PMID- 36893819
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231024
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 117
IP  - 1
DP  - 2023 Sep 1
TI  - Ultrahypofractionated Low-Dose Total Skin Electron Beam in Advanced-Stage Mycosis 
      Fungoides and Sezary Syndrome.
PG  - 164-170
LID - S0360-3016(23)00215-8 [pii]
LID - 10.1016/j.ijrobp.2023.02.052 [doi]
AB  - PURPOSE: The aim of this study was to assess the safety and efficacy of an 
      ultrahypofractionated low-dose total skin electron beam therapy (TSEBT) regimen 
      in patients with advanced mycosis fungoides (MF) or Sezary syndrome (SS). METHODS 
      AND MATERIALS: In this multicenter observational study from 5 German centers, 18 
      total patients with MF or SS underwent TSEBT with a total dose of 8 Gy in 2 
      fractions. The primary endpoint was the overall response rate. RESULTS: Fifteen 
      of 18 patients with stage IIB-IV MF or SS were heavily pretreated with a median 
      of 4 prior systemic therapies. The overall response rate was 88.9% (95% 
      confidence interval [CI], 65.3-98.6), with 3 complete responses (16.9%; 95% CI, 
      3.6-41.4). At a median follow-up period of 13 months, the median time to next 
      treatment (TTNT) was 12 months (95% CI, 8.2-15.8), and the median 
      progression-free survival was 8 months (95% CI, 2-14). A significant reduction in 
      the modified severity-weighted assessment tool, total Skindex-29 score 
      (Bonferroni-corrected P < .005), and all subdomains (Bonferroni-corrected P < 
      .05) was observed after TSEBT. Half of the irradiated patients (n = 9) developed 
      grade 2 acute and subacute toxicities. One patient had confirmed grade 3 acute 
      toxicity. Chronic grade 1 toxicity has been observed in 33% of patients. Patients 
      with erythroderma/SS or prior radiation therapy appear at higher risk of skin 
      toxicities. CONCLUSIONS: TSEBT with 8 Gy in 2 fractions achieves good disease 
      control and symptom palliation with acceptable toxicity, greater convenience, and 
      fewer hospital visits.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Elsayad, Khaled
AU  - Elsayad K
AD  - Department of Radiation Oncology, University Hospital of Muenster, Muenster, 
      Germany. Electronic address: khaled.elsayad@uni-muenster.de.
FAU - Weishaupt, Carsten
AU  - Weishaupt C
AD  - Department of Dermatology, University Hospital of Muenster, Munster, Germany.
FAU - Moustakis, Christos
AU  - Moustakis C
AD  - Department of Radiation Oncology, University Hospital of Muenster, Muenster, 
      Germany.
FAU - Danzer, Moritz Fabian
AU  - Danzer MF
AD  - Institute of Biostatistics and Clinical Research, University of Muenster, 
      Muenster, Germany.
FAU - Muller, Elisa Christina
AU  - Muller EC
AD  - Department of Radiation Oncology, University Hospital of Muenster, Muenster, 
      Germany.
FAU - Rolf, Daniel
AU  - Rolf D
AD  - Department of Radiation Oncology, University Hospital of Muenster, Muenster, 
      Germany.
FAU - Stranzenbach, Rene
AU  - Stranzenbach R
AD  - Department of Dermatology, University Hospital of Bochum, Bochum, Germany.
FAU - Livingstone, Elisabeth
AU  - Livingstone E
AD  - Department of Dermatology, University Hospital of Essen, Essen, Germany.
FAU - Booken, Nina
AU  - Booken N
AD  - Department of Dermatology and Venereology, University Hospital Hamburg-Eppendorf, 
      Hamburg, Germany.
FAU - Stadler, Rudolf
AU  - Stadler R
AD  - Department of Dermatology, Johannes Wesling Medical Centre, University of Bochum, 
      Minden, German.
FAU - Eich, Hans Theodor
AU  - Eich HT
AD  - Department of Radiation Oncology, University Hospital of Muenster, Muenster, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20230308
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Humans
MH  - *Sezary Syndrome/radiotherapy
MH  - *Skin Neoplasms/radiotherapy
MH  - Electrons
MH  - *Mycosis Fungoides/radiotherapy
MH  - Skin
EDAT- 2023/03/10 06:00
MHDA- 2023/10/23 12:44
CRDT- 2023/03/09 19:29
PHST- 2022/09/22 00:00 [received]
PHST- 2023/02/20 00:00 [revised]
PHST- 2023/02/25 00:00 [accepted]
PHST- 2023/10/23 12:44 [medline]
PHST- 2023/03/10 06:00 [pubmed]
PHST- 2023/03/09 19:29 [entrez]
AID - S0360-3016(23)00215-8 [pii]
AID - 10.1016/j.ijrobp.2023.02.052 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2023 Sep 1;117(1):164-170. doi: 
      10.1016/j.ijrobp.2023.02.052. Epub 2023 Mar 8.