PMID- 36894956
OWN - NLM
STAT- MEDLINE
DCOM- 20230313
LR  - 20231102
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Mar 9
TI  - Prevalence of anemia and its associated factors among patients with type 2 
      diabetes mellitus in a referral diabetic clinic in the north of Iran.
PG  - 58
LID - 10.1186/s12902-023-01306-5 [doi]
LID - 58
AB  - BACKGROUND: PURPOSE: This study intended to investigate the prevalence of anemia 
      and its associated factors among patients with type 2 diabetes mellitus (T2DM) in 
      Gorgan, Iran. METHODS: This cross-sectional study was conducted on 415 (109 men) 
      patients with T2DM referred to the referral diabetes clinic of Sayad Shirazi 
      Hospital in Gorgan in 2021. Demographic information, anthropometric indices, past 
      medical history,  and some laboratory data on cell counts, serum blood 
      glucose, HbA1c, creatinine, lipid/iron profiles, and urinary albumin were 
      collected. The univariable and multivariable logistic regression analysis was 
      applied to compute odds ratios (ORs) and 95% confidence intervals (CI) for 
      potential associated factors, using SPSS version 21. The multivariable Model was 
      adjusted for obesity, Hb A1c, T2DM duration, using glucose-lowering drugs (GLDs), 
      chronic kidney disease (CKD), albuminuria, hypertriglyceridemia, and 
      hypercholesterolemia.  RESULTS: The prevalence of anemia was 21.5% [95%CI: 
      17.6-25.7] among our total participants. The corresponding values for men and 
      women were 20.2 (13.1-29.0) and 21.9 (17.4-27.0), respectively.The adjusted model 
      revealed that obesity (OR, 1.94 [95% CI, 1.17-3.23]), T2DM duration for more than 
      five years (OR, 3.12 [1.78-5.47]), albuminuria (OR, 6.37 [3.13-10.91]), chronic 
      kidney disease (OR, 4.30 [ 2.83-7.29]) and hypertriglyceridemia (OR, 1.72 [ 
      1.21-2.77]) were significantly associated with prevalent anemia among patients 
      with T2DM. Moreover, using insulin separately or in combination with oral GLDs 
      associated positively with the prevalence of anemia with ORs of 2.60 [1.42-6.42] 
      and 1.87 [1.30-4.37] , respectively. CONCLUSION: Anemia had a high prevalence 
      among patients with T2DM in the north of Iran (about 22%), which is associated 
      with obesity, hypertriglyceridemia, duration of T2DM, and diabetic kidney 
      disease.
CI  - (c) 2023. The Author(s).
FAU - Hizomi Arani, Reyhane
AU  - Hizomi Arani R
AD  - Prevention of Metabolic Disorders Research Center, Research Institute for 
      Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Fakhri, Farima
AU  - Fakhri F
AD  - Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, 
      Kerman University of Medical Science, 7616913555, Kerman, Iran.
FAU - Naeimi Tabiee, Mohammad
AU  - Naeimi Tabiee M
AD  - Department of Internal Medicine, Hematology and Oncology disorders, Clinical 
      Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan University of 
      Medical Sciences, Gorgan, Iran.
FAU - Talebi, Fatemeh
AU  - Talebi F
AD  - Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan 
      University of Medical Sciences, Gorgan, Iran.
FAU - Talebi, Zahra
AU  - Talebi Z
AD  - Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan 
      University of Medical Sciences, Gorgan, Iran.
FAU - Rashidi, Negin
AU  - Rashidi N
AD  - Institute of Medical Science, University of Toronto, Toronto, CA, Canada.
FAU - Zahedi, Maryam
AU  - Zahedi M
AD  - Department of Internal Medicine, Endocrinology and metabolic disorders, Clinical 
      Research Development Unit (CRDU), Sayyad Shirazi Hospital, Golestan University of 
      Medical Sciences, Gorgan, Iran. drmaryam.zahedi@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20230309
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Prevalence
MH  - Cross-Sectional Studies
MH  - Iran/epidemiology
MH  - Albuminuria/etiology/complications
MH  - *Renal Insufficiency, Chronic/epidemiology
MH  - Obesity/complications/epidemiology
MH  - *Anemia/epidemiology/etiology
MH  - *Hypertriglyceridemia/complications
MH  - Risk Factors
PMC - PMC9997001
OTO - NOTNLM
OT  - Anemia
OT  - Iran
OT  - Prevalence
OT  - Type 2 diabetes mellitus
COIS- The Ethics Committee of Golestan University of Medical Sciences approved this 
      study (ethics Code: IR.GOUMS.REC.1398.170). This research complied with the 
      principles of the declaration of Helsinki. All methods were carried out in 
      accordance with relevant guidelines and regulations. Informed consent was 
      obtained from all subjects and/or their legal guardian(s) participating in this 
      study. A copy of the written consent is available for review by the Series Editor 
      of this journal. The authors declare that they have no competing interests. The 
      authors declare that they have no competing interests.
EDAT- 2023/03/10 06:00
MHDA- 2023/03/14 06:00
PMCR- 2023/03/09
CRDT- 2023/03/09 23:37
PHST- 2022/04/02 00:00 [received]
PHST- 2023/02/18 00:00 [accepted]
PHST- 2023/03/09 23:37 [entrez]
PHST- 2023/03/10 06:00 [pubmed]
PHST- 2023/03/14 06:00 [medline]
PHST- 2023/03/09 00:00 [pmc-release]
AID - 10.1186/s12902-023-01306-5 [pii]
AID - 1306 [pii]
AID - 10.1186/s12902-023-01306-5 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2023 Mar 9;23(1):58. doi: 10.1186/s12902-023-01306-5.