PMID- 36892201
OWN - NLM
STAT- MEDLINE
DCOM- 20230504
LR  - 20230504
IS  - 1348-0421 (Electronic)
IS  - 0385-5600 (Linking)
VI  - 67
IP  - 5
DP  - 2023 May
TI  - Nicotine- and tar-removed cigarette smoke extract modulates the antigen 
      presentation function of mouse bone marrow-derived dendritic cells.
PG  - 264-273
LID - 10.1111/1348-0421.13061 [doi]
AB  - Dendritic cells (DCs) take up antigens derived from pathogens such as bacteria 
      and viruses, and from tumor cells and induce the activation of antigen-specific T 
      cells through major histocompatibility complex (MHC)-mediated antigen 
      presentation. Mainstream cigarette smoke extract (CSE) has various effects, and 
      the effects of its major components, nicotine and tar, have been analyzed 
      extensively. Recently, the physiological effects of nicotine- and tar-removed CSE 
      (cCSE) have also been reported. However, the effects of cCSE on DC-mediated 
      immune responses remain unknown. In this study, we found that cCSE enhanced 
      lipopolysaccharide (LPS)-stimulated induction of the expression of MHC-I and 
      MHC-II on the cell surface of mouse bone marrow-derived DCs (BMDCs). In contrast, 
      cCSE suppressed the induction of CD86 induced by stimulation with curdlan and 
      interferon-gamma (IFN-gamma). In addition, cCSE suppressed the production of IL-12, 
      IL-23, and IL-10 by LPS and curdlan stimulation. In the presence of cCSE, 
      LPS-stimulated BMDCs showed enhanced activation of CD4 and CD8 T cells and 
      increased IL-2 production from T cells by antigen presentation in a 
      mixed-leukocyte reaction assay. In contrast, cCSE did not affect the activation 
      of T cells by curdlan- or IFN-gamma-stimulated BMDCs, and curdlan-stimulated BMDCs 
      suppressed IL-17 production from T cells and enhanced IFN-gamma production. These 
      results suggest that cCSE has different effects on the activation signals induced 
      by LPS, curdlan, and IFN-gamma in BMDCs and modulates the antigen presentation 
      function of BMDCs.
CI  - (c) 2023 The Societies and John Wiley & Sons Australia, Ltd.
FAU - Furuta, Kazuyuki
AU  - Furuta K
AUID- ORCID: 0000-0003-4068-8367
AD  - Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 
      University, Okayama, Japan.
FAU - Yoshioka, Takehiro
AU  - Yoshioka T
AD  - Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 
      University, Okayama, Japan.
FAU - Nishikaze, Kana
AU  - Nishikaze K
AD  - Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, 
      Mukogawa Women's University, Nishinomiya, Japan.
FAU - Yoshikawa, Noriko
AU  - Yoshikawa N
AD  - Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, 
      Mukogawa Women's University, Nishinomiya, Japan.
FAU - Nakamura, Kazuki
AU  - Nakamura K
AD  - Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, 
      Mukogawa Women's University, Nishinomiya, Japan.
FAU - Kaito, Chikara
AU  - Kaito C
AUID- ORCID: 0000-0002-2895-3386
AD  - Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 
      University, Okayama, Japan.
LA  - eng
GR  - Smoking Research Foundation/
GR  - 19K22523/Japan Society for the Promotion of Science/
GR  - 20K07030/Japan Society for the Promotion of Science/
GR  - 22H02869/Japan Society for the Promotion of Science/
GR  - 22K19435/Japan Society for the Promotion of Science/
PT  - Journal Article
DEP - 20230328
PL  - Australia
TA  - Microbiol Immunol
JT  - Microbiology and immunology
JID - 7703966
RN  - 6M3C89ZY6R (Nicotine)
RN  - 0 (Lipopolysaccharides)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Mice
MH  - Animals
MH  - *Antigen Presentation
MH  - Nicotine/pharmacology/metabolism
MH  - Lipopolysaccharides/metabolism
MH  - Bone Marrow/metabolism
MH  - *Cigarette Smoking
MH  - Interferon-gamma/metabolism
MH  - Dendritic Cells
MH  - Mice, Inbred C57BL
OTO - NOTNLM
OT  - T cell activation
OT  - antigen presentation
OT  - cigarette smoke extract
OT  - dendritic cell
OT  - major histocompatibility complex
EDAT- 2023/03/10 06:00
MHDA- 2023/05/04 12:41
CRDT- 2023/03/09 08:22
PHST- 2023/03/01 00:00 [revised]
PHST- 2022/07/12 00:00 [received]
PHST- 2023/03/06 00:00 [accepted]
PHST- 2023/05/04 12:41 [medline]
PHST- 2023/03/10 06:00 [pubmed]
PHST- 2023/03/09 08:22 [entrez]
AID - 10.1111/1348-0421.13061 [doi]
PST - ppublish
SO  - Microbiol Immunol. 2023 May;67(5):264-273. doi: 10.1111/1348-0421.13061. Epub 
      2023 Mar 28.