PMID- 36897548
OWN - NLM
STAT- MEDLINE
DCOM- 20230419
LR  - 20230421
IS  - 1749-0774 (Electronic)
IS  - 0914-7470 (Print)
IS  - 0914-7470 (Linking)
VI  - 36
IP  - 3
DP  - 2023 May
TI  - Prognostic and functional roles of EIF4G1 in lung squamous cell carcinoma.
PG  - 1099-1107
LID - 10.1007/s13577-023-00884-9 [doi]
AB  - Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) is highly expressed 
      in many cancers and affects their occurrence and development. However, the effect 
      of EIF4G1 on the prognosis, biological function and the relevant mechanism in 
      lung squamous cell carcinoma (LSCC) is unclear. Through clinical cases, Cox's 
      proportional hazard model and Kaplan-Meier plotter survival analysis, we find the 
      expression levels of EIF4G1 are dependent on age and clinical stage, high 
      expression of EIF4G1 could be used to predict the overall survival of LSCC 
      patients. LSCC cell line NCI-H1703, NCI-H226 and SK-MES-1infected with EIF4G1 
      siRNA are used to detect the function of EIF4G1 with cell proliferation and 
      tumorigenesis in vivo and vitro. The data show that EIF4G1 promotes tumor cell 
      proliferation and the G1/S transition of cell cycle in LSCC, then the biological 
      function of LSCC is effected by the AKT/mTOR pathway. Above all, these results 
      have demonstrated that EIF4G1 promotes LSCC cell proliferation and may represent 
      an indicator of prognosis in LSCC.
CI  - (c) 2023. The Author(s).
FAU - Bai, Baoxin
AU  - Bai B
AUID- ORCID: 0000-0003-3766-3628
AD  - Research Center for Translational Medicine, Shanghai East Hospital, Tongji 
      University School of Medicine, Shanghai, 200092, China.
AD  - Research Center for Translational Medicine, Shanghai East Hospital, GuiLin 
      University School of Medicine, Guilin, 541004, China.
AD  - Hubei University of Medicine, No. 30, Renmin South Road, Maojian District, 
      Shiyan, 442000, China.
FAU - Dong, Lin
AU  - Dong L
AD  - Research Center for Translational Medicine, Shanghai East Hospital, Tongji 
      University School of Medicine, Shanghai, 200092, China.
AD  - Department of Cardiothoracic Surgery, Shanghai East Hospital, Tongji University 
      School of Medicine, Shanghai, 200120, China.
FAU - Feng, Minghao
AU  - Feng M
AD  - Research Center for Translational Medicine, Shanghai East Hospital, Tongji 
      University School of Medicine, Shanghai, 200092, China.
AD  - Department of Cardiothoracic Surgery, Shanghai East Hospital, Tongji University 
      School of Medicine, Shanghai, 200120, China.
FAU - Zhang, Zhiwen
AU  - Zhang Z
AD  - Research Center for Translational Medicine, Shanghai East Hospital, Tongji 
      University School of Medicine, Shanghai, 200092, China.
FAU - Lu, Ying
AU  - Lu Y
AD  - Research Center for Translational Medicine, Shanghai East Hospital, Tongji 
      University School of Medicine, Shanghai, 200092, China.
FAU - Xu, Zengguang
AU  - Xu Z
AUID- ORCID: 0000-0002-4814-9635
AD  - Research Center for Translational Medicine, Shanghai East Hospital, Tongji 
      University School of Medicine, Shanghai, 200092, China. xuzg1998@tongji.edu.cn.
AD  - Research Center for Translational Medicine, Shanghai East Hospital, GuiLin 
      University School of Medicine, Guilin, 541004, China. xuzg1998@tongji.edu.cn.
FAU - Liu, Yali
AU  - Liu Y
AD  - Research Center for Translational Medicine, Shanghai East Hospital, Tongji 
      University School of Medicine, Shanghai, 200092, China. yaliliuliu@163.com.
LA  - eng
GR  - 81972183/National Natural Science Foundation of China/
GR  - 21Y05/Shiyan Science and technology/
PT  - Journal Article
DEP - 20230310
PL  - Japan
TA  - Hum Cell
JT  - Human cell
JID - 8912329
RN  - 0 (EIF4G1 protein, human)
RN  - 0 (Eukaryotic Initiation Factor-4G)
SB  - IM
MH  - Humans
MH  - Prognosis
MH  - *Carcinoma, Non-Small-Cell Lung/genetics
MH  - *Carcinoma, Squamous Cell/pathology
MH  - Cell Proliferation/genetics
MH  - *Lung Neoplasms/pathology
MH  - Lung/metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - Cell Line, Tumor
MH  - Eukaryotic Initiation Factor-4G/genetics/metabolism
PMC - PMC10110680
OTO - NOTNLM
OT  - EIF4G1
OT  - Functional role
OT  - LSCC
OT  - Prognosis
COIS- The authors confirm that they have no conflicts of interest in this work.
EDAT- 2023/03/11 06:00
MHDA- 2023/04/19 06:42
PMCR- 2023/03/10
CRDT- 2023/03/10 11:24
PHST- 2021/09/29 00:00 [received]
PHST- 2023/02/17 00:00 [accepted]
PHST- 2023/04/19 06:42 [medline]
PHST- 2023/03/11 06:00 [pubmed]
PHST- 2023/03/10 11:24 [entrez]
PHST- 2023/03/10 00:00 [pmc-release]
AID - 10.1007/s13577-023-00884-9 [pii]
AID - 884 [pii]
AID - 10.1007/s13577-023-00884-9 [doi]
PST - ppublish
SO  - Hum Cell. 2023 May;36(3):1099-1107. doi: 10.1007/s13577-023-00884-9. Epub 2023 
      Mar 10.