PMID- 36898710
OWN - NLM
STAT- MEDLINE
DCOM- 20230314
LR  - 20230314
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 16
IP  - 3
DP  - 2023 Mar 10
TI  - Radiographic evolution of myelitis in a case of glial fibrillary acidic protein 
      (GFAP) astrocytopathy.
LID - 10.1136/bcr-2022-248921 [doi]
LID - e248921
AB  - Autoimmune glial fibrillar acidic protein (GFAP) astrocytopathy is a rare 
      autoimmune neuroinflammatory disorder that affects the central nervous system. We 
      present a case of GFAP astrocytopathy in a middle-aged male who presented with 
      constitutional symptoms, encephalopathy and lower extremity weakness and 
      numbness. Initially MRI of the spine was normal, but he subsequently developed 
      longitudinally extensive myelitis and meningoencephalitis. Workup for infectious 
      aetiologies was negative and the patient's clinical course worsened despite broad 
      antimicrobial coverage. Ultimately, he was found to have anti-GFAP antibodies in 
      his cerebral spinal fluid consistent with GFAP astrocytopathy. He was treated 
      with steroids and plasmapheresis with clinical and radiographic improvement. This 
      case demonstrates the temporal evolution of myelitis on MRI in a case of 
      steroid-refractory GFAP astrocytopathy.
CI  - (c) BMJ Publishing Group Limited 2023. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Goyne, Christopher E
AU  - Goyne CE
AD  - Neurology, University of California, La Jolla, California, USA 
      cgoyne@health.ucsd.edu.
FAU - Piccioni, David
AU  - Piccioni D
AD  - University of California, La Jolla, California, USA.
FAU - Handwerker, Jason
AU  - Handwerker J
AD  - University of California Medical Center Hillcrest, San Diego, California, USA.
FAU - Rajagopal, Amutha
AU  - Rajagopal A
AD  - Infectious Disease, University of California, La Jolla, California, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20230310
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Middle Aged
MH  - Humans
MH  - Male
MH  - Glial Fibrillary Acidic Protein
MH  - Astrocytes
MH  - *Myelitis
MH  - *Meningoencephalitis
MH  - Brain/metabolism
MH  - Autoantibodies
PMC - PMC10008168
OTO - NOTNLM
OT  - Infection (neurology)
OT  - Neuroimaging
OT  - Neurology
OT  - Radiology
OT  - Spinal cord
COIS- Competing interests: None declared.
EDAT- 2023/03/11 06:00
MHDA- 2023/03/15 06:00
PMCR- 2023/03/10
CRDT- 2023/03/10 20:32
PHST- 2023/03/10 20:32 [entrez]
PHST- 2023/03/11 06:00 [pubmed]
PHST- 2023/03/15 06:00 [medline]
PHST- 2023/03/10 00:00 [pmc-release]
AID - 16/3/e248921 [pii]
AID - bcr-2022-248921 [pii]
AID - 10.1136/bcr-2022-248921 [doi]
PST - epublish
SO  - BMJ Case Rep. 2023 Mar 10;16(3):e248921. doi: 10.1136/bcr-2022-248921.