PMID- 36893525 OWN - NLM STAT- MEDLINE DCOM- 20230503 LR - 20230503 IS - 1875-0834 (Electronic) IS - 1760-2734 (Linking) VI - 46 DP - 2023 Apr TI - Thin and hypokinetic myocardial segments in cats with cardiomyopathy. PG - 5-17 LID - S1760-2734(23)00009-7 [pii] LID - 10.1016/j.jvc.2023.02.002 [doi] AB - INTRODUCTION/OBJECTIVES: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic cardiomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV wall thinning was detected (pre-THyMS). ANIMALS: Eighty client-owned cats. MATERIALS AND METHODS: Retrospective multicenter study. Clinical records were searched for cats with THyMS, defined as LV segment(s) with end-diastolic wall thickness (LVWT) <3 mm and hypokinesis in the presence of >/=one LV segment(s) with LVWT >4 mm and normal wall motion. When available, echocardiograms pre-THyMS were assessed. Survival time was defined as time from first presentation with THyMS to death. RESULTS: Mean thickest LV wall segment (MaxLVWT) was 6.1 mm (95% CI 5.8-6.4 mm) and thinnest (MinLVWT) was 1.7 mm (95% CI 1.6-1.9 mm). The LV free wall was affected in 74%, apex in 13% and septum in 5%. Most cats (85%) presented with heart failure and/or arterial thromboembolism. Median circulating troponin I concentration was 1.4 ng/mL ([range 0.07-180 ng/mL]). Prior echocardiography results were available for 13/80 cats, a mean of 2.5 years pre-THyMS. In segments subsequently undergoing thinning, initial MaxLVWT measured 6.7 mm (95% CI 5.8-7.7 mm) vs. 1.9 mm (95% CI 1.5-2.4 mm) at last echocardiogram (P<0.0001). Survival data were available for 56/80 cats, median survival time after diagnosing THyMS was 153 days (95% CI 83-223 days). Cardiac histopathology in one cat revealed that THyMS was associated with severe transmural scarring. CONCLUSIONS: Cats with THyMS had advanced cardiomyopathy and a poor prognosis. CI - Copyright (c) 2023 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Novo Matos, J AU - Novo Matos J AD - Department of Veterinary Medicine, University of Cambridge, Madingley Road, CB3 0ES, Cambridge, UK; Clinical Science and Services, Royal Veterinary College, Hawkshead Lane, Hatfield, Hertfordshire, AL9 7TA, London, UK. Electronic address: jms330@cam.ac.uk. FAU - Sargent, J AU - Sargent J AD - Southern Counties Veterinary Specialists, Unit 6, Forest Corner Farm, Hangersley, BH24 3JW, Ringwood, Hampshire, UK. FAU - Silva, J AU - Silva J AD - Department of Veterinary Medicine, University of Cambridge, Madingley Road, CB3 0ES, Cambridge, UK; North Downs Specialist Referrals, The Friesian Buildings 3 & 4, Brewer Street, RH1 4QP, Bletchingley, Surrey, UK. FAU - Payne, J R AU - Payne JR AD - Langford Vets Small Animal Referral Hospital, University of Bristol, Langford House, BS40 5DU, Langford, UK. FAU - Seo, J AU - Seo J AD - Animal Referral Centre, 224 Albany Highway, Schnapper Rock, 0632, Auckland, New Zealand. FAU - Spalla, I AU - Spalla I AD - Ospedale Veterinario San Francesco, Via Feltrina, 29, 31038, Castagnole, Milan, Italy. FAU - Borgeat, K AU - Borgeat K AD - Langford Vets Small Animal Referral Hospital, University of Bristol, Langford House, BS40 5DU, Langford, UK. FAU - Loureiro, J AU - Loureiro J AD - North Downs Specialist Referrals, The Friesian Buildings 3 & 4, Brewer Street, RH1 4QP, Bletchingley, Surrey, UK. FAU - Pereira, N AU - Pereira N AD - Freelance Cardiology, Salstrasse 92, 8400, Winterthur, Switzerland. FAU - Simcock, I C AU - Simcock IC AD - Department of Clinical Radiology, Great Ormond Street Hospital for Children, Great Ormond Street, WC1N 3JH, London, UK; UCL Great Ormond Street Institute of Child Health, Great Ormond Street Hospital for Children, Great Ormond Street, WC1N 3JH, London, UK; NIHR Great Ormond Street Hospital Biomedical Research Centre, Great Ormond Street Hospital Biomedical Research Centre, London, UK. FAU - Hutchinson, J C AU - Hutchinson JC AD - Department of Clinical Radiology, Great Ormond Street Hospital for Children, Great Ormond Street, WC1N 3JH, London, UK; UCL Great Ormond Street Institute of Child Health, Great Ormond Street Hospital for Children, Great Ormond Street, WC1N 3JH, London, UK; NIHR Great Ormond Street Hospital Biomedical Research Centre, Great Ormond Street Hospital Biomedical Research Centre, London, UK. FAU - Arthurs, O J AU - Arthurs OJ AD - Department of Clinical Radiology, Great Ormond Street Hospital for Children, Great Ormond Street, WC1N 3JH, London, UK; UCL Great Ormond Street Institute of Child Health, Great Ormond Street Hospital for Children, Great Ormond Street, WC1N 3JH, London, UK; NIHR Great Ormond Street Hospital Biomedical Research Centre, Great Ormond Street Hospital Biomedical Research Centre, London, UK. FAU - Luis Fuentes, V AU - Luis Fuentes V AD - Clinical Science and Services, Royal Veterinary College, Hawkshead Lane, Hatfield, Hertfordshire, AL9 7TA, London, UK. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20230210 PL - Netherlands TA - J Vet Cardiol JT - Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology JID - 101163270 SB - IM MH - Humans MH - Cats MH - Animals MH - Myocardium/pathology MH - *Cardiomyopathy, Hypertrophic/veterinary MH - Echocardiography/veterinary MH - Retrospective Studies MH - *Heart Failure/veterinary MH - *Cat Diseases OTO - NOTNLM OT - Cardiomyopathy of non-specific phenotype OT - Fibrosis OT - Hypertrophic cardiomyopathy OT - Infarct OT - Micro-CT COIS- Conflicts of Interest Statement The authors do not have any conflicts of interest to disclose. EDAT- 2023/03/10 06:00 MHDA- 2023/05/03 06:42 CRDT- 2023/03/09 18:08 PHST- 2022/02/22 00:00 [received] PHST- 2023/01/30 00:00 [revised] PHST- 2023/02/08 00:00 [accepted] PHST- 2023/05/03 06:42 [medline] PHST- 2023/03/10 06:00 [pubmed] PHST- 2023/03/09 18:08 [entrez] AID - S1760-2734(23)00009-7 [pii] AID - 10.1016/j.jvc.2023.02.002 [doi] PST - ppublish SO - J Vet Cardiol. 2023 Apr;46:5-17. doi: 10.1016/j.jvc.2023.02.002. Epub 2023 Feb 10.