PMID- 36894020
OWN - NLM
STAT- MEDLINE
DCOM- 20230327
LR  - 20230412
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 802
DP  - 2023 Apr 1
TI  - Neuronal glutamate transporters are associated with cognitive impairment in 
      obstructive sleep apnea patients without dementia.
PG  - 137168
LID - S0304-3940(23)00125-8 [pii]
LID - 10.1016/j.neulet.2023.137168 [doi]
AB  - Increasing evidence supports a link between obstructive sleep apnea (OSA) and 
      cognition, and the mechanism is complex and still not well understood. We 
      analyzed the relationship between the glutamate transporters and cognitive 
      impairment in OSA. For this study 317 subjects without dementia, including 64 
      healthy controls (HCs), 140 OSA patients with mild cognitive impairment (MCI) and 
      113 OSA patients without cognitive impairment were assessed. All participants who 
      completed polysomnography, cognition and white matter hyperintensity (WMH) volume 
      were used. Plasma neuron-derived exosomes (NDEs) excitatory amino acid 
      transporter 2 (EAAT2) and vesicular glutamate transporter 1 (VGLUT1) proteins 
      were measured by ELISA kits. After 1 year of continuous positive airway pressure 
      (CPAP) treatment, we analyzed plasma NDEs EAAT2 level and cognition changes. 
      Plasma NDEs EAAT2 level was significantly higher in OSA patients than in HCs. 
      Higher plasma NDEs EAAT2 level were significantly associated with cognitive 
      impairment than normal cognition in OSA patients. Plasma NDEs EAAT2 level was 
      inversely associated with the total Montreal Cognitive Assessment (MoCA) scores, 
      visuo-executive function, naming, attention, language, abstraction, delayed 
      recall and orientation. One year after CPAP treatment, plasma NDEs EAAT2 level 
      (P = 0.019) was significantly lower, while MoCA scores (P = 0.013) were 
      significantly increased compared with baseline. Upregulation of neuronal 
      glutamate transporters at baseline may reflect a self-compensatory mechanism to 
      prevent further neuronal damage, while plasma NDEs EAAT2 level was decreased 
      after one year of CPAP therapy, which may be due to the loss of astrocytes and 
      neurons.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Xue, Song
AU  - Xue S
AD  - Weifang Medical University, Weifang, Shandong, China; Department of Neurology, 
      Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, 
      Weihai, Shandong, China.
FAU - Shen, Tengqun
AU  - Shen T
AD  - Department of Neurology, Weihai Municipal Hospital, Cheeloo College of Medicine, 
      Shandong University, Weihai, Shandong, China.
FAU - Li, Mengfan
AU  - Li M
AD  - Department of Neurology, Weihai Municipal Hospital, Cheeloo College of Medicine, 
      Shandong University, Weihai, Shandong, China.
FAU - Leng, Bing
AU  - Leng B
AD  - Department of Neurology, Weihai Municipal Hospital, Cheeloo College of Medicine, 
      Shandong University, Weihai, Shandong, China.
FAU - Yao, Ran
AU  - Yao R
AD  - Department of Neurology, Weihai Municipal Hospital, Cheeloo College of Medicine, 
      Shandong University, Weihai, Shandong, China.
FAU - Gao, Yanling
AU  - Gao Y
AD  - Department of Neurology, Weihai Municipal Hospital, Cheeloo College of Medicine, 
      Shandong University, Weihai, Shandong, China.
FAU - Sun, Hairong
AU  - Sun H
AD  - Department of Neurology, Weihai Municipal Hospital, Cheeloo College of Medicine, 
      Shandong University, Weihai, Shandong, China.
FAU - Li, Zhenguang
AU  - Li Z
AD  - Department of Neurology, Weihai Municipal Hospital, Cheeloo College of Medicine, 
      Shandong University, Weihai, Shandong, China.
FAU - Zhang, Jinbiao
AU  - Zhang J
AD  - Department of Neurology, Weihai Municipal Hospital, Cheeloo College of Medicine, 
      Shandong University, Weihai, Shandong, China. Electronic address: 
      drzhangjinbiao@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230307
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Glutamates)
SB  - IM
MH  - Humans
MH  - *Cognitive Dysfunction
MH  - *Sleep Apnea, Obstructive/complications/therapy
MH  - Cognition/physiology
MH  - Neurons
MH  - Glutamates
MH  - *Dementia/complications
OTO - NOTNLM
OT  - Cognition impairment
OT  - Glutamate transporters
OT  - Neuronal exosomes
OT  - Obstructive sleep apnea
OT  - Oxidative stress
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/03/10 06:00
MHDA- 2023/03/28 06:00
CRDT- 2023/03/09 19:34
PHST- 2022/12/08 00:00 [received]
PHST- 2023/01/30 00:00 [revised]
PHST- 2023/03/05 00:00 [accepted]
PHST- 2023/03/10 06:00 [pubmed]
PHST- 2023/03/28 06:00 [medline]
PHST- 2023/03/09 19:34 [entrez]
AID - S0304-3940(23)00125-8 [pii]
AID - 10.1016/j.neulet.2023.137168 [doi]
PST - ppublish
SO  - Neurosci Lett. 2023 Apr 1;802:137168. doi: 10.1016/j.neulet.2023.137168. Epub 
      2023 Mar 7.