PMID- 36894807
OWN - NLM
STAT- MEDLINE
DCOM- 20230313
LR  - 20230318
IS  - 1432-0991 (Electronic)
IS  - 0343-8651 (Linking)
VI  - 80
IP  - 4
DP  - 2023 Mar 9
TI  - Changes in the Microbiota and their Roles in Patients with Type 2 Diabetes 
      Mellitus.
PG  - 132
LID - 10.1007/s00284-023-03219-x [doi]
AB  - An association between type 2 diabetes mellitus (T2DM) and gut microbiota is well 
      established, but the results of related studies are inconsistent. The purpose of 
      this investigation is to elucidate the characteristics of the gut microbiota in 
      T2DM and non-diabetic subjects. Forty-five subjects were recruited for this 
      study, including 29 T2DM patients and 16 non-diabetic subjects. Biochemical 
      parameters, including body mass index (BMI), fasting plasma glucose (FPG), serum 
      total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and 
      hemoglobin A1c (HbA1c), were analyzed and correlated with the gut microbiota. 
      Bacterial community composition and diversity were detected in fecal samples 
      using direct smear, sequencing, and real-time polymerase chain reaction (PCR). In 
      this study, it was observed that indicators such as BMI, FPG, HbA1c, TC, and TG 
      in T2DM patients were on the rise, concurrent with dysbiosis of the microbiota. 
      We observed an increase in Enterococci and a decrease in Bacteroides, 
      Bifidobacteria, and Lactobacilli in patients with T2DM. Meanwhile, total 
      short-chain fatty acids (SCFAs) and D-lactate concentrations were decreased in 
      the T2DM group. In addition, FPG was positively correlated with Enterococcus and 
      negatively correlated with Bifidobacteria, Bacteroides, and Lactobacilli. This 
      study reveals that microbiota dysbiosis is associated with disease severity in 
      patients with T2DM. The limitation of this study is that only common bacteria 
      were noted in this study, and more in-depth related studies are urgently needed.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - He, Qiao-Ling
AU  - He QL
AD  - Department of Clinical Laboratory, Huaihe Hospital of Henan University, 115 Ximen 
      Street, Kaifeng, Henan, China.
FAU - Wang, Hui-Chao
AU  - Wang HC
AD  - Department of Nephrology, First Affiliated Hospital of Henan University, Kaifeng, 
      China.
FAU - Ma, Yu-Ke
AU  - Ma YK
AD  - Department of Clinical Laboratory, Huaihe Hospital of Henan University, 115 Ximen 
      Street, Kaifeng, Henan, China.
FAU - Yang, Rui-Lin
AU  - Yang RL
AD  - Department of Clinical Laboratory, Huaihe Hospital of Henan University, 115 Ximen 
      Street, Kaifeng, Henan, China.
FAU - Dai, Zhi-Feng
AU  - Dai ZF
AD  - Department of Clinical Laboratory, Huaihe Hospital of Henan University, 115 Ximen 
      Street, Kaifeng, Henan, China.
FAU - Yang, Jing-Nan
AU  - Yang JN
AD  - Department of Clinical Laboratory, Huaihe Hospital of Henan University, 115 Ximen 
      Street, Kaifeng, Henan, China.
FAU - Xu, Yao
AU  - Xu Y
AD  - Department of Clinical Laboratory, Huaihe Hospital of Henan University, 115 Ximen 
      Street, Kaifeng, Henan, China.
FAU - Wei, Dan-Dan
AU  - Wei DD
AD  - Department of Clinical Laboratory, Huaihe Hospital of Henan University, 115 Ximen 
      Street, Kaifeng, Henan, China.
FAU - Zhu, Li-Ping
AU  - Zhu LP
AD  - Department of Endocrinology, Huaihe Hospital of Henan University, Kaifeng, China.
FAU - Lin, Xu-Hong
AU  - Lin XH
AD  - Department of Clinical Laboratory, Huaihe Hospital of Henan University, 115 Ximen 
      Street, Kaifeng, Henan, China. 10220017@vip.henu.edu.cn.
LA  - eng
GR  - 81500430/National Natural Science Foundation of China/
GR  - U1304802/National Natural Science Foundation of China/
GR  - 17A320019/Key Scientific Research Projects of Higher Education in Henan/
GR  - 182102310544/the Henan Science and Technology Planning Project/
GR  - 192102310045/the Henan Science and Technology Planning Project/
PT  - Journal Article
DEP - 20230309
PL  - United States
TA  - Curr Microbiol
JT  - Current microbiology
JID - 7808448
RN  - 0 (Glycated Hemoglobin)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2
MH  - Glycated Hemoglobin
MH  - *Insulin Resistance
MH  - Dysbiosis/complications
MH  - *Microbiota
EDAT- 2023/03/10 06:00
MHDA- 2023/03/14 06:00
CRDT- 2023/03/09 23:29
PHST- 2022/03/10 00:00 [received]
PHST- 2023/02/10 00:00 [accepted]
PHST- 2023/03/09 23:29 [entrez]
PHST- 2023/03/10 06:00 [pubmed]
PHST- 2023/03/14 06:00 [medline]
AID - 10.1007/s00284-023-03219-x [pii]
AID - 10.1007/s00284-023-03219-x [doi]
PST - epublish
SO  - Curr Microbiol. 2023 Mar 9;80(4):132. doi: 10.1007/s00284-023-03219-x.