PMID- 36896214
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230311
IS  - 2452-1094 (Print)
IS  - 2452-1094 (Electronic)
IS  - 2452-1094 (Linking)
VI  - 8
IP  - 3
DP  - 2023 May-Jun
TI  - Radiation Therapy in the German Hodgkin Study Group HD 16 and HD 17 Trials: 
      Quality Assurance and Dosimetric Analysis for Hodgkin Lymphoma in the Modern Era.
PG  - 101169
LID - 10.1016/j.adro.2022.101169 [doi]
LID - 101169
AB  - PURPOSE: Radiation therapy (RT) is an integral part of treatment concepts for 
      early-stage Hodgkin lymphoma. This analysis reports on RT quality in the recent 
      HD16 and 17 trials of the German Hodgkin Study Group (GHSG). METHODS AND 
      MATERIALS: All RT plans of involved-node radiation therapy (INRT) in HD 17 were 
      requested for analysis, along with 100 and 50 involved-field radiation therapy 
      (IFRT) plans in HD 16 and 17, respectively. A structured assessment regarding 
      field design and protocol adherence was performed by the reference radiation 
      oncology panel of the GHSG. RESULTS: Overall, 100 (HD 16) and 176 (HD 17) 
      patients were eligible for analysis. In HD 16, 84% of RT series were evaluated as 
      correct, with significant improvement compared with the predecessor studies (P < 
      .001). In HD 17, 76.1% of INRT cases revealed a correct RT design compared with 
      69.0% of IFRT-cases, which was superior to previous studies (P < .001). Comparing 
      INRT and IFRT, we found no significant differences in the percentage of any 
      deviation (P = .418) or major deviations (P = .466). Regarding dosimetry, INRT 
      was accompanied by an improvement in thyroid doses. Comparing different RT 
      techniques, we found that intensity-modulated RT showed a reduction of high doses 
      in the lung at the expense of an increased low-dose exposure in HD 17. 
      CONCLUSIONS: The latest study generation of the GHSG demonstrates an improved 
      quality in RT. A modern INRT design could be established without deterioration in 
      quality. On a conceptual level, an individual consideration of the appropriate RT 
      technique has to be performed.
CI  - (c) 2022 The Author(s).
FAU - Oertel, Michael
AU  - Oertel M
AD  - Department of Radiation Oncology, University Hospital Muenster, Muenster, 
      Germany.
FAU - Hering, Dominik
AU  - Hering D
AD  - Department of Radiation Oncology, University Hospital Muenster, Muenster, 
      Germany.
FAU - Nacke, Nina
AU  - Nacke N
AD  - Department of Radiation Oncology, University Hospital Muenster, Muenster, 
      Germany.
FAU - Kittel, Christopher
AU  - Kittel C
AD  - Department of Radiation Oncology, University Hospital Muenster, Muenster, 
      Germany.
FAU - Kroger, Kai
AU  - Kroger K
AD  - Department of Radiation Oncology, University Hospital Muenster, Muenster, 
      Germany.
FAU - Kriz, Jan
AU  - Kriz J
AD  - Department of Radiation Oncology, Alexianer Clemenshospital Muenster, Muenster, 
      Germany.
FAU - Fuchs, Michael
AU  - Fuchs M
AD  - Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn 
      Cologne, Dusseldorf, University Hospital of Cologne, Cologne, Germany.
FAU - Baues, Christian
AU  - Baues C
AD  - Department of Radiation Oncology and Cyberknife Center, University Hospital of 
      Cologne, Cologne, Germany.
FAU - Vordermark, Dirk
AU  - Vordermark D
AD  - Department of Radiation Oncology, University Hospital Halle (Saale), Halle 
      (Saale), Germany.
FAU - Engenhart-Cabillic, Rita
AU  - Engenhart-Cabillic R
AD  - Department of Radiotherapy and Radiation Oncology, University Hospital 
      Giessen-Marburg, Marburg, Germany.
FAU - Herfarth, Klaus
AU  - Herfarth K
AD  - Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, 
      Germany.
FAU - Lukas, Peter
AU  - Lukas P
AD  - Department of Radiooncology, Medical University Innsbruck, Innsbruck, Austria.
FAU - Schmidberger, Heinz
AU  - Schmidberger H
AD  - Department of Radiotherapy and Radiation Oncology, University Hospital Mainz, 
      Mainz, Germany.
FAU - Marnitz, Simone
AU  - Marnitz S
AD  - Department of Radiation Oncology and Cyberknife Center, University Hospital of 
      Cologne, Cologne, Germany.
FAU - Borchmann, Peter
AU  - Borchmann P
AD  - Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn 
      Cologne, Dusseldorf, University Hospital of Cologne, Cologne, Germany.
FAU - Engert, Andreas
AU  - Engert A
AD  - Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn 
      Cologne, Dusseldorf, University Hospital of Cologne, Cologne, Germany.
FAU - Haverkamp, Uwe
AU  - Haverkamp U
AD  - Department of Radiation Oncology, University Hospital Muenster, Muenster, 
      Germany.
FAU - Eich, Hans Theodor
AU  - Eich HT
AD  - Department of Radiation Oncology, University Hospital Muenster, Muenster, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20221230
PL  - United States
TA  - Adv Radiat Oncol
JT  - Advances in radiation oncology
JID - 101677247
PMC - PMC9991533
EDAT- 2023/03/11 06:00
MHDA- 2023/03/11 06:01
PMCR- 2022/12/30
CRDT- 2023/03/10 02:39
PHST- 2022/12/21 00:00 [received]
PHST- 2022/12/23 00:00 [accepted]
PHST- 2023/03/10 02:39 [entrez]
PHST- 2023/03/11 06:00 [pubmed]
PHST- 2023/03/11 06:01 [medline]
PHST- 2022/12/30 00:00 [pmc-release]
AID - S2452-1094(22)00274-3 [pii]
AID - 101169 [pii]
AID - 10.1016/j.adro.2022.101169 [doi]
PST - epublish
SO  - Adv Radiat Oncol. 2022 Dec 30;8(3):101169. doi: 10.1016/j.adro.2022.101169. 
      eCollection 2023 May-Jun.