PMID- 36893664
OWN - NLM
STAT- MEDLINE
DCOM- 20230411
LR  - 20230411
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 225
DP  - 2023 May
TI  - Nanoparticles loaded with pharmacologically active plant-derived natural 
      products: Biomedical applications and toxicity.
PG  - 113214
LID - S0927-7765(23)00092-9 [pii]
LID - 10.1016/j.colsurfb.2023.113214 [doi]
AB  - Pharmacologically active natural products have played a significant role in the 
      history of drug development. They have acted as sources of therapeutic drugs for 
      various diseases such as cancer and infectious diseases. However, most natural 
      products suffer from poor water solubility and low bioavailability, limiting 
      their clinical applications. The rapid development of nanotechnology has opened 
      up new directions for applying natural products and numerous studies have 
      explored the biomedical applications of nanomaterials loaded with natural 
      products. This review covers the recent research on applying plant-derived 
      natural products (PDNPs) nanomaterials, including nanomedicines loaded with 
      flavonoids, non-flavonoid polyphenols, alkaloids, and quinones, especially their 
      use in treating various diseases. Furthermore, some drugs derived from natural 
      products can be toxic to the body, so the toxicity of them is discussed. This 
      comprehensive review includes fundamental discoveries and exploratory advances in 
      natural product-loaded nanomaterials that may be helpful for future clinical 
      development.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Peng, Shengjun
AU  - Peng S
AD  - School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation 
      (Yantai University), Ministry of Education, Collaborative Innovation Center of 
      Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, 
      Yantai University, Yantai 264005, PR China.
FAU - Wang, Yizhou
AU  - Wang Y
AD  - Institute of Crop Science, College of Agriculture and Biotechnology, Zhejiang 
      University, Zijingang Campus, Hangzhou 310058, PR China.
FAU - Sun, Zhifang
AU  - Sun Z
AD  - School of Public Health, Hangzhou Normal University, Hangzhou 311121, PR China.
FAU - Zhao, Laien
AU  - Zhao L
AD  - School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation 
      (Yantai University), Ministry of Education, Collaborative Innovation Center of 
      Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, 
      Yantai University, Yantai 264005, PR China.
FAU - Huang, Yanmei
AU  - Huang Y
AD  - School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation 
      (Yantai University), Ministry of Education, Collaborative Innovation Center of 
      Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, 
      Yantai University, Yantai 264005, PR China.
FAU - Fu, Xiaoxuan
AU  - Fu X
AD  - School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation 
      (Yantai University), Ministry of Education, Collaborative Innovation Center of 
      Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, 
      Yantai University, Yantai 264005, PR China.
FAU - Luo, Rongrui
AU  - Luo R
AD  - School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation 
      (Yantai University), Ministry of Education, Collaborative Innovation Center of 
      Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, 
      Yantai University, Yantai 264005, PR China.
FAU - Xue, Jianyue
AU  - Xue J
AD  - School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation 
      (Yantai University), Ministry of Education, Collaborative Innovation Center of 
      Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, 
      Yantai University, Yantai 264005, PR China.
FAU - Yang, Shubin
AU  - Yang S
AD  - School of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, 
      PR China. Electronic address: shubinyang@ytu.edu.cn.
FAU - Ling, Longbing
AU  - Ling L
AD  - School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation 
      (Yantai University), Ministry of Education, Collaborative Innovation Center of 
      Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, 
      Yantai University, Yantai 264005, PR China. Electronic address: 
      linglongbing@ytu.edu.cn.
FAU - Zhang, Zhuhong
AU  - Zhang Z
AD  - School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation 
      (Yantai University), Ministry of Education, Collaborative Innovation Center of 
      Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, 
      Yantai University, Yantai 264005, PR China. Electronic address: 
      zhzhang0608@ytu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230224
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Biological Products)
SB  - IM
MH  - Drug Delivery Systems
MH  - *Biological Products
MH  - Nanotechnology
MH  - *Nanoparticles
MH  - Nanomedicine
OTO - NOTNLM
OT  - Biomedical applications
OT  - Herb
OT  - Nanomaterials
OT  - Natural products
OT  - Toxicity
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/03/10 06:00
MHDA- 2023/04/11 06:42
CRDT- 2023/03/09 18:16
PHST- 2023/01/06 00:00 [received]
PHST- 2023/02/08 00:00 [revised]
PHST- 2023/02/21 00:00 [accepted]
PHST- 2023/04/11 06:42 [medline]
PHST- 2023/03/10 06:00 [pubmed]
PHST- 2023/03/09 18:16 [entrez]
AID - S0927-7765(23)00092-9 [pii]
AID - 10.1016/j.colsurfb.2023.113214 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2023 May;225:113214. doi: 
      10.1016/j.colsurfb.2023.113214. Epub 2023 Feb 24.