PMID- 36899306
OWN - NLM
STAT- MEDLINE
DCOM- 20230314
LR  - 20230317
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Mar 11
TI  - Type 2 diabetes mellitus and In-hospital Major Adverse Cardiac and 
      Cerebrovascular Events (MACCEs) and postoperative complications among patients 
      undergoing on-pump isolated coronary artery bypass surgery in Northeastern Iran.
PG  - 130
LID - 10.1186/s12872-023-03163-5 [doi]
LID - 130
AB  - BACKGROUND: Diabetes Mellitus (DM) is a rapidly growing disorder worldwide, 
      especially in the Middle East. A higher incidence of coronary artery diseases 
      requiring coronary artery bypass graft (CABG) surgery has been reported in 
      patients with diabetes. We assessed the association between type 2 diabetes 
      mellitus (T2DM) and in-hospital major adverse cardiac and cerebrovascular events 
      (MACCEs) and postoperative complications among patients who underwent on-pump 
      isolated CABG. METHODS: In this retrospective cohort study, we used the data 
      registered for CABG patients from two heart centers in the Golestan province 
      (North of Iran) between 2007 and 2016. The study population included 1956 
      patients divided into two groups: 1062 non-diabetic patients and 894 patients 
      with diabetes (fasting plasma glucose >/=126 mg/dl or using antidiabetic 
      medications). The study outcome was in-hospital MACCEs, a composite outcome of 
      myocardial infarction (MI), stroke and cardiovascular death, and 
      postoperative complications, including postoperative arrhythmia, acute atrial 
      fibrillation (AF), major bleeding (defined as reoperation due to bleeding), and 
      acute kidney injury (AKI). RESULTS: During the 10-year study period, 1956 adult 
      patients with a mean (SD) age of 59.0 (9.60) years were included. After 
      adjustment for age, gender, ethnicity, obesity, opium consumption, and smoking, 
      diabetes was a predictor of postoperative arrhythmia (AOR 1.30, 95% CI 1.08-1.57; 
      P = 0.006). While it was not a predictor of in-hospital MACCEs (AOR 1.35, 95% CI 
      0.86, 2.11; P = 0.188), AF (AOR 0.85, 95% CI 0.60-1.19; P = 0.340), major 
      bleeding (AOR 0.80, 95% CI 0.50, 1.30; P = 0.636) or AKI (AOR 1.29, 95% CI 0.42, 
      3.96; P 0.656) after CABG surgery. CONCLUSION: Findings indicated that diabetes 
      increased the risk of postoperative arrhythmia by 30%. However, we found similar 
      in-hospital MACCEs, acute AF, major bleeding, and AKI following CABG surgery in 
      both diabetic and non-diabetic patients.
CI  - (c) 2023. The Author(s).
FAU - Nomali, Mahin
AU  - Nomali M
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran.
AD  - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism 
      Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Ayati, Aryan
AU  - Ayati A
AD  - Cardiovascular Diseases Research Institute, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Tayebi, Amirhossein
AU  - Tayebi A
AD  - Clinical Research Development Unit (CRDU), Shahid Rajaei Educational & Medical 
      Center, Alborz University of Medical Sciences, Karaj, Iran.
FAU - Heidari, Mohammad Eghbal
AU  - Heidari ME
AD  - Student Research Center, School of Nursing and Midwifery, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Moghaddam, Keyvan
AU  - Moghaddam K
AD  - Kordkuy Amiralmomenin Hospital, Golestan University of Medical Sciences, Gorgan, 
      Iran.
FAU - Mosallami, Soheil
AU  - Mosallami S
AD  - Kordkuy Amiralmomenin Hospital, Golestan University of Medical Sciences, Gorgan, 
      Iran.
FAU - Riahinokandeh, Gholamali
AU  - Riahinokandeh G
AD  - Department of Surgery, School of Medicine, Sayyad Shirazi Hospital, Kordkuy 
      Amiralmomenin Hospital, Golestan University of Medical Sciences, Gorgan, Iran.
FAU - Nomali, Mahdis
AU  - Nomali M
AD  - Alejalil Hospital, Golestan University of Medical Sciences, Gorgan, Iran.
FAU - Roshandel, Gholamreza
AU  - Roshandel G
AUID- ORCID: 0000-0002-5494-0722
AD  - Golestan Research Center of Gastroenterology and Hepatology, Golestan University 
      of Medical Sciences, Gorgan, Iran. roshandel_md@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230311
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
SB  - IM
MH  - Adult
MH  - Humans
MH  - Middle Aged
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Retrospective Studies
MH  - Iran
MH  - Coronary Artery Bypass/adverse effects
MH  - *Coronary Artery Disease/surgery
MH  - Postoperative Complications/etiology
MH  - *Atrial Fibrillation/epidemiology
MH  - *Acute Kidney Injury/etiology
MH  - Treatment Outcome
PMC - PMC10007752
OTO - NOTNLM
OT  - Complications
OT  - Coronary artery bypass
OT  - Diabetes Mellitus, Type2
OT  - Major adverse cardiovascular events
OT  - Retrospective studies
COIS- All authors declare no competing interests.
EDAT- 2023/03/11 06:00
MHDA- 2023/03/15 06:00
PMCR- 2023/03/11
CRDT- 2023/03/10 23:33
PHST- 2022/11/25 00:00 [received]
PHST- 2023/03/02 00:00 [accepted]
PHST- 2023/03/10 23:33 [entrez]
PHST- 2023/03/11 06:00 [pubmed]
PHST- 2023/03/15 06:00 [medline]
PHST- 2023/03/11 00:00 [pmc-release]
AID - 10.1186/s12872-023-03163-5 [pii]
AID - 3163 [pii]
AID - 10.1186/s12872-023-03163-5 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2023 Mar 11;23(1):130. doi: 10.1186/s12872-023-03163-5.