Liver/pathology EDAT- 2023/03/10 06:00 MHDA- 2023/03/11 06:00 CRDT- 2023/03/09 03:24 PHST- 2023/03/09 03:24 [entrez] PHST- 2023/03/10 06:00 [pubmed] PHST- 2023/03/11 06:00 [medline] AID - 10.3760/cma.j.cn501113-20210810-00390 [doi] PST - ppublish SO - Zhonghua Gan Zang Bing Za Zhi. 2022 Nov 20;30(11):1194-1200. doi: 10.3760/cma.j.cn501113-20210810-00390.